Ask about this productRelated genes to: GLIS3 Blocking Peptide
- Gene:
- GLIS3 NIH gene
- Name:
- GLIS family zinc finger 3
- Previous symbol:
- ZNF515
- Synonyms:
- MGC33662
- Chromosome:
- 9p24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-22
- Date modifiied:
- 2014-11-19
Related products to: GLIS3 Blocking Peptide
Related articles to: GLIS3 Blocking Peptide
- GLIS family zinc finger 3 (GLIS3) is a transcription factor implicated in multiple malignancies, but its role in stomach adenocarcinoma (STAD) and its downstream effector axis remain unclear. We investigated whether GLIS3 coordinates epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like programs in STAD through a signaling cascade. - Source: PubMed
Publication date: 2026/05/21
Xiao QiDeng HongyangLi JipinZheng YijunZhang Youcheng - Hyalinizing trabecular tumor (HTT) of the thyroid is an uncommon follicular cell-derived neoplasm. Histologically, it shares several nuclear features with papillary thyroid carcinoma (PTC), such as nuclear grooves and pseudoinclusions, making accurate diagnosis challenging, particularly in cytology. Coexistence of HTT and PTC within the same thyroid gland is exceptionally rare and can further complicate clinical interpretation. - Source: PubMed
Publication date: 2026/02/03
Charolia Mubashirah SRani AlkaMemon Aisha HassanAnwar ShayanFatima Saira - Non-small-cell lung cancer (NSCLC) constitutes approximately all lung cancers (LCs), and metastasis remains a major challenge in its treatment, thus necessitating the detection of novel molecular players involved in this process. In this study, we performed a comprehensive analysis of microarray and RNA-seq cohorts extracted from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) and associated them with metastasis-related genes involved in brain metastasis (BM) in NSCLC. We thus identified differentially expressed metastatic genes (DEMGs) and constructed a protein-protein interaction network (PPIN) using these DEMGs. These DEMGs were further analyzed for associations with patient age, gender, and tumor stage, and the significant impact of specific genes on overall survival (OS) was assessed to determine the prognostic significance of the identified targets. We finally constructed a three-node microRNA (miRNA) feed-forward loop (FFL) involving miR-23b-3p, CD44, and five transcription factors (TFs) [EOMES, FOS, FOSL1, GLIS3, TP63] specific to NSCLC metastasis. Further mutational analysis of these FFL elements revealed that all were altered in the patient samples analyzed. Thus, our study identified potential genomic drivers that may play crucial roles in NSCLC BM. Overall, it provides valuable insights for the discovery of novel therapeutic targets in the management of NSCLC metastasis. However, further in vitro and in vivo experimentations are needed to justify the prognostic role of NSCLC biomarkers in BM pathogenesis. - Source: PubMed
Publication date: 2026/04/17
Singh PrithviDohare RavinsSarwar TariqueAlharbi Hajed Obaid ARahmani Arshad Husain - Pancreatic ductal adenocarcinoma (PDAC) frequently recurs and metastasizes despite intensive therapy. The neural-like progenitor (NRP) transcriptional program is enriched in residual disease after neoadjuvant chemotherapy and radiotherapy, but its basis has remained unclear. We hypothesized that NRP represents a regeneration program co-opted by tumors recovering from cytotoxic injury. NRP signatures were strongly enriched in normal pancreatic injury and regeneration, and NRP cancer cells co-expressed transcription factors involved in pancreatic development. Our data support cell-intrinsic contributions and implicate IL-1β-associated inflammatory signaling as a plausible microenvironmental driver of elevated NRP expression. To enable direct phenotypic comparison with other cancer cell states, we established isogenic mouse organoid overexpression models for transcription factors linked to NRP, classical, and basal-like states. Glis3 emerged as a key NRP-associated factor, promoting clonogenicity, tumor growth, and metastasis. These findings identify a clinically relevant developmental regeneration program that emerges in PDAC after treatment. - Source: PubMed
Publication date: 2026/04/27
Gong DennisGuo Jimmy ASu JenniferCetinkaya SuedaHennessey ConnorYu PatrickJambhale AnanyaWang Peter LCaldwell Nicholas JLam AshleyWang JunningShiau CarinaKapner Kevin SDilly JulienAbbassi LalehChugh SeemaDasgupta ShatavishaNowak JonathanWolpin Brian MZhang M LisaMino-Kenudson MariJacks TylerAguirre Andrew JHwang William L - Background and objectives Gestational diabetes mellitus (GDM) increases the chances of negative consequences for both the mother and the foetus. It shares genetic and physiological characteristics with type 2 diabetes mellitus (T2DM), particularly insulin resistance and impaired insulin secretion. While gene variants involved in glucose metabolism, such as those in glucokinase receptor (GCKR) and GLI similar 3 (GLIS3), have been linked to diabetes risk, their association with GDM in South Indian populations remains underexplored. Methods This study comprised 195 patients with GDM and 195 normoglycemic pregnant women of South Indian ethnicity. GDM diagnosis was recognised using an oral glucose tolerance test. Genotyping of GCKR (rs780094) and GLIS3 (rs701847, rs7020673, rs10814916) were performed using Tetra-ARMS PCR and validated through Sanger sequencing. Associations between genotypes and the risk of GDM were assessed using logistic regression. Results Women with GDM exhibited significantly higher age, body mass index, blood pressure, and adverse metabolic profiles. There was a strong genotype-specific correlation between GDM and the GCKR rs780094 CT genotype. When dominant models and the AG genotype were used, rs701847 exhibited the strongest correlation with GLIS3. rs10814916 was linked through the AC genotype, whereas rs7020673 only demonstrated a connection under the recessive model. In women with GDM, HOMA-IR was significantly higher (P<0.001). Interpretation and conclusion This study highlights significant associations between GCKR and GLIS3 polymorphisms and the risk of GDM in South Indian women, supporting the role of ethnicity-specific genetic screening in predicting GDM risk. - Source: PubMed
Muruganantham Jethendra KumarKandasamy VijayalakshmiVeerabathiran Ramakrishnan