Ask about this productRelated genes to: Olfm3 Blocking Peptide
- Gene:
- OLFM3 NIH gene
- Name:
- olfactomedin 3
- Previous symbol:
- -
- Synonyms:
- NOE3
- Chromosome:
- 1p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-11
- Date modifiied:
- 2016-10-05
Related products to: Olfm3 Blocking Peptide
Related articles to: Olfm3 Blocking Peptide
- Maladaptive learned fear responses to stress underlie several debilitating neuropsychiatric disorders. Here, we identify a brain-to-spleen neural pathway that mediates learned fear through coordinated neuroimmune interactions. Using a chronic acquired olfactory stress (CAOS) model, we demonstrate that sustained enhancement of the piriform cortex (Pir) excitability contributes to the transformation of stress-associated olfactory inputs into learned fear-avoidance behavior. Through comprehensive neural tracing approaches, we mapped a functional tetrasynaptic circuit (Pir→ventral hippocampus CA1 subregion [vCA1]→CeM→DVC→spleen) regulating T helper 17 (Th17) cell-dependent fear responses. Single-nucleus RNA sequencing revealed that olfactomedin 3-expressing glutamatergic neurons in the Pir integrate olfactory stress inputs to activate this pathway. Importantly, targeted disruption of this circuit through either conditional knockdown of Olfm3 within Pir→vCA1 projecting glutamatergic neurons or chemogenetic inhibition of these projections eliminated CAOS-induced splenic Th17 cell expansion and fear avoidance. These findings provide fundamental insights into how learned fear becomes maladaptive by identifying a complete neural circuit linking olfactory perception to peripheral immunity. - Source: PubMed
Publication date: 2026/06/12
Yao HangQu Mei-YingDu Ren-HongZhou Zhi-YongGeng YaoZhu ZhuLiu YangWang CongHu GangCao LeiLu Ming - Human eye, skin and hair color pigmentation are highly heritable traits influenced by hundreds of genetic loci. The heritability and genetic etiology of the hyperpigmentation trait pregnancy-related linea nigra (PLN), where a dark but usually temporary vertical line develops on the abdomen, is unknown, and our understanding of its relationships with other pigmentation traits is limited. We conducted a genetic study of self-reported PLN in women of European ancestry, using a genome-based restricted maximum likelihood (GREML) method to estimate PLN heritability, performing a genomewide association study (GWAS) to explore the genetic factors underlying PLN, and calculating polygenic risk scores (PRS) to assess whether this trait shares genetic liability with two other skin pigmentation phenotypes, skin colour and mole count. We found 35% of the variance in developing PLN was explained by common genetic variation. The GWAS revealed four genomic loci suggestively associated ( values ≤ 1 × 10) with PLN: rs1263154 near the gene ( = 9.0 × 10), rs26331 near ( = 6.6 × 10), rs78371540 in ( = 5.5 × 10), and rs72693263 near ( = 1.1 × 10). Of these genes only has been previously associated with pigmentation. Our PRS results provide the first evidence that genetic factors underlying skin color and mole count also contribute to the development of PLN in women of European ancestry. - Source: PubMed
Publication date: 2025/11/04
Bivol SvetlanaSeviiri MathiasColodro-Conde LucíaMitchell Brittany LOlsen Catherine MWhiteman David CLaw Matthew HLind Penelope APainter Jodie NMedland Sarah E - Esophageal cancer (EC) ranks among the most prevalent malignancies globally and represents a significant and growing public health burden. This study aimed to construct a prognostic model leveraging anoikis-related genes (ARGs) to predict patient survival and elucidate the immunological microenvironment in EC. The findings are anticipated to enhance prognostic accuracy and inform therapeutic strategies, ultimately improving patient outcomes and treatment efficacy. - Source: PubMed
Publication date: 2025/07/11
Su YaniZhang MingXu PengWen PengfeiXu KeXie JialeWan XianjieLiu LinYang ZhiYang Mingyi - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with significant genetic heterogeneity. The ZIC gene family can regulate neurodevelopment, especially in the cerebellum, and has been implicated in ASD-like behaviors in mice. We performed bioinformatic analysis to identify the ZIC gene family in the ASD cerebellum. - Source: PubMed
Publication date: 2024/02/22
Li HeliCui JinruHu CongLi HaoLuo XiaopingHao Yan - Coleoid cephalopods have a high intelligence, complex structures, and large brain. The cephalopod brain is divided into supraesophageal mass, subesophageal mass and optic lobe. Although much is known about the structural organization and connections of various lobes of octopus brain, there are few studies on the brain of cephalopod at the molecular level. In this study, we demonstrated the structure of an adult Octopus minor brain by histomorphological analyses. Through visualization of neuronal and proliferation markers, we found that adult neurogenesis occurred in the vL and posterior svL. We also obtained specific 1015 genes by transcriptome of O. minor brain and selected OLFM3, NPY, GnRH, and GDF8 genes. The expression of genes in the central brain showed the possibility of using NPY and GDF8 as molecular marker of compartmentation in the central brain. This study will provide useful information for establishing a molecular atlas of cephalopod brain. - Source: PubMed
Publication date: 2023/05/04
Lee Chan-JunLee Hae-YounYu Yun-SangRyu Kyoung-BinLee HyerimKim KyunghwanShin Song YubGil Young-ChunCho Sung-Jin