Ask about this productRelated genes to: IL1RL1 Blocking Peptide
- Gene:
- IL1RL1 NIH gene
- Name:
- interleukin 1 receptor like 1
- Previous symbol:
- -
- Synonyms:
- ST2, FIT-1, ST2L, ST2V, DER4, T1, IL33R
- Chromosome:
- 2q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-17
- Date modifiied:
- 2017-07-07
- Gene:
- TMED1 NIH gene
- Name:
- transmembrane p24 trafficking protein 1
- Previous symbol:
- -
- Synonyms:
- ST2L, MGC1270, IL1RL1LG, Il1rl1l, p24gamma1, p24g1
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-07
- Date modifiied:
- 2015-08-11
Related products to: IL1RL1 Blocking Peptide
Related articles to: IL1RL1 Blocking Peptide
- The proinflammatory danger signal IL-33, which is released from damaged or dying cells, achieves its effects via the IL-1R family member ST2L. The detection of IL-33 by ST2L initiates downstream signaling pathways that result in the activation of MAPKs and NF-κB. Here, we show that TMED1 associates with ST2L. Using a series of mutation and deletion constructs, we demonstrate that this interaction is mediated by the GOLD domain of TMED1 and the TIR domain of ST2L. Our findings also demonstrate that TMED1 is required for optimal IL-33-induced IL-8 and IL-6 production. This discovery provides additional support to the concept that the TMED family members are important players in innate immune signaling. - Source: PubMed
Publication date: 2013/01/14
Connolly Dympna JO'Neill Luke A JMcGettrick Anne F