Ask about this productRelated genes to: XYLT1 Blocking Peptide
- Gene:
- XYLT1 NIH gene
- Name:
- xylosyltransferase 1
- Previous symbol:
- -
- Synonyms:
- XT-I, PXYLT1
- Chromosome:
- 16p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-06
- Date modifiied:
- 2016-10-05
Related products to: XYLT1 Blocking Peptide
Related articles to: XYLT1 Blocking Peptide
- Fine particulate matter 2.5 (PM) is linked to rising cases of respiratory, cardiovascular, and immune-mediated diseases and increased hospitalizations in non-respiratory patients. Chiang Mai Province in Northern Thailand, faces seasonal severe PM pollution, but its impact on immune responses in human remains poorly characterized. This study aimed to investigate the association between air pollution and non-communicable diseases in Chiang Mai and to assess how PM collected in Chiang Mai (CM-PM) during the peak of poor air quality in 2020 affected the innate immune responses of primary human monocytes. PM, PM, NO, and O air quality index (AQI) levels concurrently increased throughout the year. Notably, PM and NO AQI levels were positively correlated with the incidence of chronic obstructive pulmonary disease (COPD) in Chiang Mai. Transcriptomic profiling of primary human monocytes stimulated with CM-PM (5 and 20 μg/ml) for 24 h indicated a dose-dependent effect on gene expression profiles. Alterations in pyrimidine ribonucleotide metabolism were observed at both CM-PM concentrations. Upregulation of key metabolic genes (CYP1B1, HK2, and XYLT1) and suppression of glycolytic activity were observed with treatment of 20 μg/ml of CM-PM. This study provides strong evidence that exposure to PM disrupts metabolism and alters responses of human innate immune cells which may contribute to increased severity of respiratory diseases. - Source: PubMed
Publication date: 2026/06/11
Sangphech NaunpunChetwittayachan TassaneeLertmemongkolchai GanjanaMudway IanLaksee SakchaiMeerak JomkhwanPongpanitanont PongphanPalaga Tanapat - Proteoglycans are a major component of the connective tissue matrix, which consists of a core protein and covalently attached glycosaminoglycan (GAG) chains, which are highly sulfated polysaccharides with a tetrasaccharide linker for the core protein attachment. Impaired synthesis or degradation of GAG causes genetic disorders. In the 1950s, deficient lysosomal GAG degradation was discovered in mucopolysaccharidoses. In the 1990s, a defective enzyme for GAG synthesis was implicated in a variant of Ehlers-Danlos syndrome and an impaired GAG sulfation in diastrophic dysplasia. Newer studies have uncovered that abnormal GAG synthesis causes a large group of genetic skeletal disorders with joint and skin abnormalities. - Source: PubMed
Publication date: 2026/02/26
Tsujioka YukoSimsek Kiper Pelin OzlemUnger SheilaHanda AtsuhikoKono TatsuoJinzaki MasahiroRossi AntonioSuperti-Furga AndreaNishimura Gen - Non-small cell lung cancer (NSCLC) remains a leading cause of global mortality, necessitating novel therapies. This study investigated the therapeutic role of natural killer cell-derived exosomes (NK-Exo), whose antitumor mechanisms are incompletely understood. Exosomes were isolated from interleukin (IL)-2-independent NK-92MI cells via differential ultracentrifugation and characterized by nanoparticle tracking, electron microscopy, and western blotting. They exhibited cup-shaped morphology (50–150 nm), expressed CD81/TSG101, and demonstrated selective cytotoxicity against tumor cells (A549, A375) but not nontumor cells (293 T) in vitro; this effect was corroborated in patient-derived lung organoids. Small RNA sequencing revealed miR-140-3p as highly enriched in NK-Exo, and its expression correlated with improved survival in patients with NSCLC. Functional validation showed that overexpressing miR-140-3p enhanced NK-Exo cytotoxicity and directly inhibited cancer cell migration and invasion, whereas inhibiting miR-140-3p promoted tumor growth. Mechanistically, miR-140-3p directly targeted xylosyltransferase 1 (XYLT1), as confirmed by dual-luciferase assay, leading to reduced levels of heparan sulfate proteoglycan 2 (HSPG2). Knockdown of XYLT1 phenocopied the tumor-suppressive effects of miR-140-3p, while supplementation with heparan sulfate reversed them. In a Lewis lung carcinoma mouse model, intratumoral delivery of NK-Exo, miR-140-3p mimic, or XYLT1 Small interfering RNA (siRNA) significantly inhibited tumor growth and alleviated splenomegaly. In conclusion, NK-Exo deliver miR-140-3p to suppress tumors via the novel miR-140-3p/XYLT1/HSPG2 axis, presenting a promising therapeutic strategy for cancer. - Source: PubMed
Publication date: 2026/04/11
Li DingruChen ZeruiLiang HerongLi QiangMao XiaofanZhang BeiyingGu WeiquanXiao YeXiong Xing-DongZhou DanDeng YuhuaCai Mengyun - Cattle domestication and subsequent breed formation have profoundly shaped agricultural economies and ecological adaptation worldwide. Among these, Chinese indigenous breeds exhibit extensive phenotypic diversity driven by complex admixture histories. Hetian cattle, a native population from the arid Xinjiang Province of China, possess superior traits including drought tolerance and disease resistance. Despite their ecological and agricultural importance, the genomic architecture and adaptive mechanisms underpinning these traits remain poorly characterized. - Source: PubMed
Publication date: 2025/11/26
Liu XueweiLiu TianyongWang YihuaDong HongLi FuqiangQi XingshanLuo YongmingJiang YiAhmed ZulfiqarLei ChuzhaoGuo Xiang - Periodontitis is a multifactorial inflammatory disease whose pathogenesis is associated with intricate interactions between genetic and environmental factors. Leveraging electronic health records data from the All of Us Research Program, we stratified periodontitis by clinically relevant dimensions: stage, grade, and extent. Based on these phenotypes, we performed a multi-ancestry genome-wide association study, focusing on predominant ancestry populations of African, European, and Admixed American. Our study cohort comprised 3,881 periodontitis patients and a control group of 10,760 patients with dental caries and without periodontitis. Ancestry-specific GWAS revealed significant genetic associations (P<5×10) in periodontitis grade phenotypes at the LINC00294 and CLMN loci in the African ancestry population and also confirmed via the multi-ancestry meta-analysis. In addition, the XYLT1 locus emerged as a significant signal associated with periodontitis grade phenotype in the admixed American GWAS. Our GWAS comparing periodontitis to dental caries in the admixed American population identified several significant loci, including RABGAP1L, previously linked to immune regulation, DCHS2, a cadherin-related gene involved in bone mineralization and tissue morphogenesis, and OSTM1, known to be crucial for bone remodeling. The findings of our study highlight the potential of integrating EHR and genomic data from large-scale biobanks to achieve informative dental phenotyping, uncover novel molecular insights into periodontal disease, and personalize treatment approaches. - Source: PubMed
Publication date: 2025/09/08
Sanders KeithNaseri ArdalanLee Chun-TehIwata JunichiHe YixuanTokede BunmiWalji MuhammadZhi DeguiRasmy Laila