Ask about this productRelated genes to: KHDRBS1 Blocking Peptide
- Gene:
- KHDRBS1 NIH gene
- Name:
- KH RNA binding domain containing, signal transduction associated 1
- Previous symbol:
- -
- Synonyms:
- Sam68, p62, FLJ34027
- Chromosome:
- 1p35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-28
- Date modifiied:
- 2016-10-05
Related products to: KHDRBS1 Blocking Peptide
Related articles to: KHDRBS1 Blocking Peptide
- Kidney fibrosis is a hallmark of chronic kidney disease (CKD), yet its underlying mechanisms remain incompletely understood. Retinoic acid receptor responder protein 1 (RARRES1) is largely restricted to podocytes in healthy kidneys but was upregulated within the tubulointerstitium in CKD. However, its functional contribution to kidney fibrosis remains unclear. - Source: PubMed
Publication date: 2026/04/09
Ye LinJiang ZhuoyuanWu YongZeng YaoChen XiangjunFeng BaiyuYin LijunGao YananXu WeimingYan ShuxiangLi YuWu JinshanLi QifuChen Anqun - T cells recognize their target cells through the T cell receptor (TCR). Combining gain-of-function, single-cell and optical high-content screens, we identified RNA-based mechanisms that selectively sensitize target cells to TCR-specific T cell cytotoxicity. First, CRISPR activation screens in melanoma cells identify functionally diverse regulators of TCR-specific cytotoxicity, including SAFB, KHDRBS1, MYC, CD44, WNT3A, WNT1 and others. Expressing sensitizing hits in cancer and virally infected cells restores TCR-specific cytotoxicity. Next, we developed in situ Perturb-seq for optical pooled genetic screens with in situ detection of perturbations and spatial transcriptomic readouts. Perturb-seq and in vivo-in situ Perturb-seq show that the hits converge on shared cell-autonomous and intercellular mechanisms, map gene-environment interactions and reveal that Wnt ligands activate T cells. Introducing a scalable approach to decode gene function at the cell and tissue level, the study uncovered context-specific gene functions to restore targeted T cell-based elimination of dysfunctional cells via synthetically lethal, RNA-based interventions. - Source: PubMed
Publication date: 2026/04/07
Akana Reece VillarinYoe JeehyunLaveroni OliviaSun ChangKim Young-MinJerby Livnat - Acute myeloid leukemia (AML) is a complex hematological malignancy with high mortality, particularly in the elderly. Current treatments, including chemotherapy, targeted therapies, and emerging immunotherapies such as T cell engager (TCE) and CAR-T, face challenges such as drug resistance. Lactylation, a novel post-translational modification, has emerged as a potential regulator of cellular activities and may play a role in AML pathogenesis. - Source: PubMed
Publication date: 2025/11/27
Dai RuixueSui Guodong - Focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) are major causes of primary nephrotic syndrome. However, the mechanisms of liquid-liquid phase separation (LLPS)-related genes in the development of FSGS and MCD remain unclear. We retrieved the Gene Expression Omnibus (GEO) database for the expression profiles of FSGS and MCD and identified the differentially expressed genes (DEGs) related to LLPS. Algorithms including Vector Machine-Recursive Feature Elimination (SVM-RFE) and Random Forest (RF) were adopted to identify the candidate genes. Functional enrichment analysis, nomogram, immune infiltration analysis, the receiver operating characteristic ROC) curve analysis, and external validation were performed. The research identified 59 and 40 DEGs related to LLPS for FSGS and MCD, respectively. Two candidate genes [PDS5 cohesin-associated factor A (PDS5A) and exosome component 2 (EXOSC2)] were obtained for FSGS, and three candidate genes [PDS5A, KH RNA-binding domain-containing signal transduction-associated 1 (KHDRBS1), and JunD proto-oncogene (JUND)] were obtained for MCD. Both the nomogram and ROC analysis indicated that the candidate genes had good predictive performance. For FSGS, the area under the curve (AUC) values of PDS5A and EXOSC2 were 0.994 and 0.806, respectively. For MCD, the AUC values of PDS5A, KHDRBS1, and JUND were 1, 0.896, and 0.958, respectively. Immune infiltration analysis revealed that FSGS patients had higher levels of naive B cells while MCD patients had higher levels of M2 macrophages and resting mast cells.PDS5A may represent a potential diagnostic biomarker, and targeting its aberrant phase separation may offer a therapeutic strategy for podocytopathies. - Source: PubMed
Publication date: 2025/10/19
Lu HuijuanSun JiaSun Jieqiong - Breast cancer is a very common disease affecting females on a global scale. It is responsible for approximately 10% of breast cancer-related fatalities. In 2022, approximately 2,308,897 new cases were reported globally. Recent studies focused on breast tumors have successfully recognized somatic mutations. This study aimed to identify previously unidentified somatic mutations in breast cancer patients belonging to Pakistan. - Source: PubMed
Publication date: 2025/07/31
Nawaz YasirMunir SabaTanvir FouziaRiaz Hafiza FizzahNawaz AqeelaRiaz Samreen