Ask about this productRelated genes to: TEX9 Blocking Peptide
- Gene:
- TEX9 NIH gene
- Name:
- testis expressed 9
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-21
- Date modifiied:
- 2014-11-19
Related products to: TEX9 Blocking Peptide
Related articles to: TEX9 Blocking Peptide
- Defective sperm motility is frequently associated with male infertility. The immotile short-tail sperm (ISTS) defect is a rare condition in which most sperm cells have abnormally short tails, impairing their motility and leading to infertility. Despite its implications, the genetic factors related to the ISTS defect remain largely unclear. In this study, we identify coiled-coil domain-containing 112 (CCDC112) as a critical factor for sperm tail formation. CCDC112 can associate with microtubules and interact with multiple centrosomal proteins, including PCM1, TEX9, and taxilin. Disruption of CCDC112 expression profoundly affects the cellular distribution of PCM1. Interestingly, the knockout of Ccdc112 in mice impacts spermiogenesis, resulting in the ISTS defect and ultimately causing male infertility. Furthermore, quantitative proteomic analysis highlights the essential role of CCDC112 in regulating axonemal microtubule inner proteins. We thus characterize CCDC112 as a microtubule-associated protein and substantiate its genetic link to ISTS-related male infertility. - Source: PubMed
Publication date: 2026/06/25
Li QingchaoZi XiruiLu YueYin HanxiaoLyu QianHan JunhaoShen HuixinMeng XiaoqianNai ShanshanZhou JunZhao HuijieSong Ting - Cilia are microtubule-based organelles essential for motility, sensory signaling and development. In humans, motile cilia facilitate fluid movement, and their dysfunction causes ciliopathies, including infertility. We used RNAi-mediated knockdown of two human spermatid flagellar genes in to assess effects on ciliary function and locomotion. Knockdown of and significantly reduced planarian swim rate by 26.4% and 33.2% respectively and shortened cilia by 37.1% and 38.7% respectively. These findings highlight the critical roles of ROPN1L and TEX9 in cilia function and the use of planarians as a valuable model for studying ciliopathies. . - Source: PubMed
Publication date: 2026/04/16
Pitt RachelGogoi ChayanikaCalnan AngelinaPatnaik LataJohnson Kristen C - Infertility affects around 15% of all couples worldwide and is increasingly linked to variants in genes specifically expressed in the testis. Well-established causes of male infertility include pathogenic variants in the genes TEX11, TEX14, and TEX15, while few studies have recently reported variants in TEX13B, TEX13C, FAM9A (TEX39A), and FAM9B (TEX39B). - Source: PubMed
Publication date: 2023/08/18
Sieper Marie HGaikwad Avinash SFros MarionWeber PhilippDi Persio SaraOud Manon SKliesch SabineNeuhaus NinaStallmeyer BirgitTüttelmann FrankWyrwoll Margot J - In the context of the Human Proteome Project, we built an inventory of 412 functionally unannotated human proteins for which experimental evidence at the protein level exists (uPE1) and which are highly expressed in tissues involved in human male reproduction. We implemented a strategy combining literature mining, bioinformatics tools to collate annotation and experimental information from specific molecular public resources, and efficient visualization tools to put these unknown proteins into their biological context (protein complexes, tissue and subcellular location, expression pattern). The gathered knowledge allowed pinpointing five uPE1 for which a function has recently been proposed and which should be updated in protein knowledge bases. Furthermore, this bioinformatics strategy allowed to build new functional hypotheses for five other uPE1s in link with phenotypic traits that are specific to male reproductive function such as ciliogenesis/flagellum formation in germ cells (CCDC112 and TEX9), chromatin remodeling (C3orf62) and spermatozoon maturation (CCDC183). We also discussed the enigmatic case of MAGEB proteins, a poorly documented cancer/testis antigen subtype. Tools used and computational outputs produced during this study are freely accessible via ProteoRE (http://www.proteore.org), a Galaxy-based instance, for reuse purposes. We propose these five uPE1s should be investigated in priority by expert laboratories and hope that this inventory and shared resources will stimulate the interest of the community of reproductive biology. - Source: PubMed
Publication date: 2020/10/16
Vandenbrouck YvesPineau CharlesLane Lydie - Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant digestive tumors around the world. We previously demonstrated that eIF3b could promote the progression of ESCC. The exact mechanisms underlying these effects remained unknown. - Source: PubMed
Publication date: 2019/09/03
Xu FengkaiZhang ShuLiu ZhongheGu JieLi YinWang LinMao WeiZhu QiaoliangShou HuankaiGe DiLu Chunlai