Ask about this productRelated genes to: CHFR Blocking Peptide
- Gene:
- CHFR NIH gene
- Name:
- checkpoint with forkhead and ring finger domains
- Previous symbol:
- -
- Synonyms:
- FLJ10796, RNF196
- Chromosome:
- 12q24.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-14
- Date modifiied:
- 2017-12-06
Related products to: CHFR Blocking Peptide
Related articles to: CHFR Blocking Peptide
- Gastric cancer (GC) is one of the most lethal malignancies worldwide, and hepatic metastasis is a major cause of its poor clinical prognosis. The stemness regulator octamer-binding transcription factor 4 (OCT4) drives the migration, invasion and metastasis of GC cells. As a RING-type E3 ubiquitin ligase, Checkpoint with Forkhead-associated and RING finger domains (CHFR) has been identified as a key promoter of metastasis in advanced GC. However, the precise molecular mechanisms underlying CHFR-mediated modulation of GC metastasis remain unclear. - Source: PubMed
Publication date: 2026/08/19
Dai MugenWang JianboXu QingShao YixiuWang HanWu XiaomengPan JundiYe Bin - Pathogenic variations in DNA checkpoint kinases, cell cycle regulation, and DNA-damage repair genes are responsible for hereditary cancer predisposition. In a woman with a history of multiple primary cancers (carcinoma rectum and papillary carcinoma of thyroid) at a young age, whole exome sequencing (WES) of the blood revealed a likely pathogenic germline variation NM_001161346.2(CHFR):c.1231C[T (ClinVar variation ID: 1802254) in the gene. The CHFR gene encodes an E3-ubiquitin ligase and is required for antephase checkpoint maintenance and cell cycle entry into mitosis. It has previously been shown to be silenced in many human tumour types, including colon, lung, and esophageal tumours. Herein, we describe what is possibly the first case of CHFR-related hereditary cancer predisposition syndrome and, using RNA sequencing, elucidated the pathways associated with CHFR inactivation. - Source: PubMed
Chirravuri-Venkata RamakanthBhowmik Aneek DasNemalikanti MaliniMishra SuryanarayanSingha BishwadeepUndamatla ValliRaju Kataru ChandreswaraA ShreyKola RamyasriSowpati Divya TejRanganath PrajnyaTallapaka Karthik Bharadwaj - Lung cancer (LC) is a well-known cause of cancer-related death worldwide. Early diagnosis of LC is an unmet need to improve the treatment response. In present study, we have analyzed the promoter methylation of a panel of genes in LC tissue and established tissue mirror biomarkers in plasma-derived circulating cell-free DNA (cfDNA). The mRNA expression of panel of genes ( and ) were analyzed in tumor tissue (TT) including Non-Small Cell Lung Cancer (NSCLC), and Small Cell Lung Cancer (SCLC) as compared to tumor-free tissue (TF) and correlated with gene promoter methylation in tissue-derived gDNA using methylation-specific PCR. The methylation analysis of genes were further analyzed in plasma-derived cfDNA of NSCLC and SCLC compared to healthy control. The methylation frequencies of and were significantly higher ( < 0.05 to < 0.001) in TT (59.45, 45.94 and 72.97%) compared to TF (21.42, 14.28 to 28.57%) respectively. Gene expressions in TT were down-regulated ( < 0.01) in contrast to TF and negatively correlated ( < 0.001) with hypermethylation, except which showed up-regulation with hypomethylation in TT of NSCLC. The methylation status in cfDNA exploits similar results as tissue sample, exhibited significant hypermethylation ( ≤ 0.05 to ≤ 0.001) in cfDNA of LC as compared to healthy control, and showed 58.33 to 76.47% positive predictive value and 51.47 to 66.33% negative predictive value. This study illustrated that gene promoter methylation analysis of the panel of genes in plasma samples has the potential for diagnosis of LC, and can be used as a tissue mirror biomarker. - Source: PubMed
Publication date: 2024/07/30
Karpathak SupriyaGarg RajivAhmad Mohammad KaleemSrivastava AnandQidwai TabishUbaid SabaSrivastav Anurag Kumar - Existing imaging and serum-marker assays miss many early liver cancers, especially in high-risk chronic liver disease carriers. We aimed to create a highly accurate, non-invasive, methylation-based liquid biopsy for early detection. - Source: PubMed
Zhang RuohanYang XinrongLi GuangmingDeng YinanLiu JibingGao HongjunZhao JieCheng JianwenZhao XiaofeiYang YangWu ZhenGu ShuangzhenWu YangMa ZhongyingLiu YanliKang YanZhou GuangpengLi HuaZhang YonghongHan XiaoliangFan JiaZhou JianDou KefengTao Kaishan - The link between neurodevelopment in infants exposed to maternal gestational diabetes mellitus (GDM) and fetal DNA methylation remains unexplored. We conducted this hypothesis-generating study to investigate the association between fetal DNA methylation and neurodevelopmental outcomes in children of mothers with GDM. We carried out a prospective, observational pilot cohort study comparing infants exposed to maternal GDM with an unexposed control group. Umbilical cord blood DNA methylation was assessed using targeted methylome sequencing covering 3.34 million CpG sites. Infant neurodevelopment was evaluated at age two years using the Bayley-III Scales. Bioinformatics processing identified differentially methylated regions (DMRs), followed by multiple enrichment analyses of DMR-associated genes and partial correlation analyses. Multi-dimensional enrichment analysis of the 1053 identified DMR-associated genes revealed a significant convergence of pathways related to neurogenesis, synaptic components, and axonal guidance. Infants born to mothers with GDM exhibited lower scores in cognitive, language, and motor domains, which were associated with identifiable DNA methylation signatures at birth. Significant correlations were observed in genes essential for brain scaffolding and synaptic circuitry, most notably , the alpha/beta clusters, and . Additionally, methylation patterns in and suggest a potential impact on blood-brain barrier integrity, while associations with and highlight a systemic metabolic 'cross-talk' influencing neurodevelopment. Although these pilot findings are hypothesis-generating and require further functional validation, this study provides pioneering evidence that neurodevelopmental alterations in the offspring of mothers with GDM are potentially associated with intrauterine epigenetic modifications detectable at birth. - Source: PubMed
Publication date: 2026/04/16
González-González Nieves LuisaArmas-González MarinaGonzález-Dávila EnriqueCastro-Conde José RamónGonzález-Campo CandelariaFlores CarlosLorenzo-Salazar José MiguelGonzález-Montelongo RafaelaMuñoz-Barrera AdriánPadrón-Pérez ErikaTascón-Padrón LauraOrribo-Morales Olivia