Ask about this productRelated genes to: Shc3 Blocking Peptide
- Gene:
- SHC3 NIH gene
- Name:
- SHC adaptor protein 3
- Previous symbol:
- -
- Synonyms:
- N-Shc, NSHC, SHCC
- Chromosome:
- 9q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-12
- Date modifiied:
- 2016-05-16
Related products to: Shc3 Blocking Peptide
Related articles to: Shc3 Blocking Peptide
- ALK and ROS1 fusions are key drivers of infant-type hemispheric gliomas (IHG). With diverse gene partners, the impact of ALK and ROS1 oncoprotein heterogeneity on glioma biology remains unknown. We developed an integrative phospho-proteomic and transcriptomic approach to discover biological functions regulated by five IHG-associated fusions: CCDC88A::ALK, PPP1CB::ALK, GOPC::ROS1, CLIP1::ROS1, and KIF21A::ROS1. Here, we report fusion-specific oncogenic functions conferred by the 5' gene partner, including increased cell motility driven by microtubule-interacting fusions CCDC88A::ALK and CLIP1::ROS1. All studied fusions converge on STAT3 activation. Using affinity purification mass spectrometry, we identified SHP2 in direct interaction with all three ROS1 oncoproteins but with none of the ALK oncoproteins, which in turn interact with SHC1/SHC3. ROS1 fusions phosphorylate SHP2 to a greater extent than ALK fusions, and analyses of downstream pathways suggest MAPK-independent, non-canonical SHP2-driven functions. Our findings reveal both common and fusion-specific dependencies, offering opportunities to optimize therapeutic strategies for pediatric gliomas. - Source: PubMed
Publication date: 2026/03/05
Postlmayr AndreasSanchez Bergman AstridTorrejon Diaz JacobCiraulo BernardYan ShenHofmann NinaCarbajal SamantaDobler RosalieMachaalani CharbelSchönholzer Marc TPriego Gonzalez LauraDe Micheli Andrea JBerenjeno-Correa ErnestoBaroncini LucaGrotzer Michael ATabori UriHawkins CynthiaAyrault OlivierZuckermann MarcBaumgartner MartinGuerreiro Stücklin Ana S - - Source: PubMed
Publication date: 2026/03/05
- Residual feed intake (RFI) is a key indicator of feed efficiency in poultry. Although regulatory links such as the hypothalamus-gut and gut-liver axes have been implicated, most studies remain restricted to single axes or fragmented analyses, and systematic multi-organ integration is lacking. Here, we measured feed efficiency in 1,000 Nonghua ducks and selected 12 individuals with divergent RFI for transcriptomic profiling of the hypothalamus, pituitary, liver, duodenum, jejunum, ileum, and cecum, combined with serum metabolomics. We identified 769 differentially expressed genes (DEGs), with the hypothalamus, liver, and cecum as major contributors, and 28 differential serum metabolites enriched in lipid and amino acid metabolism. Beyond tissue-specific functions, enrichment analysis highlighted several pathways that were repeatedly shared across central and peripheral tissues, including neuroactive ligand-receptor interaction, hormone signaling, steroid hormone biosynthesis, and insulin signaling, suggesting a coordinated regulation of feed efficiency between the brain, gut, and liver. To clarify their relevance, we integrated gene modules with metabolites and identified two candidate cross-organ association frameworks: the MEblack-6-Oxopiperidine-2-carboxylic acid (gut-liver) networks, enriched for liver genes CNTNAP1, SHC3, and RAB36, and cecal genes DCC and CCDC60. The MEblue-LysoPE(18:2(9Z,12Z)/0:0) (gut-brain) networks, enriched for cecal genes FABP6, KCNJ11, and the pituitary gene TRPA1, in which these genes and metabolites may contribute to RFI regulation. Together, these findings provide new insights into cross-organ molecular networks underlying feed efficiency in ducks and establish a valuable resource for future functional studies and breeding strategies. - Source: PubMed
Publication date: 2026/01/27
Guo ShihaoXi YangQi JingjingYang ZhaoHan XuLing WeikangBai LiliHuang AnqiHu ShenqiangHu JiweiHan ChunchunWang JiwenLi LiangLiu Hehe - Lung adenocarcinoma (LUAD), the most common subtype of non-small cell lung cancer (NSCLC), is characterized by high mortality rates and complex immune evasion mechanisms. Natural killer (NK) cells play a crucial role in tumor immune surveillance, with their activity regulated by specific genes. Recently, biomarkers derived from NK cell-related genes have garnered significant attention for their potential in predicting cancer prognosis. This study aimed to evaluate the clinical utility of a prognostic model based on NK cell-related genes in patients with LUAD. - Source: PubMed
Publication date: 2025/08/27
Zhu MinqiWang LikangChen Fang - Cepharanthine Hydrochloride (CH) is widely used in clinical settings to alleviate leukopenia caused by various tumors following radiotherapy and chemotherapy. However, it remains unclear whether CH have an inhibitory effect on the progression of prostate cancer, and whether this effect is mediated by gut microbiota. To address this question, the present study constructed normal mouse models of prostate cancer, as well as antibiotic-treated mouse models of prostate cancer. - Source: PubMed
Publication date: 2025/08/13
Li HuiLuo XingHe PengDong ZongmingJia YongmingSun BishaoZheng JiZhu Jingzhen