Ask about this productRelated genes to: TRPV4 Blocking Peptide
- Gene:
- TRPV4 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 4
- Previous symbol:
- -
- Synonyms:
- OTRPC4, TRP12, VROAC, VRL-2, VR-OAC, CMT2C
- Chromosome:
- 12q24.11
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-29
- Date modifiied:
- 2019-04-23
Related products to: TRPV4 Blocking Peptide
Related articles to: TRPV4 Blocking Peptide
- - Source: PubMed
Poole Alastair W - Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with an incompletely understood pathogenesis. Although dysregulation of the enteric nervous system, mucosal barrier, brain-gut axis, and immune-microbiota interactions has been extensively investigated, the contribution of intestinal microcirculatory dysfunction remains largely unclear. In this study, a water avoidance stress (WAS) model was used to induce diarrhea-predominant IBS (IBS-D) in mice, and endothelium-dependent vasorelaxation in mesenteric small resistance arteries was assessed using wire myography. We found that acetylcholine (ACh)-induced endothelium-dependent hyperpolarization (EDH)-mediated vasorelaxation was significantly impaired in WAS-treated mice. This impairment was transient and reversible on days 1 and 3 post-WAS but became sustained by day 10. In contrast, intestinal barrier integrity was preserved on day 1, began to deteriorate by day 3, and was markedly disrupted by day 10, indicating that EDH dysfunction precedes mucosal barrier impairment. Mechanistically, EDH dysfunction was selectively associated with dysregulated store-operated calcium entry (SOCE), whereas ryanodine receptors, inositol 1,4,5-trisphosphate receptors, intermediate- and small-conductance Ca-activated K channels, and TRPV4 channels were not involved. Norepinephrine-induced vasoconstriction was enhanced at day 10, while sodium nitroprusside-induced vasorelaxation remained unaffected. Notably, zinc supplementation restored ACh-induced EDH-mediated vasorelaxation in WAS-treated arteries via Zn signaling and activation of the zinc-sensing receptor (ZnR), suggesting a potential therapeutic strategy. Collectively, these findings demonstrate that SOCE-dependent EDH impairment contributes to intestinal microcirculatory dysfunction, leading to compromised mucosal perfusion and barrier integrity in IBS-D. Targeting Zn/ZnR signaling to restore vascular function may represent a promising therapeutic approach for this disorder. - Source: PubMed
Publication date: 2026/06/18
Zhang LuyunChu FenglanWan HanxingDong Hui - - Source: PubMed
Publication date: 2026/06/11
Luo LanYang XiaofangYi ShuyuanDong ZiyuanWang KanZhu ZichengGao QianGao JianxueJiang YuGong MingZhang HongjiaWang MeiliHei Feilong - Glaucoma leads to progressive degeneration of retinal ganglion cells (RGCs), highlighting an urgent need for neuroprotective strategies beyond intraocular pressure reduction. Our previous work demonstrated that activation of the mechanosensitive channel Transient Receptor Potential Vanilloid 4 (TRPV4) contributes to RGC apoptosis in a chronic ocular hypertension (COH) rat model, and that the TRPV4 antagonist HC-067047 exhibits neuroprotective potential. However, its mechanism of action remains unclear, and its therapeutic efficacy is limited by poor RGC targeting, rapid clearance, and associated toxicity. - Source: PubMed
Publication date: 2026/06/17
Song JiarunZhang XueqiHuang PengweiLi HuiLiu WenhuiWang LiyanWang RuiqingYe ZhuoranZhang JingxinZhang ZhiyueGuo Hui - This study investigated the polyphenolic composition, antioxidant capacity, and antianemic effects of aqueous leaf (JPEL) and berry (JPEB) extracts of Juniperus phoenicea ssp. turbinata L. (J. phoenicea ssp. turbinata). The plant is traditionally used to treat various ailments. HPLC-DAD analysis identified quercetin as the major compound (JPEB 49.09%; JPEL 31.34%), followed by p-coumaric acid (27.07% in JPEB), catechin (14.69% in JPEL), and gallic acid (JPEB 13.69%; JPEL 12.08%). Antioxidant activity was assessed using DPPH and reducing power assays, with the most active extract showing IC = 23.95 ± 0.64 µg/mL and EC = 300 ± 1.41 µg/mL. In vivo, 25 rats were assigned to 5 groups: negative control, PHZ-induced anemic control (40 mg/kg), JPEL-treated, JPEB-treated (300 mg/kg/day for 21 days), and a positive control (ascorbic acid, 10 mg/kg/day). Both extracts significantly ameliorated PHZ-induced hematological disturbances, restoring values toward normal. Molecular docking revealed favorable binding affinities of key phytochemicals with deoxy-hemoglobin and the TRPV4 ankyrin domains, suggesting potential interactions at these targets. However, these in silico findings are predictive and do not confirm functional protection or protein stabilization. The experimental results demonstrated antioxidant activity and improvement of hematological parameters in the animal model. These findings suggest that J. phoenicea ssp. turbinata extracts may warrant further investigation as natural sources of bioactive compounds. Nevertheless, additional pharmacological, toxicological, and clinical studies are required to validate these effects and assess their relevance for therapeutic applications. - Source: PubMed
Chelouati TarikTakie MarouaneEl-Mernissi RafikOukadir ZhorChebaibi Salah-EddineDauelbaitf MusaabBouallegue AmirAlmohammed Omar ABourhia MohammedAli HinaSalamatullah Ahmad MohammadHajji LhoussainBenjelloun Ahmed Samir