Ask about this productRelated genes to: RHBG Blocking Peptide
- Gene:
- RHBG NIH gene
- Name:
- Rh family B glycoprotein (gene/pseudogene)
- Previous symbol:
- -
- Synonyms:
- SLC42A2
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2001-05-08
- Date modifiied:
- 2016-01-13
Related products to: RHBG Blocking Peptide
Related articles to: RHBG Blocking Peptide
- Sex-dependent differences are evident in most organs and contribute to variability in physiological function and disease susceptibility, which can consequently affect therapeutic responses. The kidney is no exception to this finding and recent data suggest that sexual dimorphism exists in the regulation of acid-base homeostasis. - Source: PubMed
Publication date: 2026/07/01
Halter Rebecca ZoeNogueira Coelho JenniferDominguez Rieg Jessica ARieg Timo - : Genetic generalized epilepsies (GGE) often remit in childhood, yet a subset of adults remain pharmacoresistant with substantial morbidity. The genetic basis of adult pharmacoresistant GGE is poorly defined. This descriptive study used whole-genome sequencing (WGS) to identify recurrent coding variants and pathways associated with pharmacoresistant adult GGE. : WGS was performed in ten racially diverse adults (mean age 37.2 years; range 20-52) with electroencephalographically confirmed, pharmacoresistant GGE (mean onset 13.7 years). Analysis prioritized variants present in at least 80% of participants and which were either (i) missense variants predicted deleterious with ANNOVAR or (ii) loss-of-function variants predicted high-impact from snpEff. Pathway enrichment and overlap with a commercial clinical epilepsy gene panel were assessed. : Filtering identified 133 unique, deleterious coding variants across 69 genes shared by at least eight participants. Four genes (APOL4, KMT2C, SON, VDR) overlapped a clinical epilepsy panel, supporting the capacity of WGS to recover clinically relevant loci. Prioritized loci implicated gastrointestinal and metabolic regulators (e.g., MUC6, PNLIPRP2), chemosensory receptors (OR10D3, OR8U1, TAS2R19), neuroimmune mediators (LILRA2, SIGLEC12, OAS2), and ion transporters (KCNJ12, P2RX5, RHBG), consistent with multifactorial mechanisms of pharmacoresistance. : This exploratory WGS study focused exclusively on adults with pharmacoresistant GGE, revealing shared high-impact variants and convergent pathways spanning absorption/metabolism, vitamin D signaling, immunity, and ion transport. Findings broaden the genetic landscape of pharmacoresistant GGE while motivating validation in larger, multiethnic cohorts. - Source: PubMed
Publication date: 2026/05/14
Kidder Benjamin LXu JianGeng RuiDlugas HunterVavilikolanu AnushaChen WeiWasade Vibhangini S - This study evaluated the antibacterial activity and functional effects of yeast polysaccharides derived from three strains (L6, L9, and L10) on growth, immunity, and gut health of red tilapia cultured under seawater conditions. An in vitro antibacterial assay against and was conducted, followed by a 16-week feeding trial using six isonitrogen (crude protein: 370 ± 8 g kg) and iso-energy (gross energy: 11.4 ± 0.2 MJ kg) diets: control, commercial β-glucan, MOS, L6, L9, and L10, each at 1 g/kg. A total of 720 healthy fish (20.06 ± 0.06 g) were randomly assigned to 24 floating cages (1 × 1 × 1 m; four replicates per treatment). Results showed that all YPS exhibited antibacterial activity against ., with L10 showing the strongest inhibition in vitro. Fish fed L10 also exhibited the highest weight gain rate (WG) and lowest feed conversion ratio (FCR) compared with the control group ( < 0.05). Plasma biochemical indices indicated that the L10 group significantly increased total antioxidant capacity, and lysozyme while decreasing malondialdehyde ( < 0.05). Meanwhile, the intestinal anti-inflammatory cytokines were significantly upregulated, and the proinflammatory cytokines were significantly downregulated with the inclusion of yeast polysaccharide derived from the L10 strain ( < 0.05). Furthermore, L10 also improved intestinal morphology and barrier integrity while modulating the microbiota toward beneficial taxa, characterized by increased and reduced . Integrated transcriptomic and metabolomic analyses further revealed activation of immune-, metabolism-, and homeostasis-related genes (e.g., , , and ), alongside the enrichment of amino acids and microbial metabolites (e.g., indole derivatives) associated with mucosal immune regulation. Overall, this study revealed that supplementation of 1 g/kg L10 yeast polysaccharide can promote growth, antioxidant capacity, immune homeostasis, and gut microbiota balance in red tilapia, highlighting the potential as next-generation functional feed additives for sustainable marine aquaculture. - Source: PubMed
Publication date: 2026/05/12
Yuan RuiminWu XiaoyiHe JuyunZhou Zhiyu - This study investigated the role of the Rhesus (Rh) gene family in the adaptation to high alkalinity in Gymnocypris eckloni. We employed bioinformatic analysis of the Rh gene family based on G. eckloni genome data, along with alkalinity stress experiments and gene expression analysis. The results revealed that the Rh gene family in G. eckloni comprises seven members, encoding proteins ranging from 425 to 489 amino acids. Analyses of the motifs, domains, and gene structure all indicated high conservation among family members, albeit with considerable variation in gene structure. Chromosomal localization showed that the Rh genes were distributed across six chromosomes. Predictions of subcellular localization and transmembrane helices confirmed that Rh glycoproteins are transmembrane proteins containing 9-12 transmembrane helices. Under carbonate alkalinity stress, blood ammonia levels in G. eckloni gradually increased and then declined after 48 h of exposure. Gene expression studies demonstrated significant upregulation of Rhag, Rhbg, and Rhcg2a in gill tissue and Rhbg, Rhcg2a, and Rhcg2b in skin tissue after stress exposure. In the kidney, Rhag and Rhcg1 were significantly upregulated, with Rhd exhibiting the highest expression levels. In contrast, liver gene expression was generally low, with only Rhcg2a and Rhcg2b showing significant upregulation after prolonged, high-concentration stress exposure. Western blot analysis of selected Rh proteins (Rhag, Rhbg, Rhcg) in the gill, skin, and kidney revealed that their expression was upregulated following alkalinity stress, largely consistent with the trends observed at the transcript level. This further elucidated the tissue-specific roles of Rh gene family members in ammonia transport: in gill tissue, Rhag, Rhbg, Rhcg1, and Rhcg2a coordinately participate in the ammonia excretion process; in skin tissue, ammonia excretion is primarily mediated by Rhbg, Rhcg2a, and Rhcg2b; in kidney tissue, Rhcg1 plays a key role, and this process may be independent of Rhbg. In contrast, the liver plays a relatively limited role in ammonia excretion. Based on gene expression data, Rhd appears unrelated to ammonia excretion. Although the expression trends of Rh50 (transcript level) paralleled those of Rhag across tissues, its specific function requires further investigation.. This study reveals the expression patterns and suggests potential roles of Rh gene family members in ammonia transport in G. eckloni, providing a preliminary scientific basis for further functional studies and the conservation of this species. - Source: PubMed
Publication date: 2026/04/27
Guo ShouquanLiu DanZhang CunfangNie MiaomiaoYao ZhanwenLi YingTian FeiQi DelinXia Mingzhe - Chronic kidney disease (CKD) imposes a substantial health burden globally, with emerging evidence pointing to the significance of metabolic acidosis and low urinary NH excretion resulting in poor CKD outcomes. The present study aims to identify in CKD patients, loss of function mutations in RhBG, one of the NH/NH transporters in the collecting duct, and to show that NH/NH transport is impaired by these mutations. Single nucleotide polymorphisms of RhBG associated with CKD occurrence were identified using ancestry-stratified data from the Chronic Renal Insufficiency Cohort (CRIC) study. Functional analysis of NH/NH transport was conducted in Xenopus oocytes expressing RhBG protein or mutants. NH and NH transport was evaluated by electrophysiological measurements, including whole cell current, surface pH and intracellular pH. Our study identified six critical RhBG mutations associated with CKD. G86S and G86C inhibited the transport of NH; mutations G148R and G148W completely blocked transport of NH and NH , whereas T250A and T250S only inhibited NH transport. Mutation T250M completely inhibited transport of both NH and NH . Our study identified critical rare non-synonymous single nucleotide polymorphisms in RhBG associated with CKD and elucidated the impact of these variants on NH/NH transport. These data are crucial to our understanding of how mutations can disrupt NH/NH transport, potentially affecting kidney function in CKD patients susceptible to acidosis. KEY POINTS: Acidosis and low urinary ammonium excretion contribute to poor outcomes in chronic kidney disease (CKD). This study investigates how the function of an ammonia transporter in renal collecting duct (RhBG) may contribute to CKD. Here, we report six rare RhBG mutations associated with CKD, identified using data from the Chronic Renal Insufficiency Cohort (CRIC) study. Using electrophysiological measurements, functional analysis in Xenopus oocytes showed that these RhBG mutations disrupt ammonia transport, with some mutations affecting only NH transport, whereas others affect both NH and NH transport. The results suggest that impaired ammonia transport by RhBG contributes to CKD, highlighting the need to understand mechanisms that link function (NH/NH and acid-base regulation) and genetic predisposition to CKD. - Source: PubMed
Publication date: 2026/02/11
Zhou HeAbdulnour-Nakhoul SolangeHamm L LeeNakhoul Nazih L