Ask about this productRelated genes to: LCMT2 Blocking Peptide
- Gene:
- LCMT2 NIH gene
- Name:
- leucine carboxyl methyltransferase 2
- Previous symbol:
- -
- Synonyms:
- KIAA0547, MGC9534, TYW4, PPM2
- Chromosome:
- 15q15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-29
- Date modifiied:
- 2014-11-19
Related products to: LCMT2 Blocking Peptide
Related articles to: LCMT2 Blocking Peptide
- Exposure to racial discrimination is a well-documented risk factor for adverse pregnancy outcomes. It is hypothesized that this association occurs through epigenetic changes. Researchers have identified associations between perceived discrimination and methylation of stress-response genes among racially and ethnically minoritized women. However, findings are limited by small sample sizes and inclusion of women who are several years postpartum. Little is known about the influence of discrimination on DNA methylation among Black women in pregnancy. Therefore, we conducted an epigenome-wide association study of 897 Black pregnant women who participated in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) study to examine associations between experiences of racial discrimination and DNA methylation. Racial discrimination was measured using responses to the Experiences of Discrimination scale (range 0-9) completed in the second trimester of pregnancy. We dichotomized responses into low discrimination (0-2) and high discrimination (≥ 3) categories. Whole blood was collected in the first trimester of pregnancy and used for DNA extraction. We identified 130 CpG sites significantly associated with high levels of racial discrimination. There were 17 genes mapped to the 20 most significant CpG sites. Fourteen of those genes have disease-associated phenotypes including cancer (LCMT2, LINC02753, RARA, HSP90AA1, SMTN, LPCAT1, SPAG4, DAPK1, ZNF500), cardiomyopathy (SMTN), ovarian insufficiency (DMRT3), neurodevelopmental disability (MLPH, CDC123, OGFOD3), and asthma (STAT6). We identified novel associations between racial discrimination and disease-related genes among Black nulliparous pregnant women. Future research should include structural racism measures and study epigenetic pathways between racism and adverse pregnancy and birth outcomes. - Source: PubMed
Publication date: 2026/06/25
Harkins Sarah EHazi Arielle KZhao TingtingReho PaoloWu HaotianSamari GoleenWapner RonaldZhao YihongBarcelona Veronica - Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of kidney cancer. Defects in transfer RNA (tRNA) modification can lead to significantly impaired protein synthesis and misfolding, contributing to various pathologies, including malignancies. The present study aimed to develop a method predict survival outcomes and guide both immunotherapy and chemotherapy in patients with ccRCC. Patient data was collected from The Cancer Genome Atlas and tRNA modification-related genes from the Molecular Signature Database were identified. External validation of the prognostic model was conducted using the GSE29609 dataset from the Gene Expression Omnibus database. Molecular subtypes were determined through univariate Cox analysis of tRNA modification-related genes and the 'ConsensusClusterPlus' package. Multivariate Cox regression and the least absolute shrinkage and selection operator analyses were employed to establish a prognostic profile consisting of six independent prognostic genes: FTSJ1, LCMT2, METTL6, PUS1, TRMO and TRMT5. Higher risk scores and Cluster 2 classification were associated with poorer overall survival and increased expression of human leukocyte antigens and immune checkpoints. The assessment of immune cell infiltration and the tumor microenvironment was conducted using the ESTIMATE, CIBERSORT and single sample Gene Set Enrichment Analysis algorithms, were compared with the molecular subtypes and risk profiles of tRNA modification regulators. Additional analyses included somatic mutation analysis, nomogram construction, chemotherapy response prediction and small molecule drug prediction. Finally, the expression levels of the six identified genes in ccRCC cell lines were validated using reverse transcription-quantitative PCR, which confirmed consistency with the predictions made. The present study introduced a six-gene prognostic signature that may improve prognosis and facilitate personalized treatment strategies for patients with ccRCC in the future, thereby potentially enhancing individualized patient management. - Source: PubMed
Publication date: 2025/05/22
Zhu XuShen ChengZhang WeiJi YuanfeiXu SiyangZheng BingChen Zhan - Therapeutic approaches for acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS) differ due to distinct diagnostic criteria and treatment strengths. However, reliable biomarkers to differentiate AML from MDS are needed. This study investigated transfer RNA (tRNA) modifications, particularly hydroxy-wybutosine (OHyW), in the transition from MDS to AML. We found a significant decrease in OHyW and its biosynthetic enzyme leucine carboxyl methyltransferase 2 (LCMT2, alias symbol is TYW4) levels in AML compared to MDS. Mass spectrometric analysis revealed distinct tRNA modification patterns, with AML showing decreased OHyW and increased precursor levels, indicating a disrupted biosynthetic pathway. Lower LCMT2 expression correlated with reduced drug sensitivity and limited differentiation potential in AML cell lines. The results highlight the pivotal role of tRNA modifications in the progression from MDS to AML and suggest that targeting LCMT2 may enhance therapeutic outcomes in AML. By understanding these molecular mechanisms, we can develop new diagnostic markers and therapeutic strategies, potentially transforming the clinical management of AML and improving patient outcomes. - Source: PubMed
Publication date: 2024/11/10
Chen XuGong Rui-ZeMo Liu-YingCheng Ya-TingMa YuQi Yi-TaoYan Tong-MengJiang Zhi-Hong - Despite strong evidence of heritability, few studies have attempted to unveil the genetic underpinnings of testosterone levels. - Source: PubMed
Publication date: 2021/05/25
Fantus Richard JNa RongWei JunShi ZhuqingResurreccion W KyleHalpern Joshua AFranco OmarHayward Simon WIsaacs William BZheng S LillyXu JianfengHelfand Brian T - l-arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to stroke pathology in both human and mouse studies. However, a comprehensive understanding of the underlying molecular mechanism is lacking. To investigate transcriptional changes in cerebral AGAT metabolism, we applied a transcriptome analysis in brains of wild-type (WT) mice compared to untreated AGAT-deficient (AGAT) mice and AGAT mice with creatine or hArg supplementation. We identified significantly regulated genes between AGAT and WT mice in two independent cohorts of mice which can be linked to amino acid metabolism (, ), creatine metabolism (), cerebral myelination () and neuronal excitability (). While and showed regulation by hArg supplementation, and were creatine dependent. Additional regulated genes such as and need further evaluation of their influence on cerebral function. Experimental stroke models showed a significant regulation of and . Together, these results reveal that AGAT deficiency, hArg and creatine regulate gene expression in the brain, which may be critical in stroke pathology. - Source: PubMed
Publication date: 2020/03/09
Jensen MäritMüller ChristianSchwedhelm EdzardArunachalam PriyadharshiniGelderblom MathiasMagnus TimGerloff ChristianZeller TanjaChoe Chi-Un