Ask about this productRelated genes to: EWSR1 Blocking Peptide
- Gene:
- EWSR1 NIH gene
- Name:
- EWS RNA binding protein 1
- Previous symbol:
- -
- Synonyms:
- EWS
- Chromosome:
- 22q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-04-25
Related products to: EWSR1 Blocking Peptide
Related articles to: EWSR1 Blocking Peptide
- Hyalinizing clear cell carcinoma (HCCC) is a rare tumor. Most lesions arise in the salivary gland; however, other primary sites include the nasal and oral cavities, and rarely lung. Lesions are characterized by tumor lobules with pale or clear cytoplasm, arranged in nests or cords, surrounded by a mixed hyalinized and fibrocellular stroma. EWSR1-ATF1 gene fusion is often reported in these lesions. Typically, HCCC bears a good prognosis. We report a unique case of primary lung HCCC (PLHCCC) with cutaneous metastasis and aggressive clinical course. To the best of our knowledge, cutaneous metastasis by PLHCCC has not been previously observed and may signal an aggressive clinical course with poor prognosis. - Source: PubMed
Publication date: 2026/05/05
Gustafson David MTiwari SansarChung Catherine G - Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland malignancy with variable malignant potential. Only 8 cases studied by fine needle aspiration have been reported in the literature. We have observed axillary metastasis in a patient with oropharyngeal HCCC. Smears were cellular and composed of middle-sized, oval cells with round and ovoid hyperchromatic nuclei without atypia. Some mitotic figures and intranuclear cytoplasmic inclusions were present. Most of the cells exhibited dense and occasionally clarified cytoplasm. Tumor cells were mostly arranged in loose clusters rich in rosette-like formations and naked nuclei. FISH revealed EWSR1 translocation. Comparing our case with 8 previously reported cases, it is evident that it is possible to make the diagnosis of HCCC on smears, especially when EWSR1 translocation is present. - Source: PubMed
Publication date: 2026/05/05
Cedor KatarzynaLesnik MariaKlijanienko Jerzy - Ewing sarcoma belongs to the family of undifferentiated small round cell sarcomas of bone and soft tissue. It is characterized by a gene fusion involving EWSR1 and an ETS-family transcription factor gene. In 85-96% of cases, a specific chromosomal translocation results in the EWSR1-FLI1 fusion gene, whose product functions as an oncogene essential for tumorigenesis. Ewing sarcoma is most common in adolescents and young adults. It primarily affects the diaphyses of long bones, the pelvis, and the axial skeleton, although extraosseous involvement is not uncommon. This is a highly malignant neoplasm, and in most cases, micrometastases are already present at the time of diagnosis. The treatment is multimodal and includes local therapy (surgery and/or radiotherapy) and systemic chemotherapy. One of the greatest therapeutic challenges remains the long-term systemic control of the disease. To improve overall survival - especially in high-risk patients - innovative treatment strategies are essential, as the potential for intensifying chemotherapy has reached its limit due to treatment-related toxicity. Both diagnostic and therapeutic management should take place in specialized sarcoma centers. - Source: PubMed
Nohejlová Medková APacas PKopečková K - The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib delays disease progression in dedifferentiated liposarcoma (DDLPS) by inducing tumor cell quiescence or senescence, though most tumors ultimately progress. Preclinical data suggest CDK4/6 inhibition enhances intratumoral inflammation and may synergize with immune checkpoint inhibitors. - Source: PubMed
Publication date: 2026/05/04
Rosenbaum EvanSeier KennethGularte-Mérida RodrigoSeffar EvanDickson Mark AAvutu ViswatejBanks Lauren BChan Jason EChi PingGounder Mrinal MKelly Ciara MKeohan Mary LMaki Robert GMovva SujanaReed DamonDesir RhoenaBiniakewitz MatthewCho Jae-MunDuchemin MicheleErinjeri Joseph PLefkowitz Robert AKoff AndrewSinger SamuelTap WilliamQin Li-XuanD'Angelo Sandra - Hyalinizing clear-cell carcinoma (HCCC) is a rare malignant tumor of the minor salivary glands characterized by nests of clear cells within a hyalinized stroma. Its diagnosis remains challenging due to its histological similarity to other neoplasms, and the recent recognition of distinct molecular features, such as Ewing sarcoma breakpoint region 1 (-activating transcription factor 1 () fusion. This report describes a rare case of HCCC arising from the tongue with confirmed fusion. - Source: PubMed
Publication date: 2026/05/01
Sakuma KanameTakahashi HarukaHanada DaichiKikuchi YosukeOno JunyaToya ShujiOkada YasuoTanaka Akira