Ask about this productRelated genes to: ZBTB32 Blocking Peptide
- Gene:
- ZBTB32 NIH gene
- Name:
- zinc finger and BTB domain containing 32
- Previous symbol:
- -
- Synonyms:
- TZFP, FAZF, FAXF, Rog, ZNF538
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-23
- Date modifiied:
- 2016-10-05
Related products to: ZBTB32 Blocking Peptide
Related articles to: ZBTB32 Blocking Peptide
- Obesity-associated inflammation in white adipose tissue (WAT) worsens outcomes of influenza A virus (IAV) infection. A recently identified thoracic cavity WAT (tcWAT) supports IAV replication. However, tcWAT's immune cell composition, functional properties and role in IAV disease severity remains unclear. - Source: PubMed
Publication date: 2026/04/07
Ulanowicz Cassidy JAlarcon Pablo CDamen Michelle S M AWayland Jennifer LSawada KeisukeEom JohnStankiewicz Traci EChung HakLampe KristinSzabo SaraMoreno-Fernandez Maria ESalomonis NathanDivanovic Senad - Immune ageing impairs adaptive and innate responses, yet the spleen remains underexplored by cross-cohort single-cell studies. We profiled splenocytes from young, old and chronically stressed old mice with natural microbiota using single-cell RNA sequencing. Ageing was characterised by reduced lymphocyte competence and elevated stress responses. Within Gzmk CD8 T cells, young mice were enriched for Gzmk-high cells, whereas in old mice, both Gzmk-high and Gzmk-low cells showed greater heterogeneity and functional alterations: exhaustion in Gzmk-high and inflammation in Gzmk-low cells. Natural killer (NK) cells and macrophages exhibited reduced cytotoxic potential and sustained pro-inflammatory polarisation, respectively. Chronic stress caused modest compositional shifts that partially counteracted age-related changes. Furthermore, we integrated our dataset with six published datasets to build a comprehensive atlas with > 272,000 splenocytes. Atlas-level annotation showed reproducible compositional shifts across datasets. Conserved ageing signatures included loss of NK effector genes (Zeb2, Prf1), decline of naïve T quiescence (Lef1, Il7r) with stress induction (Rbm3, Socs3), gain of survival/pro-inflammatory/exhaustion genes (Bcl2, S100a6, Ccl5, Lag3) in effector T cells, and altered differentiation and regulation (Zbtb32, Zbtb20, Zfp318, Ighd, Cr2) in B cells. Our results define conserved features of splenic immunosenescence and provide an atlas for dissecting splenic immune alterations. - Source: PubMed
Philip Chinna SusanFilippov IgorHaljasorg UkuPeterson Pärt - In the tumor microenvironment (TME), "exhausted" CD8+ T cells are classified into progenitor (Tpex) and terminally exhausted (Ttex) populations. Tpex cells, critically regulated by zinc finger and BTB domain containing 27 (Zbtb27)/Bcl6 transcription factor, could be reinvigorated during immune checkpoint blockade (ICB) therapy, while Ttex cells, characterized by stronger proliferation and cytotoxicity, play an indispensable role in tumor control. However, the mechanisms governing the differentiation into Ttex and their function remain not well understood. In this study, we identified that Zbtb32, highly expressed in CD8+ Ttex subset, is crucial for CD8+ T cells within tumors. Zbtb32, regulated by CD28 signaling, promotes the differentiation of CD8+ T cells into Ttex subset, enhancing their cytotoxicity, proliferation, and anti-tumor capability. Importantly, we found a competitive DNA binding between Zbtb32 and Bcl6, especially in regulation of Id2 expression. Thus, our findings demonstrate the pivotal role of Zbtb32 in CD8+ T cell anti-tumor function, with implications in cancer immunotherapy. - Source: PubMed
Publication date: 2026/02/06
Pan BiruiSun QinliLi RuifengFeng JuanHao JingXie BowenZhao XiaohongZhao ZixuanWei PengLan QiuyanXie ShiyuanXie TianChen YongzhenWei KunZhong XuanQi HaiNi LingDong Chen - This study aimed to investigate the causal relationship between diabetes mellitus and pathological scarring, including hypertrophic scars (HS) and keloids, and to elucidate the underlying immune cellular mechanisms and key molecular regulators. - Source: PubMed
Publication date: 2026/01/19
Zhu GehuaXu JiaminGuo GuanghuaZhu Feng - The goal of this study was to investigate the immunological characteristics and potential clinical significance of B-cell subsets during different phases of hepatitis B virus (HBV) infection. - Source: PubMed
Publication date: 2025/06/09
Li JingChen SiyuanZhen ChengFan PeiyaoTang LiliZhang YangWang Fu-ShengZhang Chao