Ask about this productRelated genes to: RBMS3 Blocking Peptide
- Gene:
- RBMS3 NIH gene
- Name:
- RNA binding motif single stranded interacting protein 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-25
- Date modifiied:
- 2016-10-05
Related products to: RBMS3 Blocking Peptide
Related articles to: RBMS3 Blocking Peptide
- Cervical cancer (CC) is a prevalent malignancy in women. RNA-binding motif single-stranded interacting protein 3 (RBMS3) acts as a tumor suppressor in many cancer types, but its role and underlying regulatory mechanisms in CC remain unclear. - Source: PubMed
Huang HuapingLi PingZhu LixiaWu YaweiLiu QinZhang Hong - Colon adenocarcinoma (COAD) shows marked clinical heterogeneity, and robust biomarkers with mechanistic relevance are still needed for prognostic stratification. has been implicated in tumor biology, but its pan-cancer significance, prognostic value in COAD, and regulatory mechanisms remain insufficiently defined. - Source: PubMed
Publication date: 2026/06/24
Sun HaiyingMa ChaoJia WeiXue MeiZhang MengqiaoShuai JunfangWang JingSun Fanyue - Prostate cancer remains a major global health concern for men, with hypoxia and immune escape being key drivers of tumor progression; however, no reliable diagnostic signature integrating both processes has been established for clinical use. In this study, we integrated RNA sequencing and microarray data from The Cancer Genome Atlas (TCGA)-PRAD, Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO) datasets to identify hypoxia and immune escape-related genes (HIERGs). Through differential expression analysis, functional enrichment, and machine learning algorithms including Random Forest, SVM-RFE, and LASSO regression, we constructed a robust six-gene diagnostic signature comprising , , , , , and . The model demonstrated high diagnostic accuracy, with area under the curve (AUC) values exceeding 0.9 across all validation cohorts, as confirmed by calibration curves, decision curve analysis, and receiver operating characteristic curves. Functional analysis revealed significant enrichment in translation-related pathways and smooth muscle contraction, and the RiskScore was significantly associated with altered immune cell infiltration in the tumor microenvironment. Regulatory network analysis further uncovered potential upstream regulators and therapeutic agents targeting the key genes. In conclusion, we developed and validated a hypoxia and immune escape-related gene signature with robust diagnostic performance for prostate cancer. Exploratory grouping by the model-derived RiskScore revealed differences in pathway and immune infiltration patterns, suggesting an association between the signature and intratumoral molecular heterogeneity. These exploratory findings primarily serve to characterize the biological features related to the model and provide supplementary clues for understanding molecular alterations in prostate cancer; they should be interpreted with caution. - Source: PubMed
Publication date: 2026/05/18
Gan HexiaJiang JianaYang JiebinShen FengLu WeihongLai PengChen LingyuXu ZhibingZhang JianpingGuo JianmingChao Fan - This study aims to investigate the role of AU-rich element RNA-binding factor 1 (AUF1) in regulating inflammatory responses and senescence processes within auditory hair cells. - Source: PubMed
Publication date: 2026/05/26
Li LihuaXiao YunLiu XingruiHe JinyingWu WenjingCai DianChen Xubo - - Source: PubMed
Publication date: 2026/05/15
Wang YixiaoSun HuiHou XiaoyaXing WenluXu ZhengguoZhang QingsongYang Bo