Ask about this productRelated genes to: SLC25A44 Blocking Peptide
- Gene:
- SLC25A44 NIH gene
- Name:
- solute carrier family 25 member 44
- Previous symbol:
- -
- Synonyms:
- FLJ90431, KIAA0446
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2006-09-21
- Date modifiied:
- 2015-12-08
Related products to: SLC25A44 Blocking Peptide
Related articles to: SLC25A44 Blocking Peptide
- A genome-wide knockout screen identified members of the SLC25 family of mitochondrial carrier proteins as important regulators of the rate of de novo mitochondrial protein synthesis. To elucidate this relationship, we generated human cell knockouts for SLC25A25, SLC25A44, SLC25A45, and SLC25A48, which have been shown to exchange adenosine triphosphate-magnesium (ATP-Mg) and phosphate, branched-chain amino acids, methylated basic amino acids, and choline, respectively. Multiomic and functional analyses identified that these four carriers are crucial for mitochondrial translation, biogenesis and function of the oxidative phosphorylation system, as well as mitochondrial morphology. Thermostability screens showed that SLC25A48 is specifically stabilized by choline, and changes in the mitochondrial metabolome and lipidome indicated defects in choline biosynthetic pathways and remodeling of mitochondrial membranes, both consistent with SLC25A48 being a choline transporter. These results highlight the essential roles of specific SLC25 transporters in maintaining mitochondrial structure and function and show that impaired transport of branched-chain amino acids, methylated basic amino acids, ATP-Mg, and choline affects mitochondrial translation. - Source: PubMed
Publication date: 2026/02/25
Rudler Danielle LHughes Laetitia AKing Martin SBaker JessicaLee Richard GGandadireja Andrianto PSunil AnishaFagan Samuel VPayne BlakeGray NicolaMcCubbin TimKunji Edmund R SRackham OliverFilipovska Aleksandra - Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive desmoplastic stroma that profoundly influences tumor biology and therapeutic response. Cancer-associated fibroblasts (CAF), the major stromal component, exist as heterogeneous populations with both tumor-promoting and tumor-restraining functions. In this issue of Cancer Research, Manoukian and colleagues uncover a previously unrecognized hormonal axis in PDAC, demonstrating that estrogen signaling reprograms fibroblast identity and shapes the tumor microenvironment. Building on prior work identifying an inflammatory CAF subset marked by high OGN and CLEC3B expression (iCAF.1) and associated with favorable prognosis, the authors show that estrogen produced by cancer cells promotes this tumor-restraining phenotype while limiting myofibroblastic CAF activation. Reciprocally, CAF-derived branched-chain amino acids taken up by cancer cells via SLC25A44-mediated uptake fuel estrogen biosynthesis, creating a feedback loop that sustains the classical, less aggressive PDAC subtype. Collectively, these findings establish estrogen as a key modulator of CAF heterogeneity and highlight a novel mechanism of tumor-stroma cross-talk with potential therapeutic implications for stroma-directed interventions in pancreatic cancer. See related article by Manoukian et al., p. 571. - Source: PubMed
Veghini LisaCorbo Vincenzo - Transcutaneous auricular vagus nerve stimulation (taVNS) may exert its anti-obesity effects by promoting the browning of adipose tissue with unclear mechanisms. Modulation of branched-chain amino acid (BCAA) metabolism in adipose tissue may play a key role in this process. In this study, 6 weeks of taVNS significantly reduced body weight gain, body mass index, and the accumulation of inguinal and epididymal white adipose tissue in high-fat diet-induced obese rats, with effects comparable to those of orlistat. Notably, taVNS increased both the content and thermogenic activity of interscapular brown adipose tissue (BAT) in obese rats. Infrared thermal imaging confirmed increased BAT thermogenesis, while transmission electron microscopy indicated improved mitochondrial morphology and function. Molecular analysis revealed that taVNS upregulated uncoupling protein 1, the transporter protein solute carrier family 25 member 44 (SLC25A44), and protein phosphatase Mg2+/Mn2+ dependent 1 K (PPM1K) expression while downregulating branched-chain α-ketoacid dehydrogenase kinase, thereby promoting BCAA metabolism and adipose tissue browning. We conclude that the anti-obesity effects of taVNS are closely related to BCAA metabolism in BAT. These findings highlight taVNS as a promising approach for obesity management, though further studies are needed to clarify the neurobiological pathways involved and advance taVNS technology. - Source: PubMed
Publication date: 2025/05/16
Xin ChenLi ShaoyuanFeng BowenSun LanWang YifeiZhang JinlingZhang YuzhenghengZou NingyiZhou QingRong Peijing - During an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported to modulate macrophage function; however, its role in macrophage alternative activation remain unclear. We aimed to investigate the role of BCAA metabolism in macrophage alternative activation. - Source: PubMed
Publication date: 2024/11/08
Lu ManxiLuo DaZhang ZixuanOuyang FengShi YihongHu ChangyongSu HangLi YiningZhang JiayiGui QianYang Tian-Shu - Although large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. - Source: PubMed
Publication date: 2023/11/20
Archer Derek BEissman Jaclyn MMukherjee ShubhabrataLee Michael LChoi Seo-EunScollard PhoebeTrittschuh Emily HMez Jesse BBush William SKunkle Brian WNaj Adam CGifford Katherine A Cuccaro Michael LPericak-Vance Margaret AFarrer Lindsay AWang Li-SanSchellenberg Gerard DMayeux Richard PHaines Jonathan LJefferson Angela LKukull Walter AKeene C DirkSaykin Andrew JThompson Paul MMartin Eden RBennett David ABarnes Lisa LSchneider Julie ACrane Paul KDumitrescu LoganHohman Timothy J