Ask about this productRelated genes to: ALG6 Blocking Peptide
- Gene:
- ALG6 NIH gene
- Name:
- ALG6 alpha-1,3-glucosyltransferase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-15
- Date modifiied:
- 2019-04-23
Related products to: ALG6 Blocking Peptide
Related articles to: ALG6 Blocking Peptide
- OBJECTIVES: To compare the image quality of deep learning-based Compressed SENSE (DL-based CS) reconstructed images with conventional algorithm-based Compressed SENSE (Alg-based CS) reconstructed images in contrast-enhanced 3D T1-weighted images of the maxillofacial region. METHODS: The cases of 32 patients who underwent two reconstructions, conventional Alg-based CS, and DL-based CS, were retrospectively analyzed. We set the reduction factors to 3 and 6. Thus, four types of images were obtained: Alg3, DL3, Alg6, and DL6. We calculated the signal-to-noise ratios (SNRs) of the muscle and spinal cord and the Structural Similarity Index Measure (SSIM) between the two reconstructions at both the level of the tongue and oral floor. Additionally, noise, visualization of anatomical structures, and motion artifacts were subjectively assessed on a 5-point scale. RESULTS: A significant difference was observed between Alg3 and Alg6, indicating that a higher reduction factor results in a lower SNR. DL was useful for improving image quality, and no significant difference was observed between DL6 and Alg3. The SSIM at a reduction factor of six was smaller than that at a reduction factor of three, and this tendency was markedly noticeable in the lower face, which shows that DL is beneficial for denoising under low SNR conditions. The qualitative assessment of the noise and anatomical structure showed similar trends to the SNR. CONCLUSIONS: Given the quantitative and qualitative analyses, DL-based CS reconstruction is useful, especially for high reduction factors and regions with low coil sensitivity. - Source: PubMed
Publication date: 2026/03/26
Chikui ToruOkamura KazutoshiOhga MasahiroYamashita Koji - Coronaviruses (CoVs) constitute a major global health threat, and their replication is inseparable from host factors. Investigating host-virus interactions is critical for elucidating the CoV life cycle. Here, we identify alpha-1,3-glucosyltransferase (ALG6) as an essential host factor for CoV replication. Mechanistically, its catalytic activity governs transmissible gastroenteritis virus (TGEV) replication, and ALG6 knockout (KO) inhibits viral entry by downregulating the receptor aminopeptidase N (ANPEP). Moreover, our results indicate that ALG6 KO triggers endoplasmic reticulum (ER) stress, resulting in suppressed viral replication. Further investigations demonstrate that ALG6 KO predominantly hinders viral replication by triggering downstream autophagy induced by ER stress. Transmission electron microscopy analysis reveals that ALG6 KO disrupts the formation of double-membrane vesicles (DMVs) during the initial stages of viral replication. In summary, our findings underscore the crucial role of ALG6 in the replication of CoVs, presenting a promising avenue for the development of potential therapeutic strategies against future CoV infections. - Source: PubMed
Publication date: 2026/03/17
Fu YananGao MeijieFu ZhenSun LimengSu ZhelinTan YubeiXiang YixinShi YuejunXie ShengsongPeng Guiqing - Molecular characterization of balanced complex chromosomal rearrangements (CCR) aids in understanding the pathophysiological mechanism and corresponding genotype-phenotype correlations. The present case describes a male child with intellectual disability, developmental delay, and dysmorphism. A thorough and sequential genetic evaluation using karyotyping, fluorescence in situ hybridization (FISH), chromosomal microarray (CMA), and long read sequencing (LRS) identified a genomically balanced CCR. The CCR involved eight chromosomes, the largest to be documented till date for chromoanagenesis and being balanced despite the high level of complex chromosomal involvement. Translocations accounted for the majority of the rearrangements along with an insertion, inversion, and a small deletion likely driven by chromoplexy. Although the CCR was genomically balanced, it may still result in functionally significant genomic consequences including gene disruptions, gene fusions, and position effects. Long read whole genome sequencing using PacBio was used for breakpoint characterization that revealed three protein-coding genes to be disrupted, namely, NLGN4X, LAMA4, and ALG6. Of these, a candidate association was observed for the NLGN4X gene with the intellectual disability phenotype reported in the proband, which is likely due to disruption of transcription and nonsense mediated decay. We show combinatorial application of advanced genomic technologies with orthogonal cytogenetic techniques in delineating balanced CCRs and understanding the biological and potential clinical implications of balanced yet functionally disruptive CCRs. - Source: PubMed
Publication date: 2026/02/27
Sheth FrennyShah JhanviMuranjan MamtaLiehr ThomasPadutsch NiklasMane SrikantNg Sok Meng EvelynLi PeiningDesai ManishaKansara HenySheth Jayesh JSheth Harsh - - Source: PubMed
Matsuura RyukiKikuchi KenjiroOba AzusaOhashi HirofumiOkamoto Nobuhiko - Transmissible gastroenteritis virus (TGEV) represents a significant threat to global swine production. In the absence of effective antiviral therapies, control relies primarily on vaccination. To identify potential therapeutic targets, we performed a genome-wide CRISPR/Cas9 screen in porcine IPEC-J2 cells, which revealed asparagine-linked glycosylation 5 (ALG5), asparagine-linked glycosylation 6 (ALG6), neurofibromin 2 (NF2), and fucosyltransferase 8 (FUT8) as essential host factors for TGEV infection. Functional characterization demonstrated that ALG5, ALG6, and NF2 knockout impaired viral adsorption and internalization through disruption of aminopeptidase N (pAPN) transcription or N-glycosylation. Consistently, tunicamycin-mediated inhibition of N-glycosylation suppressed TGEV infection. In contrast, FUT8 knockout specifically affects viral internalization and early replication by preventing the formation of double-membrane vesicles (DMVs) but does not affect pAPN expression. This role was independent of FUT8's fucosyltransferase activity, as the enzymatic inhibitor FDW028 had no effect. Mechanistically, we found that FUT8 interacts with the TGEV nonstructural proteins NSP3 and NSP4 to facilitate DMV biogenesis. Our findings delineate distinct mechanisms by which host factors support TGEV infection and provide novel insights for the development of targeted antiviral strategies. - Source: PubMed
Publication date: 2025/11/06
Feng ZhihuaHe XinyanLin MinhuaZhao HengChen YaoChen JianghuaLi ZhaolongShen YangkunChen JianxinYang XiaoyuChen Qi