Ask about this productRelated genes to: ZNF280B Blocking Peptide
- Gene:
- ZNF280B NIH gene
- Name:
- zinc finger protein 280B
- Previous symbol:
- ZNF279, SUHW2
- Synonyms:
- 5'OY11.1, ZNF632
- Chromosome:
- 22q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-19
- Date modifiied:
- 2016-10-05
Related products to: ZNF280B Blocking Peptide
Related articles to: ZNF280B Blocking Peptide
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematopoietic neoplasm that affects humans as well as dogs. While previous studies on canine DLBCL (cDLBCL) have significantly advanced our understanding of the disease, the majority of this research has relied on whole-exome sequencing, which is limited in its ability to detect copy number aberrations and other genomic changes beyond coding regions. Furthermore, many of these studies lack sufficient clinical follow-up data, making it difficult to draw meaningful associations between genetic variants and patient outcomes. Our study aimed to characterize the mutational landscape of cDLBCL using whole-genome sequencing of matched tumor-normal samples obtained from a cohort of 43 dogs previously enrolled in a clinical trial for which longitudinal follow-up was available. We focused on identifying genes that were significantly or recurrently mutated with coding point mutations, copy number aberrations, and their associations with patient outcomes. We identified 26 recurrently mutated genes, 18 copy number gains, and 8 copy number losses. Consistent with prior studies, the most commonly mutated genes included TRAF3, FBXW7, POT1, TP53, SETD2, DDX3X and TBL1XR1. The most prominent copy number gain occurred on chromosome 13, overlapping key oncogenes such as MYC and KIT, while the most frequent deletion was a focal loss on chromosome 26, encompassing IGL, PRAME, GNAZ, RAB36, RSPH14, and ZNF280B. Notably, our set of recurrently mutated genes was significantly enriched with genes involved in epigenetic regulation. In particular, we identified hotspot mutations in two histone genes, H3C8, and LOC119877878, resulting in H3K27M alterations predicted to dysregulate gene expression. Finally, a survival analysis revealed that H3K27M mutations in H3C8 were associated with increased hazard ratios for progression-free survival. No copy number aberrations were associated with survival. These findings underscore the critical role of epigenetic dysregulation in cDLBCL and affirm the dog as a relevant large animal model for interrogating the biological activity of novel histone-modifying treatment strategies. - Source: PubMed
Publication date: 2025/02/08
van der Heiden Anna DarlenePensch RaphaelaAgger SophieGardner Heather LHendricks WilliamZismann VictoriaWong ShukmeiBriones NataliaTurner BryceForsberg-Nilsson KarinLondon CherylLindblad-Toh KerstinArendt Maja Louise - The purpose of this research was to investigate the role of extracellular vesicles derived from lung cancer stem cells (lung CSCs-EVs) in lung cancer and to explore their potential mechanisms. - Source: PubMed
Publication date: 2025/01/17
Guo QixiaLu JiayanZhao HuiZhou DingLiu Hua - Infants born preterm have a higher incidence of neurological deficits. A key step in finding effective treatments is to identify biomarkers that reliably predict outcome. - Source: PubMed
Publication date: 2024/05/31
Ek C JoakimAlkmark MårtenBaburamani Ana ASupramaniam Veena GSood SanjanaMelchiotti Rossellade Rinaldis EmanueleHagberg HenrikMallard Carina - The gene encodes a secreted protein, and the gene is a member of the transcription factor family. Both genes have multiple biological functions. This study was conducted to investigate the association between and gene polymorphisms and wool fiber diameter and to determine potential molecular marker sites for breeding sheep with fine wool. We used Kompetitive Allele-Specific PCR to type the single nucleotide polymorphism (SNP) loci in the and genes within 1081 Alpine Merino sheep and associated these SNPs with wool fiber diameter. The results revealed one SNP in and , which were each related to sheep fiber diameter. The wool fiber diameters of sheep with the CC genotype in g.478807C>G and AA genotype in g.677G>A were the smallest and differed significantly from the diameters of other genotypes ( < 0.05). These results suggest potential molecular marker sites for fine-wool sheep breeding. - Source: PubMed
Publication date: 2023/11/17
Yue LinLu ZengkuiGuo TingtingLiu JianbinYuan ChaoYang Bohui - Adult T-cell Leukemia/Lymphoma (ATLL) is a rapidly progressing type of T-cell non-Hodgkin lymphoma that is developed after the infection by human T-cell leukemia virus type 1 (HTLV-1). It could be categorized into four major subtypes, acute, lymphoma, chronic, and smoldering. These different subtypes have some shared clinical manifestations, and there are no trustworthy biomarkers for diagnosis of them. - Source: PubMed
Publication date: 2023/03/28
Ghobadi Mohadeseh ZareiAfsaneh ElahehEmamzadeh RahmanSoroush Mona