Ask about this productRelated genes to: TLE1 Blocking Peptide
- Gene:
- TLE1 NIH gene
- Name:
- TLE family member 1, transcriptional corepressor
- Previous symbol:
- -
- Synonyms:
- ESG1, GRG1, ESG
- Chromosome:
- 9q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-13
- Date modifiied:
- 2018-11-15
Related products to: TLE1 Blocking Peptide
Related articles to: TLE1 Blocking Peptide
- Irritable bowel syndrome (IBS) is a common gut-brain axis disorder characterized by abdominal pain and altered bowel habits, and it shows high comorbidity with psychiatric disorders. However, the shared genetic mechanisms underlying these associations remain incompletely understood. - Source: PubMed
Publication date: 2026/05/14
Ye WeiyiDing HuanxinPeng BichenWang XianjinCheng YugangZhang GuangyongYu HongweiUllah KalimChang XiaoWang XiaoyanWang Zhiyu - Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) poses a considerable challenge for the long-term treatment of non-small cell lung cancer (NSCLC). This study aims to identify a novel biomarker associated with osimertinib resistance and explore its role in EGFR-TKI resistance in lung adenocarcinoma (LUAD). - Source: PubMed
Publication date: 2026/05/28
Chen NaWang TianlinLi YiZhang RuixiaWei XiduanWang Zhenglu - - Source: PubMed
Ji Y PZhang J HZhou YWang Y FWang S YLin LWang JZhai C W - Primary cardiac synovial sarcoma (PCSS) is an exceedingly rare tumor. This study presents a comprehensive analysis of six novel PCSS cases identified within our institutional cohort, compared with published literature cohorts, focusing on their clinical presentations, histopathological features, immunohistochemical and molecular characteristics, therapeutic interventions, and prognosis. Our institutional cohort included five male and one female patients, with a median age of 44 years. Presenting symptoms included dyspnea, chest tightness, back pain, and syncope. Tumors were located in the pericardium (four cases) and the cardiac wall (two cases). The tumor size ranged from 2.0 to 14.5 cm. Histopathologically, four cases were monophasic and two were biphasic. Immunohistochemical analysis revealed consistent expression of TLE1, vimentin, and BCL-2. Molecular analysis confirmed the presence of the gene fusion through fluorescence in situ hybridization (FISH) in five cases, whereas one FISH-negative case was positive for the gene fusion through next-generation sequencing (NGS). All patients underwent surgical intervention (tumor excision) followed by adjuvant chemotherapy with doxorubicin and ifosfamide. At follow-up, four patients were alive without disease and two had died. This case series highlights the clinicopathologic and molecular features of PCSS. Overall, gene rearrangement and TLE1 expression are crucial diagnostic markers for differentiating PCSS from other neoplasms. - Source: PubMed
Publication date: 2026/04/13
Cai Yi-XiangLiu Sheng-JunSun QiLi HuiMeng Xiao-Le - Papillary thyroid carcinoma (PTC) represents the most prevalent sort of thyroid malignancy, and its incidence has been consistently increasing worldwide. Although most PTC cases exhibit indolent behavior, a subset demonstrates aggressive characteristics, leading to recurrence, metastasis, and poor clinical outcomes. This study aims to unveil the molecular mechanism of PTC and identify potential biomarkers for its early diagnosis and individualized treatment. - Source: PubMed
Publication date: 2026/03/24
Zhai XinyuGu XueZhang ShengcanHuang HanzhaoYe Hui