Ask about this productRelated genes to: CLCN6 Blocking Peptide
- Gene:
- CLCN6 NIH gene
- Name:
- chloride voltage-gated channel 6
- Previous symbol:
- -
- Synonyms:
- CLC-6, KIAA0046, ClC-6
- Chromosome:
- 1p36.22
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-21
- Date modifiied:
- 2016-02-04
Related products to: CLCN6 Blocking Peptide
Related articles to: CLCN6 Blocking Peptide
- Genome-wide association studies (GWAS) have identified numerous lung cancer susceptibility loci based on single nucleotide polymorphisms (SNPs), yet a substantial proportion of heritability remains unexplained. We therefore evaluated germline copy number variants (CNVs) as an underexplored source of genetic susceptibility and potential contributors to genomic instability in lung cancer. - Source: PubMed
Publication date: 2026/05/15
Xiao FeifeiQin FeiLuo XizhiSlewitzke Shannon EFernandes Gail FJohansson MattiasXiao XiangjunZaridze DavidBojesen Stig EgilShete SanjayAlbanes DemetriosAldrich Melinda CTardon AdoninaFernandez-Tardon GuillermoLe Marchand LoïcRennert GadBickeböller HeikeWichmann H-ErichRisch AngelaMuley ThomasRosenberger AlbertField John KDavies MichaelWoll PenellaKiemeney Lambertus AHaugen AageZienolddiny ShanbehLam StephenJohansson MikaelGrankvist KjellSchabath Matthew BAndrew AngelineLazarus PhilipArnold Susanne MZhu DakaiBrenner HermannNeuhouser Marian LHung Rayjean JChristiani David CMcKay JamesCai GuoshuaiXia JunAmos Christopher I - Epilepsy is a prevalent chronic neurological disorder characterised by recurrent seizures caused by excessive neuronal discharge. Disruptions in chloride ion homeostasis significantly affect neuronal excitability, and play a crucial role in the pathophysiology of this disorder. This review highlights the emerging importance of chloride voltage-gated channels in epilepsy, which has been largely underappreciated compared to cation channels. Recent studies have suggested that genetic alterations in chloride channels, such as CLCN1, CLCN2, CLCN3, CLCN4, and CLCN6, contribute to neuronal excitability and seizure susceptibility, with variations in these channels acting more as susceptibility factors than direct causes. However, there is a significant gap in the research on other chloride channels, particularly ClC-Ka, ClC-Kb, ClC-5, and ClC-7, whose roles in epilepsy remain underexplored. Future research should focus on these channels to better understand their contribution to the pathophysiology of epilepsy. The incorporation of genetic tests for chloride channel variants in clinical practice could provide valuable insight into the aetiology of epilepsy, leading to improved diagnostic and therapeutic strategies for affected individuals. - Source: PubMed
Publication date: 2025/03/28
Ni Ming-MingSun Jie-YuLi Zheng-QianQiu Jin-ChunWu Chun-Feng - This study aims to characterize dysregulation of phosphorylation for the 5XFAD mouse model of Alzheimer disease (AD). Employing global phosphoproteome measurements, we analyze temporal (3, 6, and 9 months) and sex-dependent effects on mouse hippocampus tissue to unveil molecular signatures associated with AD initiation and progression. Our findings reveal consistent phosphorylation of known AD biomarkers APOE and GFAP in 5XFAD mice, alongside candidates BIG3, CLCN6, and STX7, suggesting their potential as biomarkers for AD pathology. In addition, we identify PDK1 as a significantly dysregulated kinase at 9 months in females, and the regulation of gap junction activity as a key pathway associated with Alzheimer disease across all time points. AD-Xplorer, the interactive browser of our dataset, enables exploration of AD-related changes in phosphorylation, protein expression, kinase activities, and pathways. AD-Xplorer aids in biomarker discovery and therapeutic target identification, emphasizing temporal and sex-specific nature of significant phosphoproteomic signatures. Available at: https://yilmazs.shinyapps.io/ADXplorer. - Source: PubMed
Publication date: 2024/09/13
Yılmaz SerhanBlasco Tavares Pereira Lopes FilipaSchlatzer DanielaWang RihuaQi XinKoyutürk MehmetChance Mark R - - Source: PubMed
Publication date: 2024/08/29
- Mass spectrometry (MS)-based cerebrospinal fluid (CSF) proteomics is an important method for discovering biomarkers of neurodegenerative diseases. CSF serves as a reservoir for interstitial fluid (ISF), and extensive communication between the two fluid compartments helps to remove waste products from the brain. - Source: PubMed
Publication date: 2024/08/03
Górska Anna MariaSantos-García IreneEiriz IvanBrüning ThomasNyman TuulaPahnke Jens