Ask about this productRelated genes to: NR2F2 Blocking Peptide
- Gene:
- NR2F2 NIH gene
- Name:
- nuclear receptor subfamily 2 group F member 2
- Previous symbol:
- ARP1, TFCOUP2
- Synonyms:
- COUP-TFII, COUPTFB, SVP40, NF-E3, COUPTF2
- Chromosome:
- 15q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-03-21
- Date modifiied:
- 2018-02-14
Related products to: NR2F2 Blocking Peptide
Related articles to: NR2F2 Blocking Peptide
- The present study was devoted to the analysis of associations of single-nucleotide polymorphisms (SNPs) of genes affecting the concentration of circulating sex hormone-binding globulin (SHBG) (information was obtained from genome-wide association studies [GWAS]) with the development of preeclampsia (PE). This retrospective study was performed with a case-control design using a sample of 891 pregnant women, including women with PE [n = 431] and without PE (control) [n = 460] who underwent an experimental genetic study of 11 SNPs (rs17496332 [], rs780093 [], rs10454142 [], rs3779195 [], rs440837 [], rs7910927 [], rs4149056 [], rs8023580 [], rs12150660 [], rs727428 [], and rs1641549 []) that had previously shown a connection with the concentration of circulating SHBG in GWAS. As a result of the associative analysis, it was revealed that the polymorphism rs10454142 was associated with PE risk [the data were obtained within the framework of a recessive genetic model]: the CC genotype of this SNP had an impact risk value for PE (OR: 1.73; 95%CI: 1.16-2.66; : 0.014). The PE-associated variant rs10454142 and its proxy SNPs demonstrate potential pronounced functionality both in the liver (the main organ of SHBG formation) and organs/cell cultures targeted for PE (trophoblast, amnion, placenta, and uterus), thereby affecting the regulation of gene transcription, nucleic acid metabolism, and embryo development. In conclusion, this exploratory study was the first to show the risk effect of the SHBG-related genetic variant in the formation of PE. - Source: PubMed
Publication date: 2026/09/20
Churnosova MariaReshetnikov EvgenySorokina InnaAristova InnaTsoy KirillVoronin MikhailAbramova MariaPolonikov AlexeySolodilova MariaChurnosov MikhailPonomarenko Irina - To develop and characterize a xeno-free, two-dimensional (2D) differentiation protocol for directing human induced pluripotent stem cells (hIPSCs) toward photoreceptor (PhR)-like cells, using a live-reporter system and transcriptomic analysis to evaluate lineage fidelity and maturation compared to the three-dimensional (3D) culture paradigm. - Source: PubMed
Publication date: 2026/06/22
Beaver DaviniaCioanca Adrian CBarnett Nigel L - To identify key genes associated with keloid through integrative analysis of multiple transcriptomic datasets, and to explore their potential regulatory roles in disease development with experimental validation. - Source: PubMed
Publication date: 2026/09/17
Yang LingyiMo WenshenCao WendiMi LinWu Xiaowei - Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that mediate the cellular response to hormones, vitamins, and dietary lipids, thus orchestrating numerous physiological processes and influencing multiple disease states. Within this superfamily, NR2Fs, also known as Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF), are a family of nuclear orphan receptors, due to the lack of known endogenous ligands. Among them, NR2F2 transcription factor activities involve regulation of cell differentiation during organogenesis, maintenance of adult tissue homeostasis, and tumorigenesis. To date, only the CIA compounds have been identified as inhibitors of NR2F2 driven transcriptional activity in prostate cancer cell lines, with the IC50 of CIA1 falling in the lower μM range. - Source: PubMed
Publication date: 2026/08/25
Culletta GiuliaRoomi Muhammad SohaibCaricasulo Maria AzzurraZanetti AdrianaTerao MinekoParoni GabrielaGarattini EnricoTutone Marco - : Uterine dysfunction contributes to infertility in PCOS. Jiawei Qi Gong Wan (JQGW) is used to improve endometrial homeostasis, but its mechanism is unclear. This study investigated whether JQGW improves uterine function via gut microbiota and metabolites. : Letrozole-induced PCOS mice received JQGW (low/high dose), metformin, or vehicle for 35 days. Endometrial morphology, receptivity genes, Akt2/NF-κB signaling, gut microbiota (16S rRNA), and serum metabolites (LC-MS) were assessed. : PCOS mice showed reduced endometrial thickness (126.4 ± 10.8 μm vs. 215.6 ± 12.3 μm in controls, < 0.001) and fewer glands (12.6 ± 1.8 vs. 28.4 ± 2.1, < 0.001). JQGW-H increased endometrial thickness (189.3 ± 11.2 μm, < 0.01 vs. PCOS) and gland number (23.1 ± 1.9, < 0.01 vs. PCOS), restored the receptivity markers (, , , and ) toward normal levels, suppressed Akt2/NF-κB activation, and reduced inflammatory cytokines. JQGW shifted the β-diversity structure of the gut microbiota toward the control pattern, with enrichment (LDA > 4). Four metabolites (PA(20:0/16:1(9Z)), 7-methylguanosine, methoxyacetic acid, 8.11-eicosadiynoic acid) showed nominal elevation in PCOS and negative correlations with endometrial thickness (r = -0.73 to -0.89, unadjusted < 0.01), although none survived FDR correction. : JQGW ameliorates PCOS-associated uterine dysfunction, potentially via gut microbiota and metabolite modulation. Future studies should validate causality using fertility-based outcomes and microbiota transplantation. - Source: PubMed
Publication date: 2026/07/24
Zheng RuqunSong JinlongLi JieShen YingyanLiu QiqiShi MengjiaZhuo YuxuanLuo HaoyuLi JingMa HongxiaHu MinWang Chi ChiuLi Juan