Ask about this productRelated genes to: BEST3 Blocking Peptide
- Gene:
- BEST3 NIH gene
- Name:
- bestrophin 3
- Previous symbol:
- VMD2L3
- Synonyms:
- MGC40411, MGC13168
- Chromosome:
- 12q15
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-03
- Date modifiied:
- 2015-01-28
Related products to: BEST3 Blocking Peptide
Related articles to: BEST3 Blocking Peptide
- is an economically important freshwater prawn species in China, where larger individuals have higher commercial value than smaller ones. Previous studies indicated that bestrophin 3 () may play a regulatory role in the growth performance of this species. Therefore, the present study investigated the potential functions of the gene in the growth of by using quantitative real-time PCR (qPCR) and RNA interference (RNAi), and also searched for growth-related single-nucleotide polymorphisms (SNPs) within this gene. qPCR results revealed that expression was widely detected across all tested tissues, suggesting that this gene may serve multiple functions in . Notably, its highest expression was observed in muscle tissue, which was significantly greater than that in all other tested tissues ( < 0.05), implicating a potential role for this gene in growth regulation. Further qPCR analysis confirmed that the synthesized effectively reduced expression. The body mass gain percentage in the -injected group was significantly lower than that in the -injected control group, with differences becoming significant from Day 12 onward in both males and females ( < 0.05). These findings indicate that plays a positive role in regulating growth in . Finally, three SNPs were identified in the coding region of this gene. The associations of these three SNPs with growth performance, including body weight and total length, were further validated using 50 male and 50 female prawns derived from a full-sib family at approximately 5 months post-hatching. Among them, one SNP (S31_23192836) was found to be associated with growth performance in both male prawns and female prawns. Overall, this study confirmed the positive regulatory role of in the growth of and identified growth-related SNPs within this gene. These results improve our understanding of the molecular mechanisms underlying growth regulation and support the production of populations with superior growth traits through marker-assisted selection. - Source: PubMed
Publication date: 2026/06/13
Jin ShuboGao ZijianFu HongtuoXiong YiweiQiao HuiZhang WenyiJiang Sufei - Gene mutations and altered epigenetic regulation of gene expression are characteristic features of malignant neoplasms. Combinations of these abnormalities form molecular features of individual tumors. In the large-scale Dependency Map (DepMap) project, the broad panels of human tumor cell lines are being tested for sensitivity to single gene inactivation. Using DepMap data, we have previously identified a set of genes termed supertargets, the deletion of which significantly reduced the survival of cells of a particular tissue origin while minimally impairing the unrelated cell lines. In the present study, we determined the factors of viability (inhibition of proliferation or death) of cell lines in which the supertarget genes have been deleted. We found that, in 79 % of cases, the reduced survival may be caused by epigenetic changes of gene expression. In the remaining 21 % of cases, it is associated with altered gene structure. Three groups containing different types of gene expression alterations can be distinguished. In the first group, the reduced cell survival correlated with a higher expression of the supertarget gene (e. g., SOX10 and HNF1B). In the second group, a gene different from the deleted supertarget was overexpressed (gene pairs: FOXA1 and SPDEF, TP63 and SERPINB13, etc.). The third group was characterized by correlations between low expression of a certain gene and tumor cell sensitivity (e. g., FAM126A and FAM126B, SMARCA2 and SMARCA4). The genetic changes included GOF mutations (KRAS, BRAF genes, etc.), LOF mutations (STAG1, SMARCA2 genes, etc.), gene fusions (BCR-ABL1, PAX3-FOXO1, etc.), and amplification (CPM, BEST3, etc.). Therefore, many different molecular mechanisms act as predictors of tumor cell response to inhibition of supertarget genes. - Source: PubMed
Chetverina D AKozelchuk N YLomaev D VShtil A AErokhin М M - - Source: PubMed
Publication date: 2025/06/16
Fitzgerald Rebecca CSasieni Peter - Mandibular prognathism (MP) is a type of malocclusion characterized by an imbalance in the anteroposterior position of the upper and lower jaws. The prevalence of MP in Japan is relatively high, suggesting a unique genetic background in the population. - Source: PubMed
Publication date: 2025/05/09
Hoshi-Numahata MarieNakanishi-Kimura AtsukoWatanabe HaruhisaNishiura MaiNishimoto ShinnosukeUeno FumiKoguchi RiyuOka AkiraSato YoshiakiKajii Takashi SIimura Tadahiro - This study investigates platelet-related subtypes in non-small cell lung cancer (NSCLC) and seeks to identify genes associated with prognosis, focusing on the clinical significance of the chloride ion channel gene BEST3. We utilised sequencing and clinical data from GEO, TCGA and the Xena platform, building a risk model based on genetic features. TCGA and GSE37745 served as training cohorts, while GSE50081, GSE13213, GSE30129 and GSE42127 were validation cohorts. Immunotherapy datasets (GSE135222, TCGA-SKCM) were also analysed. Differentially expressed genes (DEGs) were identified using Limma, subtypes through ConsensusClusterPlus and key prognostic genes using COX regression, Random Forest and LASSO-COX. BEST3 expression was validated by flow cytometry (FCM) and functional assays in A549 cells with lentiviral overexpression evaluated its impact on apoptosis, proliferation and migration. Three platelet-related subtypes were identified, with ten key prognostic genes (including BEST3). Gene Ontology (GO) analysis showed six genes involved in platelet pathways. BEST3 was highly expressed in the platelet subtype 1. Flow cytometry confirmed elevated BEST3 levels in NSCLC (35.9% vs. 27.3% in healthy individuals). Overexpression of BEST3 in NSCLC cells suppressed apoptosis and promoted proliferation and migration. The discovery of three platelet subtypes and the role of BEST3 in promoting tumour growth and migration highlights its potential as a therapeutic target and prognostic marker in NSCLC. - Source: PubMed
Ren HanxiaoDu Meng-ZeLiao YulinZu RuilingRao LubeiXiang RunZhang XingmeiLiu ShanZhang PeiyinLeng PingQi LingLuo Huaichao