Ask about this productRelated genes to: KRT15 Blocking Peptide
- Gene:
- KRT15 NIH gene
- Name:
- keratin 15
- Previous symbol:
- -
- Synonyms:
- K15, CK15, K1CO
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-12
- Date modifiied:
- 2016-03-09
Related products to: KRT15 Blocking Peptide
Related articles to: KRT15 Blocking Peptide
- The hair follicle bulge is regarded as a reservoir of epithelial stem cells for hair regeneration. Hair follicle bulge cells are generally characterized by CD200 expression. However, the relationship between CD200 bulge subpopulations and human hair regenerative capacity remains unknown. In this study, we systematically investigated the CD200- and KRT15-expressing human hair follicle bulge cells by integrating phenotypic characterization, transcriptomic profiling, and hair regeneration assays. CD200 cells from freshly isolated human hair follicle bulge exhibited higher hair-regenerative capability. Using different culture systems, we have observed the correlation between reduced CD200 expression and increased hair regenerative capability of cultured hair follicle bulge cells. Our study refines the functional interpretation of CD200-defined bulge heterogeneity and provides insights for optimizing human bulge cell-based approaches to hair follicle regeneration. - Source: PubMed
Publication date: 2026/04/23
Sun TingHamano SayuriChen JingLing LichenLin JinranYan LeiKageyama TatsutoWu FuyueTan Zheng LinWu WenyuFukuda Junji - Lenvatinib resistance is a major clinical obstacle in the treatment of radioiodine-refractory papillary thyroid cancer (PTC). Clarification of the molecular mechanisms of this resistance is of utmost importance to devise effective therapeutic strategies. We investigated the role of Keratin 15 (KRT15) in lenvatinib resistance through comprehensive in vitro and in vivo studies. Tumor and normal thyroid tissues were analyzed for KRT15 expression and correlation with patient survival. Metabolic profiling was performed to investigate KRT15-dependent alterations in lipid metabolism, namely fatty acid oxidation (FAO). Mechanistic investigations explored the interaction between KRT15, Keratin 81 (KRT81), and Diacylglycerol Kinase B (DGKB). The therapeutic potential of targeting this pathway was evaluated using shRNA-mediated knockdown and pharmacological inhibition. KRT15 overexpression was associated with unfavorable clinical prognosis in thyroid cancer patients. We identified that KRT15 interacts with KRT81 to constitute a regulatory complex, which induces DGKB upregulation. The KRT15-KRT81-DGKB axis controls metabolic reprogramming by upregulating key FAO enzymes (CPT1A and ACOX1), resulting in increased cellular energetics and survival against therapeutic stress. Inhibition of this pathway successfully restored lenvatinib sensitivity in resistant cells. This study illustrates a novel mechanism of cytoskeletal proteins involvement in metabolic adaptation of drug-resistant thyroid cancer cells. The KRT15-KRT81-DGKB pathway is a promising therapeutic target, particularly in combination with lenvatinib, for refractory thyroid cancer patients. - Source: PubMed
Publication date: 2026/04/16
Wang YunjunZhang YuZhao DanWu YiLiao TianWang YuXiang JunChen QiSun Tuanqi - Postoperative recurrence and metastasis in esophageal squamous cell carcinoma (ESCC) are closely associated with cancer stem cells (CSCs), though the heterogeneity and key molecular mechanisms underlying CSC-driven progression remain incompletely understood. In this study, we identified a malignant, stem-like subpopulation in ESCC using single-cell sequencing data and screened for subpopulation-specific markers via machine learning algorithms, identifying KRT15 as a candidate. Functional experiments and demonstrated that the overexpression of KRT15 promoted proliferation, migration, invasion, and stemness in ESCC cells, while its knockdown suppressed these phenotypes. Clinically, high KRT15 expression was significantly associated with poorer overall survival and progression-free survival and served as an independent prognostic risk factor. Collectively, our findings indicate that KRT15 acts as a functional regulator of stemness and invasiveness in ESCC, highlighting its potential as a therapeutic target and a prognostic biomarker for postoperative risk stratification. - Source: PubMed
Publication date: 2026/02/18
Xiong KaiZhu YixuanFang HaoSun XintiLi ZihaoTuerxun DilihumaerZhang Peng - Esophageal squamous cell carcinoma (ESCC) is a highly aggressive disease that carries a poor prognosis and limited therapeutic efficacy, particularly in advanced stages. While immune checkpoint inhibitors (ICIs) have improved outcomes in some patients, resistance mechanisms remain poorly understood. Keratin 15 (KRT15) has been implicated in tumor progression and immune regulation, yet its role in ESCC immunotherapy resistance is unclear. - Source: PubMed
Publication date: 2026/03/10
Yang ChenZhong ZhaoyuLi ChunyangWang HuiChen LujunJiang JingtingWu Changping - Building on the identification of ABCB5 as a marker of limbal stem cells (LSCs), this study examines CD63, a newly identified molecule co-expressed with ABCB5 in limbal epithelial cells, to define its role in maintaining corneal epithelial cell identity. - Source: PubMed
Sasamoto YuzuruSuzuki KoseiSato ShinriLee Catherine A AMartin GabrielleKsander Bruce RFrank Markus HFrank Natasha Y