Ask about this productRelated genes to: KLRF1 Blocking Peptide
- Gene:
- KLRF1 NIH gene
- Name:
- killer cell lectin like receptor F1
- Previous symbol:
- -
- Synonyms:
- CLEC5C, NKp80
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-20
- Date modifiied:
- 2016-01-14
Related products to: KLRF1 Blocking Peptide
Related articles to: KLRF1 Blocking Peptide
- The human immune system undergoes dynamic remodeling from infancy through old age. We profiled PBMCs from 167 healthy individuals (ages 2 months to 105 years): infants (n = 36), children (n = 26), adolescents (n = 20), young adults (n = 24), middle‑aged (n = 16), older adults (n = 33) and oldest old (n = 12) using scRNA‑seq and snATAC‑seq (n = 23). MAIT and γδ T cells showed a "rise and fall" pattern, rising in childhood, peaking in young adulthood, and declining with age. Conventional CD8⁺ T cells were most profoundly altered with age, with decreasing naïve and increasing GZMK⁺ and TEMRA cells. The oldest old had increased TEMRA, adaptive NK, and KLRF1⁺ γδ T cells. Infants showed increased CD16⁺ monocytes and pDCs, constitutive interferon‑stimulated gene expression, and expanded SOX4⁺ naïve T cells. Inflammatory and stress‑response pathways increased with age, while interferon pathways declined. This map provides insights into human immune system dynamics across the human lifespan, emphasizing unique features of the infant immune system. - Source: PubMed
Publication date: 2026/06/15
Nehar-Belaid DjamelThibodeau AsaEroglu AlperMarches RaduEryilmaz GirayGrabauskas TitasTrinity LukeUnutmaz DeryaVerschoor Chris PGu JinghuaBalaji UthraMejías AsunciónPascual VirginiaKuchel George ARamilo OctavioBanchereau Jacques FUcar Duygu - Antiviral treatment for chronic HBV infection in the "high-replicative low-inflammatory" phase has not been widely recommended. This study aimed to evaluate the safety and efficacy of antiviral therapy in this patient population and analyze peripheral immunological characteristics in relation to treatment response. In this randomized controlled trial, HBeAg-positive patients with normal ALT and elevated HBV DNA were randomly allocated 1:1 to receive TAF 25 mg/day or observation. The primary endpoint was the decline from baseline in HBsAg at Week 48. Secondary endpoints included HBV DNA response rates and the magnitude of HBV DNA reduction. The treatment group was further divided into virological response (VR) and low-level viremia (LLV) subgroups based on HBV DNA response at Week 48. PBMCs from VR (n = 3) and LLV (n = 3) patients underwent scRNA-seq for comparative immunological analysis. A total of 59 patients were allocated to the treatment (n = 30) and control (n = 29) groups. No serious adverse events occurred, except for one control patient who developed an ALT flare and required antiviral initiation. At Week 48, the treatment group demonstrated significantly greater reductions in HBsAg (0.19 vs. 0 log10 IU/mL, p = 0.005) and HBV DNA (6.32 vs. 0.19 log10 IU/mL, p < 0.001) compared to controls. In the treatment group, 20% achieved HBV DNA < 20 IU/mL and 3.3% achieved HBeAg seroconversion, while none occurred in the untreated patients. PBMCs scRNA-seq revealed dominant distributions of NK_FCER1G, NK_KLRF1, NK_XCL1, and NKT_FCGR3A subclusters in the VR group, with upregulated expression of genes such as SLC27A4 and PTMA. Taken together, our findings revealed that TAF demonstrates favorable safety and antiviral efficacy in patients with high-replicative, low-inflammatory HBV infection during the 48-week follow-up period, although complete virological suppression rates remain suboptimal. NK-mediated mechanisms may contribute to antiviral success. Trial Registration: The trial was registered on ClinicalTrials.gov (NCT04231565). - Source: PubMed
Luo QiuminXu RuixuanZhang YeqiongXu WenxiongLi XiangyongLai JingLi JianguoZheng XingrongDeng HongChen LubiaoZhu XiangXie ChanPeng Liang - Lung adenocarcinoma (LUAD) is associated with a poor prognosis. Manganese metabolism plays a critical role in antitumor immunity. The prognostic significance of manganese metabolism-related genes (MRGs) in LUAD remains unclear. - Source: PubMed
Publication date: 2026/03/11
Li HongliangWei ShuzhenLi WeiSun JunxiaWang Yi - Memory-like or precursor exhausted (Tpex) CD8 T cells are a critical reservoir in chronic infections and cancer, yet the signals sustaining their cytokine production remain unclear. Here, we identify KLRF1 as part of a CD4-CD8 communication axis that supports cytokine production in late-differentiated human CD8 T cells. KLRF1 is upregulated in late-differentiated CD8 T cells, and neutralizing KLRF1 reduces TNF and IFN-γ production. Differentiated CD4 T cells express the KLRF1 ligand AICL, and in co-culture only AICL - not AICL⁻ - CD4 T cells enhance cytokine output in CD8 T cells. Using spatial proteomics of lung adenocarcinoma and adjacent tissue, we found that CD4 AICL and CD8 KLRF1 T cells are enriched and spatially interacting in non-tumor regions, whereas both populations are reduced within tumor tissue. Single-cell RNA-seq of tissue samples and scRNA/ATAC analyses of circulating immune cells further showed that CD8KLRF1 T cells display a Tpex-like transcriptional and chromatin-accessibility profile. Together, these data identify the AICL-KLRF1 axis as a CD4-CD8 communication pathway that supports cytokine competence in late-differentiated CD8 T cells. - Source: PubMed
Publication date: 2026/03/18
Barone MatthiasPeidli StefanNeuschulz AnikaRiesterer KarlaIwert ChristinaJunquera LaiaSai SomeshBolaji OlufemiBakoueva DianaAppelt ChristineObermayer BenediktKlinger BertramTrinks AlexandraSieber AnjaBlüthgen NilsSawitzki Birgit - Black Americans face a high burden of cardiovascular disease (CVD), with more than 60% of Black adult women affected. However, sex-specific molecular mechanisms underlying poor cardiovascular health (CVH) in this population remain largely unknown. In this study, we examined sex-specific transcriptomics signatures associated with CVH among Black adult men and women. - Source: PubMed
Publication date: 2026/01/19
Blankson Harriet NaDelmer CeciliaVerma RashiGuven EmineRooney KimberlyPearson AndreaBaltrus PeterQuyumi Arshed APemu PriscillaJordan I KingHerman TaylorMeller RobertSearles Charles D