Ask about this productRelated genes to: IFIH1 Blocking Peptide
- Gene:
- IFIH1 NIH gene
- Name:
- interferon induced with helicase C domain 1
- Previous symbol:
- -
- Synonyms:
- MDA-5, Hlcd, MDA5, IDDM19
- Chromosome:
- 2q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-25
- Date modifiied:
- 2019-04-23
Related products to: IFIH1 Blocking Peptide
Related articles to: IFIH1 Blocking Peptide
- Childhood-onset systemic lupus erythematosus (cSLE) is associated with significant morbidity and mortality. While numerous variants have been associated with adult-onset SLE, limited data exist on genetic variation within cSLE. We aimed to investigate genetic factors of early-onset cSLE, defined as onset of cSLE prior to age 10. - Source: PubMed
Publication date: 2026/06/23
Nelson MeghanMurthy ShantaMaddipatla SushmaShenoy SreekalaPonder LoriChandrakasan ShanmuganathanKugathasan SubraCutler DavePrahalad Sampath - Adults with unexplained neurologic presentations often undergo extensive evaluations without timely diagnosis. Evidence supporting the clinical utility of rapid whole-genome sequencing (rWGS) in hospitalized adult populations remains limited. We evaluated the diagnostic yield of rWGS in adults hospitalized for unexplained neurologic manifestations and assessed clinical predictors of a phenotype-concordant genetic diagnosis. - Source: PubMed
Publication date: 2026/06/16
Amanat ManToledano MichelSchimmenti Lisa APichurin Pavel NLanpher Brendan CDeyle David RTan Queenie K GIverson GabrielleCera AlannaGavrilova RalitzaDhamija Radhika - To identify the clinical phenotype and prognostic determinants in patients with anti-MDA5 antibody-positive dermatomyositis (MDA5+DM) with spontaneous pneumomediastinum (SPM). - Source: PubMed
Publication date: 2026/05/29
Wang XiaoyingZhang YushengLiu LijunLi WeiLiu XiaojunWang Yan - SARS-CoV-2 infection causes an innate immune response that is activated through pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs). Endosomal TLR7/8 detects viral ssRNA, while TLR3 also recognizes dsRNA formed during viral replication. Both RIG-I and MDA5 recognize SARS-CoV-2 RNA in the cytoplasm of infected cells. PRR pathways recruit essential downstream adapter proteins to induce type I interferons (IFNs) and inflammatory cytokines. While genetic variations in host may influence SARS-CoV-2 infection, immune response, and COVID-19 severity, their specific role in triggering these processes remains unclear. This study analyzes the frequency of specific polymorphisms within genes in COVID-19 patients to evaluate their impact on disease severity. - Source: PubMed
Publication date: 2026/05/28
Paradowska EdytaKania Katarzyna DJarych DariuszMikulski DamianJabłonowska ElżbietaHaręża Daria AWójcik-Cichy Kamila - Erythroderma in the pediatric population is an uncommon yet challenging condition. The etiologies encompass a wide variety of illnesses, including seborrheic dermatitis, infections, inborn errors of immunity, ichthyosiform disorders and metabolic abnormalities. Hyper-immunoglobulin E syndrome (HIES) occurs due to various known genetic variants, e.g., STAT3 (signal transducer and activator of transcription-3), IL6R (Interleukin-6 receptor) deficiency and others, with an extensive list of features including erythroderma in childhood. Our case describes association of a possible novel mutation in IFIH1 (interferon-induced with helicase C domain 1) gene with HIES, which may aid in deciphering the complex nature of this disorder. - Source: PubMed
Publication date: 2026/06/14
Belgaumkar VasudhaBhatia SukhdeepTolat SunilPradhan Shekhar