Ask about this productRelated genes to: CYP11A1 Blocking Peptide
- Gene:
- CYP11A1 NIH gene
- Name:
- cytochrome P450 family 11 subfamily A member 1
- Previous symbol:
- CYP11A
- Synonyms:
- P450SCC
- Chromosome:
- 15q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: CYP11A1 Blocking Peptide
Related articles to: CYP11A1 Blocking Peptide
- Acrylamide (AA), a widespread environmental and food-borne pollutant, has been classified as a probable human carcinogen. However, its specific role and underlying mechanisms in the progression of prostate cancer (PCa) remain poorly elucidated. This study aims to comprehensively investigate the effect of AA on PCa progression and its molecular mechanisms. - Source: PubMed
Publication date: 2026/06/26
Chen Jia-YinLin Ting-TingZheng Wen-CaiYan Zi-HengLin BinLiu Meng-XinWei YongXue Xue-YiZheng Qing-ShuiKe Zhi-BinXu Ning - L. fruit extract (MFE), which is rich in cyanidin 3-glucoside (C3G), demonstrates antioxidant properties and pharmacological effects, but its reproductive safety remains poorly understood. Polyphenols modulate steroidogenesis, spermatogenesis, and sperm acrosome integrity; therefore, toxicity assessment is needed for use. This study aimed to evaluate the antioxidant profiles and subchronic reproductive effects of MFE. MFE was standardized using high-performance liquid chromatography (HPLC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) assays. Male rats were administered MFE (250 or 500 mg/kg BW) for 56 days. Assessments included computer-assisted sperm analysis (CASA), testosterone, seminal fructosamine, and testicular CYP11A1 and androgen receptor (AR) expression. Acrosomal status was determined using PNA lectin staining. The results showed that MFE contained C3G (119.42 mg/g), antioxidant capacity (DPPH IC: 0.101 mg/mL; FRAP: 465.01 µmol Fe (II)/g), and total contents (phenolics: 41.15 mg GAE/g; flavonoids: 3.15 mg CE/g; anthocyanidins: 11.04 mg C3G/g). MFE did not alter testicular histology and seminiferous stages VII-IX. High doses significantly increased sperm concentration, while both doses reduced sperm beat cross frequency. Testosterone, fructosamine, and CYP11A1/AR expressions showed increasing trends. Significantly, high doses induced a precocious acrosome reaction. In conclusion, MFE has no reproductive toxicity and pro-fertility effects on sperm quantity or androgenic markers, supporting safe subchronic use. - Source: PubMed
Publication date: 2026/06/12
Sawatpanich TarineeInnoi SararatChaiyamoon AradaArun SupatchareeTangsrisakda NareelakChaimontri ChadapornKamollerd TherachonTeerapatpaisan SineenadNualkaew NatsajeeWu Alexander T HIamsaard Sitthichai - Dehydroepiandrosterone (DHEA) plays a crucial role in cardiovascular physiology, while decreased plasma level of DHEA is linked to hypertension and other disorders. Curcuma longa is a globally recognized Indian medicinal plant with cardioprotective potential, but its role in DHEA restoration has not been studied yet. The present study aimed to determine whether a curcuminoid-enriched extract of Curcuma longa (CEECL) can restore serum DHEA levels and modulate DHEA biosynthetic pathways in hypertensive rodent models. L-NAME-induced Hypertension in Wistar rats and Spontaneous Hypertensive Rats (SHR) models were used to assess the effect of CEECL (100, 333, and 1000 mg/kg) using ELISA to estimate the level of circulating DHEA in serum, RT-PCR and immunohistochemistry in quantifying the expression profile of genes and of enzymes associated with DHEA biosynthesis and LC-MS for quantification of DHEA precursors and metabolites. The safety profile of CEECL was evaluated in Swiss albino mice. The study revealed a significant decline in serum DHEA levels in hypertensive conditions, and CEECL treatment restored circulating DHEA levels, improving systolic, diastolic, and mean arterial pressure in both models. Hepatic expression of key enzymes, such as CYP11A1, CYP17A1, and HSD17B1, was normalized after CEECL treatment, including the restoration of DHEA precursor levels. CEECL was well-tolerated in acute and sub-acute toxicity studies in Swiss albino mice. The current study is the first to report the restoration of DHEA biosynthesis and improvement in hemodynamics by curcuminoids-enriched C. longa extract, without the need for exogenous DHEA administration, suggesting therapeutic potential in the management of hypertension. - Source: PubMed
Publication date: 2026/06/25
Mishra DivyaIqbal HinaYadav PankajGupta ShashwatLahane VaibhaviSingh DikshaIshteyaque SharmeenMaurya Anil KumarKumar NarendraTandon SudeepGupta Anil KumarMugale Madhav NilakanthYadav Akhilesh KumarPal AnirbanShanker KarunaNegi Arvind SinghChanda Debabrata - The cytochrome P450 side-chain cleavage enzyme (P450scc) encoded by the CYP11A1 gene regulates the first and rate-limiting step of steroidogenesis. c.1351C>T (p.R451W) is the most commonly identified pathogenic variant in the CYP11A1 gene, and is associated with a mild P450scc deficiency. Long-term follow-up data of affected individuals are insufficient. - Source: PubMed
Publication date: 2026/06/24
Cayir AtillaDemirbilek HuseyinKurt IlknurTurkyilmaz AyberkKoca Serkan BilgeOzbek Mehmet NuriKaraoglan MuratEmeksiz Hamdi CihanDundar IsmailDisci EsraDonmez Ayse SenaCatlı GonulDundar Bumin NAlbayrak SerpilHepokur Merve NurOzden AyseCetinkaya SemraGuran Tulay - Atrazine (ATZ), a frequently employed herbicide, is classified as one of the environmental pollutants that play a pivotal role in progression of male infertility. L-carnitine (LC) and quercetin (QT) possess antioxidant properties, rendering them viable additional treatments for male infertility. Additionally, specialized drug delivery systems, such as niosomes, enhance the distribution of hydrophilic pharmaceuticals. This study aimed to investigate the ameliorative potential of LC and QT, administered in conventional and niosomal formulations, against ATZ-induced testicular dysfunction in adult male albino rats. Thirty rats were randomly assigned to six experimental groups: control, ATZ, ATZ + LC, ATZ + LC-loaded niosomes (LCLN), ATZ + QT, and ATZ + QT-loaded niosomes (QTLN). Treatments were administered orally for 56 consecutive days. Biochemical analyses, sperm evaluations, gene expression assessments, and histopathological measures were conducted. ATZ exposure significantly decreased absolute and relative seminal vesicle weights, impaired sperm motility, viability, morphology and count, and reduced circulating testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) concentrations. Moreover, ATZ markedly elevated malondialdehyde levels, suppressed the activities of endogenous antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), and downregulated the transcription of key steroidogenic genes (HSD3B, StAR and CYP11A1). Histopathological assessment further revealed pronounced degenerative changes in the testes, epididymis, seminal vesicles, and prostate. Co-administration of LC or QT, particularly in niosomal formulations, significantly attenuated these deleterious effects. They restored sperm quality, re-established redox homeostasis, normalized steroidogenic gene expression, and preserved the structural integrity of reproductive tissues. In conclusion, niosomal formulations of LC and QT confer superior protective efficacy against ATZ-induced testicular toxicity compared to their conventional counterparts, underscoring their therapeutic potential as targeted interventions against environmental toxicants. - Source: PubMed
Publication date: 2026/06/22
Azmi Omniya EAbdel-Wahab AhmedAbdel-Rahman Mootaz A MGamal AmrIbrahim Marwa AAhmed Osama MohamedAbdel-Razik Abdel-Razik HAli SafwatEl-Gendy A A M