Ask about this productRelated genes to: PAPPA2 Blocking Peptide
- Gene:
- PAPPA2 NIH gene
- Name:
- pappalysin 2
- Previous symbol:
- PLAC3
- Synonyms:
- PAPPE, PAPP-A2
- Chromosome:
- 1q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-03
- Date modifiied:
- 2015-08-25
Related products to: PAPPA2 Blocking Peptide
Related articles to: PAPPA2 Blocking Peptide
- Medulloblastoma is one of the most common malignant pediatric brain tumors. There remain significant challenges in investigating oncogenic mechanisms and evaluating therapeutic efficacy due to the limited available models that accurately reflect tumor heterogeneity. To overcome this limitation, we established 10 patient-derived medulloblastoma organoids (MBOs) that retain the histological characteristics, and cellular diversity of the original tumors. These MBOs demonstrate strong infiltration capabilities, both through co-culture with human embryonic stem cell-derived cerebral organoids and following orthotopic or subcutaneous transplantation, establishing a potential platform for investigating interactions within the tumor microenvironment. Using integrated RNA sequencing, whole-exome sequencing, and DNA methylation profiling, we demonstrated that MBOs faithfully preserve the transcriptional, genomic, and epigenetic landscapes of their parental tumors. Single-cell transcriptomic analysis revealed conserved cellular subpopulation between MBOs and primary tumors. Our findings suggest that photoreceptor-related pathways may play an unprecedented role in the pathogenesis of Group 4 medulloblastoma and may be associated with interactions within the tumor microenvironment. Furthermore, we developed a prognostic nomogram based on IMPG2, BNC2, PAPPA2, ITGBL1and UNC13C expression levels in tumor cells to predict survival outcomes. Notably, tumor-infiltrating lymphocytes (TILs) expanded from patient specimens exhibited significant cytotoxic activity against autologous MBOs co-cultured and effectively suppressed the growth of subcutaneous MBO xenografts . These findings demonstrate the potential of TIL-based immunotherapy for medulloblastoma treatment. Collectively, our MBO system faithfully recapitulates critical tumor characteristics and serves as a valuable platform for investigating tumorigenic mechanisms and assessing therapeutic responses. This study not only promotes fundamental biological research but also accelerates clinical translation in medulloblastoma. - Source: PubMed
Publication date: 2026/04/23
Zhang JitingWang MinRui HuanwenWang CenLuo GuanghaoNiu ZhiyuanShi WeiZeng JunweiXue PingShi XueyaoYan BingRen WenyanLi HaoLin Xinhua - Recombinant human (rh) insulin-like growth factor-1 (IGF1) treatment has been shown to restore growth velocity and height in children harbouring pregnancy-associated plasma protein-A2 () mutations. The present study aimed to evaluate whether pharmacological modulation of the growth hormone (GH)/IGF1 system elicits sex-specific improvements in bone growth in a deficient mouse model of growth impairment, and to identify the associated signalling pathways. - Source: PubMed
Publication date: 2026/05/13
Fernández-Arjona María Del MarLópez-Gambero Antonio JRubio LeticiaRodríguez-Pozo MiguelRivera Patriciade Ceglia MarialuisaVargas AntonioRodríguez de Fonseca FernandoChowen Julie AArgente JesúsSuárez Juan - Analysis of runs of homozygosity (ROH) in commercial breed genomes is important for accurately assessing the population inbreeding status and exploring homozygous regions related to economic traits formed by selection pressure. The Danish Large White (LW) pig is a commercially important breed renowned for its superior growth efficiency and reproductive performance. In the present study, we identified ROH segments of Danish LW pigs based on 43 individual whole-genome resequencing data. We then calculated the inbreeding coefficient and screened candidate genes with important economic traits from the ROH islands. A total of 9446 ROH segments were identified in the LW pig population. Each LW pig carried 219.67 ROH. Most ROH were , and the average genomic inbreeding coefficient ( ) in LW pigs was 0.24. However, the proportion of ROH ( ) in LW pigs has reached 10 %, indicating selection pressure or inbreeding in recent times. Candidate genes related to reproductive traits (, , , , , , and ), and growth and development traits (, , , , , , , , , , and ) were identified in the genomic ROH islands of LW pigs. In conclusion, the present study provides further assessment of genetic diversity and inbreeding in the Danish LW pig population. In addition, our results provide useful insights into the functions of ROH on a hereditary basis and the role that ROH play in controlling the excellent characteristics of Danish LW pigs. - Source: PubMed
Publication date: 2026/01/12
Ding WeiminWu XudongBu YuZhang WeiWang YuanlangDing YueyunZheng XianruiZhang XiaodongYin Zongjun - Approximately 60% of glaucoma patients have a family history. Family-based studies indicate that relatives of glaucoma patients have a 10-fold higher risk of developing glaucoma compared to the control population. Genetic mutations have been reported as potential contributing factors to pathogenesis of glaucoma. In this study, we reported a Chinese family that many members affected with primary open-angle glaucoma carried a c.392G>C heterozygous mutation. Western blotting results showed that this mutation decreased PAPPA2 protein level. Strikingly, we found PAPPA2 and its substrate IGFBP5 both expressed in human aqueous humor samples, and PAPPA2 levels significantly decreased in the POAG group accompanied with IGFBP5 levels increased in the POAG group. We also demonstrated that PAPPA2 cleaved IGFBP5 in vitro. We found that overexpressed IGFBP5 increased many fibrosis-related gene expression through mRNA sequencing, western blotting, and immunofluorescence staining assays in primary human trabecular meshwork cells (HTMCs). More importantly, we found an inadequate dose of Pappa2 caused POAG-like phenotypes in the mouse model. So, we proved the vital function of the eye local PAPPA2-IGFBP5 axis in regulating extracellular matrix homeostasis and contributing to trabecular meshwork fibrosis and pathogenesis of POAG. - Source: PubMed
Publication date: 2026/04/15
Wang GangGuo ZiluRen JingZhang GeTao HanlinLiu YihanZheng SimingZhang XuanWang DiZhao RumengCui HuilingZhu ShichaoXu HongenDuan ShichaoLi Haijun - Anabolic androgenic steroids (AAS) may exert effects through the insulin-like growth factor (IGF) system. We compared the IGF system in male and female recreational athletes who were current or former AAS users and non-users. - Source: PubMed
Buhl Laust FrisenbergChristensen Louise LehmannBulut YelizHasific SelmaHarders StefanGlintborg DorteAndersen Marianne SThevis MarioKistorp CarolineRasmussen Jon JarløvLindholt Jes SDiederichsen AxelFrystyk JanHjortebjerg Rikke