Ask about this productRelated genes to: TNFSF12 Blocking Peptide
- Gene:
- TNFSF12 NIH gene
- Name:
- TNF superfamily member 12
- Previous symbol:
- -
- Synonyms:
- TWEAK, DR3LG, APO3L
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2019-04-23
Related products to: TNFSF12 Blocking Peptide
Related articles to: TNFSF12 Blocking Peptide
- The neurotoxicity mechanisms of tetrachloro-1,4-benzoquinone(TCBQ) remain poorly understood. This study integrated computational simulations validation to elucidate TCBQ-induced neurotoxicity. - Source: PubMed
Publication date: 2026/06/09
Rong ChunshuWei ZhenXie DongeWang QingyuanRen HaoxuWang XuZhao Dexi - Preeclampsia (PE) is a complex pregnancy disorder associated with early placental hypoxia, oxidative stress, and impaired angiogenic signaling. Melatonin and soluble tumor necrosis factor like weak inducer of apoptosis (sTWEAK) contribute to antioxidant and vascular pathways, whereas their receptors, melatonin receptor 1A (MTNR1A), melatonin receptor 1B (MTNR1B), and fibroblast growth factor-inducible 14 (Fn14), may be subject to epigenetic regulation. This study assessed serum melatonin and sTWEAK levels in parallel with promoter methylation of MTNR1A, MTNR1B, and Fn14 in early gestation. - Source: PubMed
Publication date: 2026/06/08
Shahid Sana KashifFatima Syeda SadiaFarhat SabahKhan Shah JabeenIqbal Mehir Un Nisa - Immune dysregulation plays a critical role in idiopathic pulmonary fibrosis (IPF), but the mechanisms underlying this dysregulation remain unclear. - Source: PubMed
Publication date: 2026/06/03
Zhao JiaxingLiu ZenghuiKuang LuDong AijiaGong HeyueYin HuayuWu ShaoguoLiu DabinLiu XuehuiLiu ShuyanWu Limei - The global incidence of squamous cell carcinoma (SCC) is on the rise. Previous studies have confirmed that the TWEAK/cIAP1/NF-κB axis plays a crucial role in SCC progression. Acteoside (ACT), a phenylethanoid glycoside with established antitumor properties, has not been fully elucidated regarding its specific effects and underlying mechanisms in SCC. - Source: PubMed
Publication date: 2026/05/28
Zhang ZijianDong QinyiLi SiyingShan JixuanZhang HanWang XinmanBai JiahaoFu XiaoyiHan HuiyanShi LeiJiang XiaokeZheng KailiLiang Lili - TWEAK is a multifunctional cytokine that exists in both membrane-bound and soluble forms. TWEAK interacts with its sole receptor, Fn14, leading to the activation of various downstream signaling pathways, including MAPK, NF-κB, JAK/STAT, Smad, etc., thereby regulating cell fate. The TWEAK/Fn14 signaling cascade is a unique pathway that is involved in the development mechanisms of different diseases targeting cardiovascular, pulmonary, dermatological, cancer, etc. Activation of the signaling pathway results in cytokines and chemokines production, which exert their role by communicating with neighboring cells, promoting cell differentiation, proliferation, angiogenesis, apoptosis, autophagy, etc. However, the function and process of the TWEAK/Fn14 signaling pathway in various diseases have not been completely understood. Furthermore, clinical translation of TWEAK/Fn-14-mediated targeted therapies faces several challenges, including a lack of specific biomarkers, limited clinical evidence, and disease-specific heterogeneity. In this review, we have systematically outlined the current knowledge about the structural, functional, and pharmacological functions of the TWEAK/Fn14 signaling pathway. We have outlined how further experimental research is necessary to understand the molecular mechanisms associated with the pathway. Additionally, we also highlight the emerging potential of small druggable molecules targeting the TWEAK/Fn14 signaling cascade, emphasizing future directions for the management of various diseases. - Source: PubMed
Publication date: 2026/05/23
Verma PiyushTuli Hardeep SinghPaudel Keshav RajGupta Madhu