Ask about this productRelated genes to: ACO2 Blocking Peptide
- Gene:
- ACO2 NIH gene
- Name:
- aconitase 2
- Previous symbol:
- -
- Synonyms:
- ACONM
- Chromosome:
- 22q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-12-01
Related products to: ACO2 Blocking Peptide
Related articles to: ACO2 Blocking Peptide
- The number of patients requiring home mechanical ventilation is rising, while in-person follow-up is increasingly burdensome for patients and health systems. Telehealth may maintain clinical stability and improve care efficiency. This systematic review examined the clinical and economic effectiveness of telehealth in the management of home mechanical ventilation. - Source: PubMed
Publication date: 2026/09/28
Filser Paula JohannaMünchenberg Pauline SarahBerger ElkeBusse ReinhardGarcia CarmenKurth Tobias - Rising atmospheric CO₂ concentrations may alter the protein composition of wheat and thereby affect grain quality. Ten wheat cultivars were treated with elevated CO concentration (eCO, 546 ppm) and compared to ambient CO concentration (aCO, 450 ppm) in the field to assess changes in amylase/trypsin-inhibitors (ATI), puroindolins (PIN), and gluten proteins using targeted LC-MS/MS and stable isotope dilution analysis. ATI content was higher under eCO than under aCO, whereas PIN, gluten proteins, and selected celiac disease-active peptides were lower. The response to eCO was strongly genotype-dependant. The lower gluten protein content under eCO was associated with reduced baking quality. While the observed changes in ATI and selected celiac disease-active peptides may be relevant for wheat-related disorders, their biological and immunological significance remains to be established. The findings highlight the importance of identifying cultivars with low levels of ATI and celiac disease-active peptides while maintaining good baking quality under rising CO. - Source: PubMed
Publication date: 2026/09/20
Geisslitz SabrinaKaemper ChristineNorwig Marie-ChristinFechner AndreasKnopf OliverMuller OnnoGeyer ManuelHartl LorenzScherf Katharina Anne - Global climate warming has led to increasingly frequent and prolonged extreme summer heat events, posing severe environmental challenges to aquaculture systems. Extreme summer heat can disrupt the performance of pond-cultured ectotherms. The Chinese mitten crab (Eriocheir sinensis) is an economically important freshwater crustacean, but coordinated molecular differences following contrasting natural summers remain incompletely characterized. - Source: PubMed
Publication date: 2026/08/26
Liu RongchenZhang XinyueWu PeiyunLi YananHu JinghaoZang YanYao SongLi XuguangChen YuchenLiu LongchengWang RuifangYang YanpingZhang HongleiWang HaoZhou JunXuan Fujun - Clear cell renal cell carcinoma (ccRCC) represents one of the most prevalent malignancies worldwide, characterized by high incidence and mortality rates. It is characterized by mitochondrial dysfunction with enhanced Warburg effect. In this study, we identify the sortilin-related receptor 1 (SORL1) as a regulator of ccRCC progression and a potential molecular target for oxidative phosphorylation inhibition. The present evidence demonstrates that SORL1 promotes the ubiquitin-mediated degradation of C-MYC via TRIM22, which is associated with the downregulation of ACO2 and IDH2 and a consequent suppression of oxidative phosphorylation capacity. Molecular investigations further indicated that Cefoperazone could bind to SORL1 and increase its protein level, exerting the SORL1-triggering function. Targeting delivery Cefoperazone exhibits unexpected anti-tumor performances in ccRCC. Collectively, our findings establish SORL1 as a tumor suppressor in ccRCC and highlight its potential as a therapeutic target in advancing ccRCC clinical treatment strategies. - Source: PubMed
Publication date: 2026/09/04
Wang KeyiSong WeiBai QiShen ShaozeLu XiaoSu ChenxuanYang ShiWang YidiXia YuZan RuiJiang ShuaiGuo Jianming - Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying metabolic signals involved remain unclear. Using a mouse model of mitohormesis, we show that transient mitochondrial superoxide stress during embryogenesis reprograms the adult heart to enhance mitochondrial biogenesis and antioxidant capacity. These adaptations confer protection against mitochondrial and oxidative injury in models of doxorubicin-induced cardiotoxicity, preserving mitochondrial content and preventing cardiac dysfunction and remodeling. Using a cell model of superoxide-mediated mitohormesis, we find that inhibition of mitochondrial aconitase promotes citrate export to the cytosol, where its conversion to acetyl-coenzyme A drives histone acetylation and mitohormetic protection from oxidative stress. Preventing mitochondrial citrate export abolishes these adaptations, while silencing or citrate supplementation recapitulates the response. Together, our findings identify mitochondrial citrate as a redox-sensitive second messenger linking mitochondrial superoxide stress to durable epigenetic and mitohormetic remodeling. - Source: PubMed
Publication date: 2026/09/04
Donnelly Matthew PMangalhara Kailash ChandraLiu YueningLande KathrynRojas Gladys RGrae Kym JReynolds Mack BGhosh SagnikaOlliffe NevaEsparza-Moltó Pau BJohnson Melissa ADufresne SuzanneLouie Allison YMoyzis Alexandra GGuan DeannGustafsson Åsa BG Towers ChristinaKosuri PallavMetallo Christian MHargreaves Diana CShadel Gerald S