Ask about this productRelated genes to: SFTPD Blocking Peptide
- Gene:
- SFTPD NIH gene
- Name:
- surfactant protein D
- Previous symbol:
- SFTP4
- Synonyms:
- SP-D, COLEC7
- Chromosome:
- 10q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-26
- Date modifiied:
- 2016-10-05
Related products to: SFTPD Blocking Peptide
Related articles to: SFTPD Blocking Peptide
- Acute respiratory distress syndrome (ARDS) is a significant contributor to ICU admissions, morbidity, and mortality. Biomarkers have increasingly been used to dissect heterogeneity and mechanisms underlying pediatric ARDS. We sought to assess the genetic contribution to the levels of protein biomarkers currently used to subphenotype pediatric ARDS patients. - Source: PubMed
Publication date: 2026/08/17
Helman GuyFeng RuiMotelow Joshua EYehya Nadir - Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder influenced by environmental exposures and genetic susceptibility. Despite numerous studies, the effects of key susceptibility genes remain inconsistent across populations, and their overall clinical relevance is unclear. - Source: PubMed
Publication date: 2026/06/10
Dasgupta SanjuktaDuttagupta SubhangiPatra PranayParida SurajaDeb Sristi - Chronic obstructive pulmonary disease (COPD) is exacerbated by inflammatory reactions triggered by cigarette smoke, air pollutants, dusts, and chemical products. In order to have a better understanding of the disease, its effect on the function of lung specific genes formaldehyde induced COPD mice model were developed. Mice were administered different doses of formaldehyde intraperitoneally, and expression of SFTPD and GSTα4 genes were determined. Some in silico approaches were also adopted to evaluate the diagnostic significance of the SFTPD and GSTα4 genes. Histopathological examination showed significant lung tissue damage indicative of COPD pathology in formaldehyde administered mice groups. The expression of SFTPD and GSTα4 genes were significantly downregulated in the lung tissues of FA administered mice in a dose dependent manner. ADMET analysis indicated that formaldehyde has favorable water solubility and high intestinal absorption, but is linked to skin sensitization and hepatotoxicity. Docking results depicted that formaldehyde's interaction with SFTPD and GSTα4 may lead to decreased expression of these genes and may impair lung function. Overall, the study has provided an insight into the toxic and deteriorating effects of formaldehyde on the respiratory system and underscores the promise of SFTPD and GSTα4 as diagnostic and prognostic biomarkers for COPD. - Source: PubMed
Publication date: 2026/06/06
Waheed SanaAfzal AdnanEjaz SaimaZahra Shan EAkhtar BushraNaz MinahilZia SaadiyaSulman AbuNaeem Muhammad SaadChoriyev AbubakirRuzieva MukhayyaQizi Zaribova Nafisa Umirbay - Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with hypoxia contributing to tumor progression and treatment resistance. Identifying hypoxia-related biomarkers could enhance prognosis and therapeutic strategies for LUAD. - Source: PubMed
Publication date: 2026/06/03
Alghamdi BandarRocha Sonia - COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents a broad spectrum of clinical manifestations, ranging from asymptomatic cases to severe, life-threatening respiratory complications. Pulmonary surfactant-associated protein D (SP-D) is a critical component of pulmonary immune defense. The objective of this study was to investigate the association between a specific single-nucleotide polymorphism (SNP) in the SP-D gene, designated as rs721917 (C/T Met31Thr), and its potential impact on susceptibility to and severity of COVID-19. - Source: PubMed
Kolsari Nadia NasirzadehAzaran AzarakhshPirmoradi RoyaMoradi MaryamNashibi RoohangizJalilian Shahram