Ask about this productRelated genes to: MTUS1 Blocking Peptide
- Gene:
- MTUS1 NIH gene
- Name:
- microtubule associated scaffold protein 1
- Previous symbol:
- -
- Synonyms:
- MTSG1, KIAA1288, DKFZp586D1519, FLJ14295, ATIP1, MP44, ATBP, ICIS, ATIP3
- Chromosome:
- 8p22
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-05
- Date modifiied:
- 2018-11-16
Related products to: MTUS1 Blocking Peptide
Related articles to: MTUS1 Blocking Peptide
- : Brain metastasis is associated with poor prognosis in lung adenocarcinoma (LUAD). Anoikis resistance may contribute to tumor cell survival during metastatic dissemination and brain colonization; however, robust biomarkers for prognostic stratification and brain metastasis-associated classification remain limited. This study aimed to investigate anoikis-related molecular features in LUAD brain metastasis and develop a machine learning-based signature for prognostic assessment and exploratory classification of primary and brain-metastatic LUAD samples. : We integrated single-cell and multi-cohort bulk transcriptomic data. Single-cell analysis was performed to characterize anoikis-related cellular states and intercellular communication in primary and brain-metastatic LUAD samples. In the bulk transcriptomic analysis, TCGA-LUAD was used for prognostic feature selection and risk-model construction, and GSE26939 was used for external prognostic validation. The classification performance of the fixed signature for distinguishing primary LUAD from brain-metastatic LUAD samples was further evaluated in GSE161116 and GSE271259. Immune microenvironment features were assessed, and an LLM-assisted exploratory drug-screening strategy combined with molecular docking was used to prioritize candidate compounds. : Single-cell analysis suggested that metastatic epithelial cells exhibited enhanced anoikis-related activity, accompanied by macrophage-associated SPP1-CD44 and MIF-(CD74+CXCR4) communication patterns. Machine learning-based feature selection identified an eight-gene signature consisting of , , , , , , , and . The signature showed prognostic value in TCGA-LUAD and GSE26939 and demonstrated exploratory classification performance in distinguishing primary LUAD from brain-metastatic LUAD samples. High-risk patients exhibited immune microenvironment alterations and enrichment of tumor progression-related pathways. LLM-assisted compound prioritization and molecular docking highlighted resveratrol and SB431542 as hypothesis-generating candidates with predicted interactions with core targets. : This study identified an anoikis-related eight-gene signature for LUAD prognostic stratification and exploratory brain metastasis-associated classification. The findings suggest the potential involvement of anoikis-related tumor-microenvironment interactions in LUAD brain metastasis and provide candidate genes and compounds for further experimental validation. - Source: PubMed
Publication date: 2026/06/17
Wu JunhongZhang BaijunLiu Hengrui - Cisplatin-based chemotherapy is a mainstay treatment for head and neck squamous cell carcinoma (HNSC); however, resistance to cisplatin contributes substantially to poor clinical outcomes. Identifying biomarkers associated with cisplatin response may improve prognostic assessment and treatment selection. - Source: PubMed
Publication date: 2026/05/20
Kim Eun-KyongOh Su YoungChoi So-YoungKim Tae-LynLee Heon-JinKwak SoyoungHong Su-Hyung - fusion is a pathogenic driver factor in lung cancer patients. Currently, the conclusions on the clinical factors of fusion in NSCLC are inconsistent. - Source: PubMed
Publication date: 2026/04/28
Li XiangZhao PeiyanCui HeranZhang TingtingSun WenyuLi Hui - Cardiac fibrosis is a common pathological feature during the progression of various cardiovascular diseases and is characterized by excessive deposition of extracellular matrix (ECM) in the myocardial interstitium, accompanied by alterations in cardiac structure and function. MicroRNAs (miRNAs) play important roles in the regulation of cardiac fibrosis. Previous studies have suggested that miR-34a is involved in fibrotic processes; however, its in vivo effects on cardiac fibrosis and cardiac function, as well as its relationship with mitochondrial tumor suppressor 1 (MTUS1), remain unclear. This study aimed to investigate the effects of miR-34a targeting MTUS1 on cardiac fibrosis and cardiac function in rats through in vivo intervention. - Source: PubMed
Hu JiajiaLu XiaoxuYan JianqinXie ZhongshangZhang JunjieZhang Chengliang - Esophageal squamous cell carcinoma (ESCC) exhibits aggressive malignant behaviors. Microtubule associated scaffold protein 1 (MTUS1) has been recognized as a potential tumor suppressor, yet its roles and functional mechanisms in ESCC remain unclear. - Source: PubMed
Publication date: 2026/03/19
Jiang ChenmingLu QuanlingWang AnChen HaoYao Lishuai