Ask about this productRelated genes to: EPSTI1 Blocking Peptide
- Gene:
- EPSTI1 NIH gene
- Name:
- epithelial stromal interaction 1
- Previous symbol:
- -
- Synonyms:
- BRESI1, MGC29634
- Chromosome:
- 13q14.11
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-05
- Date modifiied:
- 2016-10-05
Related products to: EPSTI1 Blocking Peptide
Related articles to: EPSTI1 Blocking Peptide
- The dengue virus (DENV) can cause various clinical syndromes and organ damage, known as dengue fever, with the probability of developing severe dengue. However, the underlying mechanisms of host response against DENV infection remain unclear, and there is still no specific medicine for dengue fever. In the present study, we revealed the transcriptomic features of the host factor in patients with DENV infection and explored potential therapeutic medication. - Source: PubMed
Publication date: 2026/04/30
Liu ChengxinYu XinboChen JiafanZhong MingYe BeiWang KaiJiang YongLi GengZhan Shaofeng - Spontaneous ovarian hyperstimulation syndrome (OHSS) is closely associated with follicle stimulating hormone receptor (FSHR) functional mutations. We observed that estrildid finches naturally carry the gain-of-function FSHR p.Thr449Ala mutation found in humans, yet do not develop OHSS, thereby providing a novel and system to study aspects of OHSS prevention. Cross-species single-cell analysis revealed that macrophages, the most abundant immune cells in ovaries, play a pivotal role in OHSS progression. Macrophage depletion exacerbates the manifestations of OHSS in both birds and rats. Pharmacological activation of the G protein-coupled receptor 183 (GPR183) in ovarian macrophages, significantly alleviates OHSS symptoms. Mechanistically, GPR183 activation in macrophages maintains ovarian immune homeostasis by downregulating inflammatory factors (Interleukin 1 alpha: IL1A, Interleukin 6: IL6, Interleukin 1 beta: IL1B) and upregulating immune regulators responsive to external stimuli (sphingomyelin phosphodiesterase acid like 3A: Smpdl3a, Macrophage-expressed gene 1: Mpeg1, Epithelial stromal interaction 1: Epsti1, Unc-93 homolog B1: Unc93b1, Apolipoprotein B mRNA editing enzyme catalytic subunit 1: Apobec1). It markedly altered CD44 molecule (CD44)/Syndecan-4 (SDC4) -mediated intercellular communication between macrophages and endothelial/stromal cells, thereby modulating the ovarian microenvironment. This study identifies ovarian macrophages as a key therapeutic target for OHSS and proposes GPR183 as a novel receptor target for precision macrophage-based interventions. - Source: PubMed
Publication date: 2026/05/05
Yan XiaofeiHuang YongjieYang JiabaoMa SuLiu SongsongHuang XuanBrosius JuergenZheng HuapingYao BingChen LiLai ShanshanDeng Cheng - Sjögren's Syndrome (SS) is a long-term autoimmune disorder marked by damage to exocrine glands and irregularities in the immune system. Currently, there is a significant lack of effective diagnostic biomarkers and targeted therapeutic options for this disorder. This research aimed to identify molecular biomarkers that could be used for SS diagnosis and to explore therapeutic candidates that could address current clinical needs. Multiple public datasets (GSE84844, GSE40611, GSE7451, GSE208260) were retrieved from the Gene Expression Omnibus (GEO) database, including samples of salivary glands, saliva, salivary ducts, and blood from both SS patients and healthy individuals. The GEO2R tool was used to identify Differentially Expressed Genes (DEGs). Five machine learning algorithms-Decision Tree, XGBoost, Random Forest, Lasso Regression, and Gradient Boosting Machines (GBM)-were applied to screen key diagnostic biomarkers. RT-PCR in PBMCs and IHC in salivary gland tissues were used to validate the expression levels of the candidate genes. Furthermore, CIBERSORT was employed to analyze immune cell infiltration in the blood of SS patients. Network pharmacology and molecular docking using CB-Dock2 were performed to explore paeoniflorin's therapeutic potential against SS. Eight common DEGs were identified, among which EPSTI1, IFI44, and IFIT1 were core biomarkers. These genes were significantly upregulated in SS patients (P < 0.05) and exhibited high diagnostic efficacy (AUC: 0.89, 0.90, 0.88, respectively). Blood samples from SS patients showed increased proportions of memory B cells and activated dendritic cells, as well as decreased CD4 naive T cells and γδ T cells (P < 0.05)-changes that correlated with the expression of the three core genes. Paeoniflorin shared 110 common targets with SS (enriched in immune and inflammatory pathways) and bound stably to the three biomarkers (Vina scores: -7.6, -8.7, -7.7). EPSTI1, IFI44, and IFIT1 are promising candidate diagnostic biomarkers for SS, with potential links to immune dysregulation. Paeoniflorin may exert immunomodulatory effects by targeting these genes, but this remains a hypothesis requiring experimental validation. This study provides preliminary insights into SS biomarkers and therapeutic candidates, but prospective clinical validation, functional experiments, and in vivo studies are essential before translation into practice. - Source: PubMed
Publication date: 2026/02/18
Yin YinXu TongtongMa HuijunXia PengchengLuan XiaotianZhang HuiZhu Xiaoming - Osteoporosis is a disease characterized by impaired bone microarchitecture and reduced bone mass. However, its molecular mechanisms are not fully understood. - Source: PubMed
Publication date: 2026/02/10
Zheng ChangjunDing LingzhiXu YanYuan ChiJiang BingjieChen TingtingWang Yongjie - Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis and suboptimal patient management. - Source: PubMed
Publication date: 2026/01/16
Xu HuaLiu YongSong YuyinZheng YifanJing HaifengGao YanfeiZhou DepengChi XiangChen JiaLi Zhengrui