Ask about this productRelated genes to: GJA4 Blocking Peptide
- Gene:
- GJA4 NIH gene
- Name:
- gap junction protein alpha 4
- Previous symbol:
- -
- Synonyms:
- CX37
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-11
- Date modifiied:
- 2016-10-05
Related products to: GJA4 Blocking Peptide
Related articles to: GJA4 Blocking Peptide
- The increasing demand for sustainable and energy-dense feed in poultry nutrition has prompted the exploration of alternative dietary fat sources. The objective of this study was to evaluate how three fat sources, including black soldier fly oil (BSFO), soybean oil (SBO), and tallow (TA), with circular economy relevance, differed in their effects on laying hens' performance, egg and eggshell quality, reproductive hormones, inflammatory markers, and oviductal connexin expression. A 12-week trial was conducted with 288 Hy-Line Brown layers aged 24 weeks allocated to six treatments, six replicates, and eight birds per replicate in a completely randomised design. The trial was categorised into three phases (26-29 weeks, 30-33 weeks, and 34-37 weeks), subjected to six dietary treatments as diet+2% BSFO (BSF2), diet+4% BSFO (BSF4), diet+2% SBO (SOY2), diet+4% SBO (SOY4), diet+2% TA (TA2), and diet+4% TA (TA4). Fat source significantly influenced laying performance, egg quality, inflammatory status, and gene expression, whereas inclusion level and interaction showed no significant effect. Overall, the findings show that hens fed the SBO treatments had higher (P = 0.015, P = 0.009) hen-day egg production during 30-33 weeks, and 34-37 weeks, comparable to BSFO treatments and TA2, which outperformed TA4. Egg mass was higher (P = 0.030) in the SBO treatments, comparable to BSFO, during 34-37 weeks. The Haugh unit was higher (P = 0.016) in the BSFO treatments, which was comparable to SBO during 26-29 weeks. Eggshell thickness was higher (P = 0.043) in the BSFO treatments, comparable to SBO treatments and TA4 during 26-29 weeks. Eggshell hardness was higher (P = 0.045, P = 0.023) in BSFO and SBO treatments during 26-29 weeks, and 34-37 weeks. Moreover, SBO and BSFO treatments significantly reduced serum tumour necrosis factor-alpha levels and increased the expression of gap junction protein alpha 1/connexin 43 (GJA1) and gap junction protein alpha 4/ connexin 39 (GJA4) in the infundibulum. Conversely, TA inclusion was associated with higher pro-inflammatory response and lower connexin expression. The study concludes that BSFO, SBO, and TA, each with circular economy relevance, can support productive performance and physiological health in laying hens. While all three oils are viable energy sources, their biological impacts vary according to each fatty acid profile. - Source: PubMed
Publication date: 2026/06/04
Tajudeen HHosseindoust AMun J YHa S HKim J S - Although follicular development and oocyte competence depend on insulin-like growth factor-1 (IGF-1), its optimal dose and molecular mechanisms during goat maturation (IVM) remain unclear. - Source: PubMed
Publication date: 2026/05/29
Widjiati WidjiatiLuqman Epy MuhammadDarsini NinikAulanni'am Aulanni'amHendrawan Viski FitriKurniawati Devia YoanitaJaafar Wan Nor Fitri Bin Wan - We examined gene expression profiles in abdominal aortic aneurysm (AAA) lesions . normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). - Source: PubMed
Lu SongLi Li PingWhite John VZhang XiaoyingNwaneshiudu IfeyinwaNwaneshiudu AdaobiNtaoula NectariaGaughan JohnMonos Dimitri SLin Wan-LuSolomides Charalambos COleszak Emilia LPlatsoucas Chris D - Colorectal cancer (CRC) shows strong heterogeneity in tumor microenvironment (TME) dynamics, but the mechanisms that shape epithelial-stromal crosstalk are still unclear. Here we focus on A-kinase anchor protein 12 (AKAP12) and Leiomodin 1 (LMOD1) and test a compartment-dependent model in which this program aligns with tight-junction features in epithelium but with a fibrotic, immune-suppressive program in stroma. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) were employed to profile gene expression patterns in CRC tissues. Immunohistochemistry (IHC) and multiplex immunofluorescence (mIF) validated protein expression and localization. Cell-cell communication analysis and trajectory inference were used to dissect spatial interaction networks. Functional experiments were employed to validate the role of the AKAP12-LMOD1 axis in CAFs in regulating ECM remodeling and antitumor immunity. AKAP12-LMOD1 exhibited a compartment-dependent pattern in CRC. In ACTA2⁻ epithelial regions, the epithelial AKAP12-LMOD1 signal was lower in tumors than in matched normal epithelium and showed a positive association with the tight-junction marker CLDN1. In ACTA2⁺ stromal regions, AKAP12-LMOD1 was enriched, positively associated with the gap-junction marker GJA4, and higher in tumor stroma than matched normal stroma. In a CAF-macrophage non-contact co-culture model, AKAP12 overexpression supported CAF activation and collagen deposition, and shifted macrophages toward an M2-like phenotype; LMOD1 knockdown or SB-431542 partially reversed these effects. Stromal AKAP12-LMOD1-enriched regions also aligned with fibrosis- and M2-related features, and these stromal patterns were prominent in mucinous carcinoma. This study defines AKAP12-LMOD1 as a compartment-dependent stromal program in CRC that links ACTA2⁺ stroma to gap-junction features, fibrosis, and M2-like macrophage polarization, while showing a distinct epithelial association with tight-junction features. These findings support a stroma-centered working model for AKAP12-LMOD1 in CRC microenvironmental heterogeneity and suggest that stromal modulation of this program, together with targeting fibrosis and M2-like immune features, may be explored as hypothesis-level, subtype-oriented therapeutic directions in stroma-rich CRC. - Source: PubMed
Publication date: 2026/04/20
Ye Qian-WenLiu Yuan-JieXu GuoChen Yu-GenLi Jie-Pin - Breast cancer-related lymphedema (BCRL) remains a major chronic complication following axillary lymph node dissection (ALND), particularly in regions where locally advanced breast cancer is prevalent. While several clinical factors have been identified, the role of genetic predisposition in BCRL development remains underexplored. This study aimed to identify genetic and clinical factors associated with the development of BCRL, focusing on the Gap Junction Protein Alpha-4 (GJA4) rs705193 mutation as a potential biomarker. - Source: PubMed
Publication date: 2026/02/17
Putri Rizky IfandrianiSutandyo NoorwatiSiregar Nurjati ChairaniWanandi Septelia InawatiHarimurti KuntjoroHernowo Bethy SBrahma BayuPerdana Adhitya BayuWidiasti InnasSari Erin KurniaPanigoro Sonar Soni