Ask about this productRelated genes to: RPS7 Blocking Peptide
- Gene:
- RPS7 NIH gene
- Name:
- ribosomal protein S7
- Previous symbol:
- -
- Synonyms:
- S7, eS7
- Chromosome:
- 2p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-07
- Date modifiied:
- 2019-04-23
Related products to: RPS7 Blocking Peptide
Related articles to: RPS7 Blocking Peptide
- Functional inactivation of the tumour suppressor p53 drives therapeutic resistance in non-small cell lung cancer (NSCLC). While targeted protein degradation offers a potential solution, the repertoire of ligandable E3 ligases remains limited. This study aimed to identify and characterise 2,6-didehydroxyspeperomin B (DPB) as a novel covalent molecular glue that targets p53-deficient NSCLC and to elucidate its mechanism of action involving the E3 ligase MKRN2. - Source: PubMed
Publication date: 2026/04/16
Pan YuqiHua ShengjieYang RuolanHe QinmanXu YanJiang ZeyuGong XiaoyangZhang ShuruiWang XiaoYu HongliWu HaoWen HongmeiWang PinHang BoWang Xinzhi - Valeriana fauriei and V. dageletiana are traditional medicinal plants known for their calming effects and use in alleviating insomnia. However, genomic information for these species is limited. This study aimed to sequence and characterize the complete chloroplast genomes of V. fauriei and V. dageletiana, and to compare them with those of closely related Valeriana species to investigate structural variation, molecular evolution, and divergence history. The chloroplast genomes of V. fauriei, V. dageletiana, and V. jatamansi were highly conserved in overall structure. Minor differences were observed in tandem repeat regions and sequence divergence hotspots, particularly within accD, rps18, and the trnN-trnL intergenic region. Analysis of 57 protein-coding genes from four species revealed that most genes are under strong purifying selection. However, elevated dN/dS ratios in psbI, rps7, and rpl23 suggest potential lineage-specific divergence. Phylogenetic reconstruction showed that V. fauriei and V. dageletiana form a clade with V. officinalis, whereas V. jatamansi is an earlier diverging lineage. Divergence time estimation indicated that V. officinalis split from this clade 0.4255 to 1,0839 million years ago, and that V. fauriei and V. dageletiana diverged approximately 0.0205 million years ago. These results provide insights into the evolution of Valeriana chloroplast genomes, highlighting both structural conservation and species-specific variation. The findings contribute to a better understanding of recent speciation events and molecular evolution in this genus, supporting future phylogenomic and taxonomic studies of Valeriana species. - Source: PubMed
Publication date: 2026/03/17
Jeong SuminKim Yong-GooKim YeseulNam Bo-MiPark Yun JiJin Byung JunPark Inkyu - Caprifoliaceae is a cosmopolitan plant family encompassing a large number of species, with significant economic and ecological values. Species divergence and adaptation in Caprifoliaceae are not well understood due to extensive hybridization and rapid radiation. Here, we assembled and compared the complete mitochondrial genomes of Kolkwitzia amabilis and Triplostegia glandulifera, which are distributed in distinct habitats with unique life forms, to elucidate the structural variation of mitogenomes and their implications for species divergence and environmental adaptation. The mitochondrial genome of K. amabilis consists of two circular molecules with sizes of 540,375 bp and 197,940 bp, respectively, while T. glandulifera has a single circular genome of 642,933 bp. The two genomes exhibit a similar preference for A/U bases in codon usage, mainly driven by natural selection, but present significant differences in mode and the number of repeat types. Among 25 shared genes in six Caprifoliaceae species, atp1 had the highest nucleotide diversity; meanwhile, atp4, ccmB, and mttB were under positive selection. Notably, rps7 in T. glandulifera had potentially undergone species-specific positive selection. A phylogenetic tree of Caprifoliaceae species based on 19 conserved protein-coding genes (PCGs) showed that K. amabilis and T. glandulifera formed a sister group, providing molecular evidence at the mitogenome level for the systematic classification of plants in this family. Furthermore, analyses of ancestral genome reconstruction indicated that both mitogenomes exhibited significant gene order rearrangements and gene deletions, and their duplication patterns of nad1 and nad2 genes differed from those of other Caprifoliaceae species, suggesting that dynamic structural changes were an important feature of mitogenome evolution in Caprifoliaceae. In conclusion, the firstly reported mitogenomes of two distinctive species provided important molecular data for phylogenetic, genomic evolution, potential divergence and adaption in Caprifoliaceae. - Source: PubMed
Publication date: 2026/03/14
Wang JiangtaoRen MiaozhenZhao MiaomiaoDu HuiyueHuang ShiningWang ShiyiHou RuiwenJiang XinYan ChunliLi JianfangLiu Zhan-Lin - The legume genus Vicia L. (Fabaceae) is of significant ecological and agronomic importance, comprising species widely utilized as forage crops, green manure, and sources of valuable phytochemicals. Despite this, a comprehensive genomic understanding of many species, particularly those endemic to underrepresented regions like Iran, remains limited. To address this, we employed a high-throughput sequencing and comparative genomics approach to elucidate the chloroplast (cp) genome architecture and evolutionary relationships of seven previously uncharacterized Iranian Vicia species including V. hirsuta, V. hybrida, V. lathyroides, V. lutea, V. narbonensis, V. peregrina, and V. villosa. Total genomic DNA was sequenced on an Illumina HiSeq 2000 platform, and the cp genomes were assembled de novo using GetOrganelle, followed by comprehensive annotation with a suite of bioinformatic tools. The analysis revealed considerable size variation, ranging from 118,660-130,223 bp, and a key structural divergence involving the loss of one inverted repeat (IR) region in six species, consolidating their placement within the IR-lacking clade (IRLC), while V. villosa retained the ancestral quadripartite structure. Lineage-specific gene losses were documented, including accD in V. lathyroides and ycf2 in V. narbonensis. Microsatellite analysis identified a predominance of A/T-rich mononucleotide simple sequence repeats (SSRs), with V. hybrida exhibiting the highest SSR density. Nucleotide diversity (Pi) analysis across coding regions identified clpP (Pi = 0.19772) and ycf1 (Pi = 0.16964) as hypervariable loci, while the ribosomal protein genes rps7 and rpl20 were validated as highly effective phylogenetic barcodes. Maximum likelihood phylogenetic reconstruction, based on a concatenated alignment of 86 shared protein-coding genes, resolved the species into well-supported clades, providing a robust evolutionary framework. This study delivers essential genomic resources that deepen the understanding of cp genome evolution in the IRLC and provides powerful molecular tools for future research in Vicia systematics, conservation genetics, and precision breeding. - Source: PubMed
Publication date: 2026/03/04
Golchini Mohammad MehdiSoorni Aboozar - During the switch from progenitor to differentiated cell, cellular physiology must change to accommodate increased translation and trafficking of membrane-bound proteins. We identify RNA-binding and E3 ubiquitin ligase Mex3a as a key driver of proper neuronal differentiation by regulating mRNA translation and trafficking of cell surface proteins in the context of Unfolded Protein Response (UPR) signaling. Loss of Mex3a in immature olfactory sensory neurons (OSNs) leads to defects in cilia structure, cell surface protein expression, and planar cell polarity in mature OSNs. Proteomics reveal a Mex3a-dependent decrease in proteins related to vesicle transport, lipid metabolism, and ribosome biogenesis. We identify RNA and ubiquitin targets of Mex3a and provide evidence that Mex3a may confer K27 ubiquitin linkage on substrates. Finally, modulating cellular levels of Mex3a changes the recruitment of translation factors Serbp1 and p-eEF2 to ribosomes with possible effects on translation. Our data reveal how a stemness factor regulates development post-transcriptionally and post-translationally to ensure robust differentiation. - Source: PubMed
Publication date: 2026/02/09
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