Ask about this productRelated genes to: CDCA7L Blocking Peptide
- Gene:
- CDCA7L NIH gene
- Name:
- cell division cycle associated 7 like
- Previous symbol:
- -
- Synonyms:
- RAM2, R1, JPO2
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-13
- Date modifiied:
- 2016-02-03
Related products to: CDCA7L Blocking Peptide
Related articles to: CDCA7L Blocking Peptide
- - Source: PubMed
Publication date: 2025/09/16
Xiao MeimeiQiu YueJiang CancaiZhang ChenhaoYao Jun - Numerous studies have confirmed that ginsenoside Rg1 can promote wound healing in diabetic foot ulcers (DFU), yet the underlying mechanisms remain unclear. This study aimed to investigate the function of miR-155 in Rg1-mediated DFU wound healing and its regulatory mechanism. - Source: PubMed
Publication date: 2025/05/30
Xiao MeimeiQiu YueJiang CancaiZhang ChenhaoYao Jun - This study utilized a genome-wide association study (GWAS) to investigate the genetic variations linked to the risk of hepatitis B virus (HBV) reactivation in patients who have undergone liver transplantation (LT), aiming to enhance understanding and improve clinical outcomes. Genotyping performed on a selected patients from the Korean Organ Transplantation Registry (KOTRY) data using high-throughput platforms with the Axiom Korea Biobank array 1.1. The discovery cohort included 21 patients who experienced HBV reactivation (cases) and 888 patients without HBV reactivation (controls) following LT. The replication cohort consisted of 5 patients with HBV reactivation (cases) and 312 patients without HBV reactivation (controls) after LT. Additive logistic regression analysis was conducted using PLINK software ver 1.9, with adjustments for age and gender. The GWAS findings from the discovery cohort were validated using the replication cohort. The GWAS identified several single-nucleotide polymorphisms (SNPs) in the , , and genes that were significantly linked to HBV reactivation after LT, with genome-wide significance thresholds set at < 10. Down-regulation of cDNAs was observed in primary duck hepatocytes infected with duck HBV. Overexpression of was found to promote hepatocellular carcinoma cell proliferation and colony formation, whereas knocking down CDCA7L inhibited these processes. Additionally, the absence of AQP9 triggered immune and inflammatory responses, leading to mild and scattered liver cell pyroptosis, accompanied by compensatory liver cell proliferation. This study provides critical insights into the genetic factors influencing HBV reactivation after LT, identifying significant associations with SNPs in , , and . These findings hold promise for developing predictive biomarkers and personalized management strategies to improve outcomes for HBV-infected LT recipients. - Source: PubMed
Publication date: 2024/12/30
Park JoonhongKim Dong YunGee Heon YungYu Hee ChulYang Jae DoHwang ShinChoi YoungRokLee Jae GeunRhu JinsooChoi DonglakYou Young KyoungRyu Je HoNah Yang WonKim Bong-WanKim Dong-SikCho Jai YoungGroup The Korean Organ Transplantation Registry Kotry Study - Tertiary lymphoid structures (TLS) are formed in numerous cancer types. However, their value and significance in hepatocellular carcinoma (HCC) is unclear. - Source: PubMed
Publication date: 2024/11/19
Pu LeiZhang XiaoyanPu ChengZhou JiachengLi JianyueWang XiaorongXi ChenpengZhang Chunyuan - Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associated with inflammation-related traits. The effect of PUFAs on health outcomes might be mediated by DNA methylation (DNAm). The aim of our study is to identify the impact of PUFA intake on DNAm in the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and the Leiden Longevity Study (LLS). - Source: PubMed
Publication date: 2024/02/16
Lange de Luna JuliaNounu AayahNeumeyer SonjaSinke LucyWilson RoryHellbach FabianMatías-García Pamela RDelerue ThomasWinkelmann JulianePeters AnnetteThorand BarbaraBeekman MarianHeijmans Bastiaan TSlagboom ElineGieger ChristianLinseisen JakobWaldenberger Melanie