Ask about this productRelated genes to: CHRND Blocking Peptide
- Gene:
- CHRND NIH gene
- Name:
- cholinergic receptor nicotinic delta subunit
- Previous symbol:
- ACHRD
- Synonyms:
- -
- Chromosome:
- 2q37.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-02-04
Related products to: CHRND Blocking Peptide
Related articles to: CHRND Blocking Peptide
- : The Qingyuan partridge chicken is a high-quality local chicken breed in China. Its weight gain directly affects breeding efficiency. This study used RNA sequencing to analyze gene expression dynamics in the breast muscle tissue of Qingyuan partridge chickens at 1, 35, 70, and 105 days of age. : This study employed RNA-sequencing, integrated with differential expression analysis, weighted gene co-expression network analysis (WGCNA), and short time-series expression miner (STEM) analysis, to systematically investigate the transcriptomic dynamics in breast muscle tissue across four developmental stages. : Phenotypic analysis revealed a significant increase in both body weight (BW) and breast muscle weight with age ( < 0.05). Transcriptomic analysis identified 3521 genes specifically expressed at the age of one day compared with the other 3 ages. These were significantly enriched in pathways related to ribosomal biosynthesis, cytoskeletal regulation, and cell proliferation ( < 0.05). Turquoise and black modules were identified by WGCNA, containing 1563 hub genes, which significantly correlated with BW. Integration of differentially expressed genes and STEM analysis selected 26 BW-related key genes closely associated with muscle growth, including calmodulin 2 (), heat shock protein 90 alpha family class A member 1 (), and cholinergic receptor nicotinic delta subunit (). Protein-protein interaction analysis revealed two functional networks centered around these genes. Enrichment analysis of the STEM profiles indicated that upregulated genes were significantly enriched in autophagy and the ErbB, FoxO, mTOR, and insulin signaling pathways, while genes related to the ribosome, cell cycle, and PPAR signaling pathways were downregulated. : This study identified BW-related key genes and pathways, enriching our knowledge of the functional maintenance of chicken BW. - Source: PubMed
Publication date: 2026/01/31
Zhuang JunyiYang WeifangChen YanjiLiu ShuangHe XuchengDeng JiguangZhang YuchengZheng MaiqingZhao GuipingWen JieCui Huanxian - Disuse-induced muscle atrophy commonly occurs following illness, injury, or falls and becomes increasingly frequent with ageing. Whether skeletal muscle retains a "memory" of repeated disuse remains unknown. We investigated repeated lower-limb immobilization in young adults and a refined aged rat model, integrating physiological, multi-omic, immunohistochemical, biochemical, and primary human muscle stem cell (MuSC) analyses. To enable robust age comparisons, we integrated previously published young rat data with newly generated aged rat data. In young human muscle, repeated disuse elicited attenuated transcriptional perturbations in oxidative and mitochondrial pathways, suggestive of a protective molecular memory, despite similar atrophy to initial disuse. In contrast, aged muscle exhibited a detrimental memory, characterized by greater atrophy, exaggerated suppression of aerobic metabolism genes despite recovery after initial disuse, NAD and mitochondrial DNA depletion, and activation of proteasomal, extracellular-matrix, and DNA-damage pathways. Whereas young rats recovered muscle mass after initial disuse, aged rats failed to do so. Across species, repeated disuse induced DNA hypermethylation and downregulation of aerobic metabolism and mitochondrial gene networks. NR4A1 and NR4A3 were among the strongest disuse-suppressed genes; NR4A1 acquired recovery-phase hypermethylation that maintained its transcriptional repression, while NR4A3 was the most downregulated gene after initial atrophy and remained persistently suppressed into recovery. Acetylcholine receptor subunit genes (CHRNA1, CHRND) were epigenetically primed, demonstrating hypomethylation and strong upregulation after disuse, and further amplification after repeated atrophy, while CHRNG was selectively induced after repeated atrophy only. NMRK2, an NAD biosynthesis gene, was the most downregulated gene across both atrophy periods, and supplementation with its substrate, nicotinamide riboside (NR), improved myotube size in MuSCs derived post-atrophy. Overall, repeated disuse atrophy imprints a molecular memory in skeletal muscle shaping transcriptional resilience in young adults and exaggerated susceptibility in aged muscle. - Source: PubMed
Publication date: 2026/02/25
Turner Daniel CRaastad TrulsUllrich MaxChristiansen Stian FSutherland HazelBoot JamesWozniak EvaMein CharlesDalbram EmilieTreebak Jonas TOwens Daniel JHughes David CBodine Sue CJarvis Jonathan CSharples Adam P - Opioid dependence (OD) is epidemic in the United States and it is associated with a variety of adverse health effects. Its estimated heritability is ~50% in twin studies, and recent genome-wide association studies have identified more than a dozen common risk variants. However, there are no published studies of rare OD risk variants. In this study, we analyzed whole-exome sequencing data from the Yale-Penn cohort, comprising 2100 participants of European ancestry (EUR; 1321 OD cases) and 1790 of African ancestry (AFR; 864 cases). A novel low-frequency variant (rs746301110) in the RUVBL2 gene was identified in EUR (p = 6.59 × 10). Suggestive associations (p < 1 × 10; not passing the Bonferroni correction) were observed in TMCO3 in EUR, in NEIL2 and CFAP44 in AFR, and in FAM210B in the cross-ancestry meta-analysis. Gene-based collapsing tests identified SLC22A10, TMCO3, FAM90A1, DHX58, CHRND, GLDN, PLAT, H1-4, COL3A1, GPHB5 and QPCTL as top genes (p < 1 × 10) with most associations attributable to rare variants and driven by the burden of predicted loss-of-function and missense variants. This study begins to fill the gap in our understanding of the genetic architecture of OD, providing insights into the contribution of rare coding variants and potential targets for future functional studies and drug development. - Source: PubMed
Publication date: 2025/10/06
Wang LuNuñez Yaira ZMartínez-Magaña José JaimeRivera-Hernandez MelodyMao ZhongzhengBrennand Kristen JMontalvo-Ortiz Janitza LKranzler Henry RGelernter JoelZhou Hang - - Source: PubMed
Min Je HongSohn Sung-YeonKim Shin YeopJoo In Soo - The adult nicotinic acetylcholine receptor in muscle is a pentameric complex composed of four transmembrane subunits, and these are encoded by CHRNA1, CHRNB1, CHRND, and CHRNE, respectively. There were only a few case reports of congenital myasthenic syndromes due to CHRNA1, CHRNB1, and CHRND. We aimed to share phenotypic and genotypic features of the patients. - Source: PubMed
Publication date: 2025/08/05
Guan JingZhang MinHu ChaopingZhao LeiZhang LinmeiLi XihuaWang YiZhou ShuizhenLi Wenhui