Ask about this productRelated genes to: TUBB6 Blocking Peptide
- Gene:
- TUBB6 NIH gene
- Name:
- tubulin beta 6 class V
- Previous symbol:
- -
- Synonyms:
- MGC4083, HsT1601
- Chromosome:
- 18p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-22
- Date modifiied:
- 2019-03-20
Related products to: TUBB6 Blocking Peptide
Related articles to: TUBB6 Blocking Peptide
- Psoriasis and metabolic dysfunction-associated fatty liver disease (MAFLD) share pathological features such as chronic inflammation, immune dysregulation, and metabolic disturbance. Increasing evidence suggests biological crosstalk between the two conditions, offering new insights into their shared mechanisms and comanagement. Early-stage MAFLD, characterized by hepatic steatosis without evident inflammation or fibrosis, provides a crucial window for intervention. This study aimed to identify early diagnostic biomarkers linking psoriasis and MAFLD. - Source: PubMed
Publication date: 2026/04/15
Wang ShanshanChen YanfangYang TingtingZhang DamingLiu YadiZhang ShenglanYang ZishanWei TuanjieQiu LizhenHuang FangXiao Zhiqiang - BackgroundLactate shapes the tumor microenvironment and modulates immunity. Investigating lactate metabolism genes in renal cell carcinoma (RCC) could elucidate therapeutic targets.MethodsSingle-cell RNA sequencing (GSE242299), bulk RNA sequencing (GSE102101), and spatial transcriptomics (GSE175540) data for RCC were retrieved from GEO. Data processing included quality control, normalization, and dimensionality reduction (R packages). RCTD and CellChat were used for spatial deconvolution and cell-cell communication analysis. CIBERSORT and GSEA evaluated immune infiltration and pathway enrichment. Lactylation scores were derived via single-sample gene set enrichment analysis (ssGSEA) of lactate metabolism genes. Mendelian randomization (MR) assessed gene-cancer risk associations.ResultsMacrophages demonstrated a higher potential for interactions with other cell types due to their extensive receptor-ligand relationships. Lactylation score and MR analysis identified six pivotal genes associated with renal cancer risk: C4A and SERPINA1 were correlated with an elevated disease risk, whereas CD70, FXYD2, SERPINE1, and TUBB6 were associated with a reduced risk. These genes are linked to the degree of immune cell infiltration and can influence the disease process through diverse mechanisms. We also explored the expression profiles of primary genes involved in lactate metabolism in RCC and compared the metabolic pathways between different groups. Notably, experimental validation via tissue microarray immunofluorescence confirmed that the risk-associated genes C4A and SERPINA1 were significantly overexpressed in RCC tumor tissues.ConclusionLactic acid metabolism regulates RCC progression by modulating metabolic activity and immune cell infiltration. Key lactate metabolism genes present novel targets for RCC treatment. - Source: PubMed
Publication date: 2025/12/17
Li JiangboLiu ChenFu ZhiguangHe QiLiu XuSun Zhijia - Mitochondrial autophagy (mitophagy) in macrophages is crucial yet poorly understood within the lung adenocarcinoma (LUAD) tumor microenvironment. This study aimed to identify key macrophage mitophagy-related genes and develop a robust prognostic model for LUAD patients. By integrating single-cell transcriptomics with machine learning algorithms, including LASSO, SVM, and random forest, we identified TUBB6 and CAT as core prognostic genes. A novel risk model based on these genes (RiskScore = 0.225 × TUBB6 - 0.19 × CAT) was constructed and validated, demonstrating that patients in the high-risk group had significantly shorter overall survival (P < 0.001). The high-risk score also correlated with an altered immune microenvironment and increased sensitivity to chemotherapies like cisplatin and gemcitabine. Furthermore, in vitro experiments confirmed that macrophage-specific overexpression of TUBB6 significantly enhanced LUAD cell proliferation, migration, and invasion through secreted factors. Our findings establish a reliable, macrophage mitophagy-based prognostic model and highlight TUBB6 and CAT as novel biomarkers and potential therapeutic targets, offering new avenues for precision medicine in LUAD. - Source: PubMed
Publication date: 2025/11/20
Yang TianRongLiu QinLi WeiPan BinJiang JingFeiTan HongMei - Cilia are microtubule-based organelles found on the surface of most eukaryotic cells. These microtubules are composed of α- and β-tubulin heterodimers, and different tubulin isotypes can confer distinct properties to microtubules. Despite their importance, the contribution of individual tubulin isotype to cilia formation and function remains largely unexplored in vertebrates. Here, we identify a critical role for the β-tubulin isotype Tubb6 in the formation of motile cilia in Xenopus epidermal multiciliated cells (MCCs). Tubb6 mRNA is selectively expressed in MCCs, and its protein product localizes to ciliary axonemes. Loss of Tubb6 leads to a marked reduction in cilia number and length, resulting in defective MCC function. In contrast, mono-motile cilia in the gastrocoel roof plate are unaffected by Tubb6 depletion, suggesting a selective requirement for ciliogenesis in MCCs. Together, our findings uncover a cell type-specific role for Tubb6 in motile cilia formation and highlight the functional specialization of tubulin isotypes in vertebrate cilia assembly. - Source: PubMed
Publication date: 2025/10/11
Xu XiaoluRoss JeanClark FionaWei ShuoSun Jian - Adult-bone homeostasis is maintained through the reciprocal actions of osteoclasts and osteoblasts, which, respectively, resorb and deposit new bone. Excessive osteoclast activity leads to bone loss and contributes to conditions like osteoporosis. Osteoclasts form a specialized adhesion structure called the actin ring that is crucial for bone resorption and relies on both the actin and the microtubule cytoskeletons. Our previous studies identified the β-tubulin isotype TUBB6 as a regulator of actin ring dynamics essential for osteoclast function, and found ARHGAP10, a negative regulator of the GTPases CDC42 and RHOA, as a potential mediator of TUBB6 function. Here we show that ARHGAP10 is a novel microtubule-associated protein critical for osteoclast function. ARHGAP10 directly binds microtubules through its BAR-PH domain, which requires positively charged lysine residues K37, K41, and K44 within the BAR domain. CRISPR/Cas9 mediated knockout of Arhgap10 affects the morphology of the actin ring and impairs osteoclast resorption activity, correlated with altered actin ring dynamics. Complementation experiments reveal that the ability of ARHGAP10 to bind microtubules and to negatively regulate RHO-GTPases are essential for its role in osteoclast resorption activity. These findings uncover a novel cytoskeletal regulator in osteoclasts and suggest that targeting the microtubule-actin interface via ARHGAP10 could represent a therapeutic strategy in bone loss disorder. - Source: PubMed
Publication date: 2025/08/30
Jentschel LauraBlangy AnneBompard Guillaume