Ask about this productRelated genes to: TM2D2 Blocking Peptide
- Gene:
- TM2D2 NIH gene
- Name:
- TM2 domain containing 2
- Previous symbol:
- -
- Synonyms:
- BLP1
- Chromosome:
- 8p11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-19
- Date modifiied:
- 2017-11-23
Related products to: TM2D2 Blocking Peptide
Related articles to: TM2D2 Blocking Peptide
- Plastic phenotypes are important biological adaptations, yet their evolution and genomic basis remains insufficiently unexplored. This study examines the origin of an inducible defensive structure, the helmet, that emerged during evolution of a novel morphotype in the freshwater microcrustacean This specific morphotype exhibits a consitutively expressed pointed head shape as a juvenile and forms conspicuous retrocurved helmets in response to infochemicals of the predatory cladoceran Our genomic analyses, focusing on single-nucleotide and genome structural variation, indicate monophyletic origin of this morphotype, which apparently emerged following a pond-to-lake habitat shift. The ancestral round-headed morphotype of lives in pond habitats without and apparently lacks ability to form large inducible helmets. The divergence of the two morphotypes is characterized by signals of positive selection and extensive chromosome structural changes. A signal of hard selective sweep is particularly strong in the tightly linked and genes, both involved in morphogenesis, but with a contrasting level of divergence between morphotypes. differs in coding regions and amino acid sequences, indicating protein-level changes; differences primarily involve regulatory regions, as confirmed by different level of expression of this gene between morphotypes despite shared protein sequences. knockout mutants for or , generated from a helmet-forming clone using CRISPR-Cas9, exhibit much reduced plastic formation of the helmet, demonstrating the polygenic control of this adaptive trait and large effect sizes of the respective genes. Our study characterizes the evolutionary and genetic basis of a classic example of an adaptive plastic trait. - Source: PubMed
Publication date: 2026/07/16
Deng ZhixiongXu SenLi DengqingYu GuoNeupane SwatantraWang LiBlair DavidHu WeiPetrusek AdamYin Mingbo