Ask about this productRelated genes to: GFRA4 Blocking Peptide
- Gene:
- GFRA4 NIH gene
- Name:
- GDNF family receptor alpha 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-18
- Date modifiied:
- 2016-10-05
Related products to: GFRA4 Blocking Peptide
Related articles to: GFRA4 Blocking Peptide
- Glioblastoma is the most frequent and aggressive primary brain cancer in adults, and the prognosis is poor. The neurotrophic factor glial cell-derived neurotrophic factor (GDNF) and its receptors, which are involved in neuronal development, have in experimental studies been suggested to drive tumorigenic processes in glioblastoma, but the role and expression in glioblastoma in patients is under-investigated. The aim of this study was to investigate the expression of GDNF, GDNF family receptor 1-4 (GFRA1-4), and the downstream REarranged during Transfection (RET) receptor in human glioblastoma tissue by RNA in situ hybridization, immunohistochemistry, and immunofluorescence. Expression was quantified by software-based classifiers. The results showed that GDNF was expressed in approximately 10% of tumor cells. The GFRA1 receptor was widely expressed in tumor cells, often colocalizing with the astrocytic tumor cell marker glial fibrillary acidic protein (GFAP), and in a smaller fraction of tumor cells expressing the stem cell markers oligodendrocyte transcription factor 2 (OLIG2) and SRY-Box Transcription Factor 2 (SOX2). The GFRA2 receptor expression was very limited, whereas expression of GFRA3, GFRA4, and RET, respectively, was almost absent. In conclusion, GDNF and its primary receptor GFRA1 were expressed in patient glioblastoma tissue. Potential clinical value needs further investigation. - Source: PubMed
Publication date: 2025/09/28
Ewald Jesper DupontKnudsen Arnon MøldrupWohlleben HelleChristiansen LoneMichaelsen Signe RegnerAnand AtulKristensen Bjarne Winther - Understanding the genetic basis of high-performance animals is vital for biological insight and breeding. This study aimed to identify genetic factors distinguishing champion gamecocks () from less successful ones, representing the first study to link transcriptomic profiles directly to competitive outcomes. Using RNA sequencing on non-invasive feather samples, we compared gene expression between high-performing (≥80% win rate) and low-performing (≤20% win rate) cohorts. Our analysis identified 441 differentially expressed genes. Notably, the high-performing cocks exhibited the significant upregulation of genes integral to muscle development and repair (e.g., , ) and enhanced neural function (). Conversely, several genes involved in neural development pathways, including and , were significantly downregulated in the high-performing group. These findings suggest that a rooster's competitive success is not determined by a single factor, but by a complex interplay of superior muscular capabilities and uniquely regulated neurological pathways. The identified genes provide a set of potential biomarkers that could inform selective breeding strategies aimed at enhancing performance traits in gamecocks. - Source: PubMed
Publication date: 2025/08/16
Piratae SupawadeeYamtubtim ChanisthaNonsri ThanitapornPoomprasert PanpanitPurisotayo Tarid - Atrial fibrillation (AF) is the most prevalent arrhythmia in the world and can cause serious complications such as stroke or heart failure. Paroxysmal atrial fibrillation (PAF), a subtype of AF, accounts for approximately 25% of AF cases and is estimated to affect approximately 30 million people worldwide. Despite extensive genetic research on AF, the genetic factors involved in PAF in East Asian (EAS) populations remain unidentified. The aim of our study was to identify genetic factors associated with PAF in the Japanese population, contributing to our understanding of the genetic architecture of AF in Japanese populations. We conducted whole-exome sequencing on a cohort of 1176 PAF individuals and 1172 non-PAF control subjects in a Japanese population. We processed the sequencing data in accordance with the best practices outlined in the Genome Analysis Toolkit (GATK) and conducted gene-based association tests under three variant grouping strategies (masks) using the burden test, SKAT, and SKAT-O. We then performed a meta-analysis of the resulting P-values, which revealed that four genes-ZNF785, SMPD3, GFRA4, and LGALS1-were significantly associated with PAF, representing novel findings. These findings provide new insights into PAF pathogenesis and suggest potential biomarkers for early detection. - Source: PubMed
Publication date: 2025/04/17
Tabata KanjiSudo TakeakiNagata YukiIhara KensukeAsada KenKinoshita AtsuhiroTanaka YasuakiYamauchi YasuteruSasaki TakeshiHachiya HitoshiImai YasushiFujita HideoSasano TetsuoFurukawa TetsushiIwata TakanoriTanaka Toshihiro - The main goal of this study was to pinpoint functional candidate genes associated with multiple economically important traits in Nellore cattle. After quality control, 1830 genomic regions sourced from 52 scientific peer-reviewed publications were used in this study. From these, a total of 8569 positional candidate genes were annotated for reproduction, 11,195 for carcass, 5239 for growth, and 3483 for morphological traits, and used in an over-representation analysis. The significant genes (adjusted -values < 0.05) identified in the over-representation analysis underwent prioritization analyses, and enrichment analysis of the prioritized over-represented candidate genes was performed. The prioritized candidate genes were , , , , , and for reproduction; , , , , , , , , , and for the carcass; and for growth traits; and no genes were prioritized for morphological traits. The functional analysis pinpointed the following genes: (plays a crucial role in spindle organization, which is essential in forming a robust mitotic centrosome), (involved in muscle cell differentiation), and (involved in protein deubiquitination, thereby improving growth). The enrichment of the functional candidate genes identified in this study highlights that these genes play an important role in the expression of reproduction, carcass, and growth traits in Nellore cattle. - Source: PubMed
Publication date: 2024/08/27
Ogunbawo Adebisi RMulim Henrique ACampos Gabriel SOliveira Hinayah R - - Source: PubMed
Publication date: 2024/07/30
Gianfrani CarmenDel Pozzo Giovanna