Ask about this productRelated genes to: HSPA4 Blocking Peptide
- Gene:
- HSPA4 NIH gene
- Name:
- heat shock protein family A (Hsp70) member 4
- Previous symbol:
- -
- Synonyms:
- HS24/P52, HSPH2
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-26
- Date modifiied:
- 2015-11-19
Related products to: HSPA4 Blocking Peptide
Related articles to: HSPA4 Blocking Peptide
- γ-Tocotrienol (γ-T3), a naturally occurring vitamin E isoform from plant-derived sources, has attracted attention as an antitumour agent. However, whether γ-T3 can enhance antitumour immunity and improve immune checkpoint blockade remains unclear. Here, using colorectal cancer (CRC) models, we found that γ-T3 suppressed tumour growth in immunocompetent MC38 and CT26 mouse models, whereas this effect was markedly weakened in immunodeficient hosts, indicating that its in vivo antitumour activity is closely associated with host immunity. Combination treatment with γ-T3 and programmed cell death protein 1 (PD-1) blockade further improved tumour control, accompanied by enhanced CD8 T cell effector function, reduced regulatory T cell abundance, and tumour-associated macrophage remodelling towards an antitumour phenotype. Immune cell depletion experiments confirmed that CD8 T cells are the principal effector cells mediating γ-T3-associated tumour suppression. Mechanistically, HSPA4 was identified as a candidate γ-T3-associated protein potentially linked to MHC-I-related immune-recognition features. γ-T3 promoted the expression of Psmb8 and Tap2 and increased MHC-I surface levels on tumour cells, accompanied by increased sensitivity of tumour cells to activated CD8 T cell-mediated growth inhibition. These findings support γ-T3 as a naturally derived immune-sensitising agent for improving PD-1 blockade therapy in CRC. - Source: PubMed
Publication date: 2026/06/30
Wang HaixiaChu XiaoheXu CanLi ZilongXie Ling - Breast cancer (BC) is the leading cause of cancer-related mortality in women. Atrazine, a prevalent herbicide, is a persistent environmental pollutant with bioaccumulative potential. This study investigated the potential mechanisms underlying the association between atrazine exposure and BC. - Source: PubMed
Publication date: 2026/07/17
Zhao ZitongCai YifanLi ChaofanDu ChongZhang Shuqun - The significant temperature variations across northern and southern China have driven the adaptive evolution of Chinese native cattle breeds, allowing them to thrive in diverse and extreme bioclimate environments. Understanding how these breeds have adapted to varying temperatures is essential for identifying genetic factors that contribute to their survival in such conditions. - Source: PubMed
Publication date: 2026/07/01
Zhao ChanghengTeng JunChen YanYang ChengZhang XinyiNing ChaoWang HuiliYang QienLv WenfaWang DanZhang Qin - Prenatal e-cigarette (e-cig) exposure has been associated with adverse cardiovascular outcomes in offspring, yet the underlying molecular mechanisms remain poorly understood. Using a rat model of gestational e-cig aerosol exposure combined with quantitative LC-MS/MS proteomics and integrated KEGG, Gene Ontology (GO), protein-protein interaction (PPI), and EggNOG analyses, we identified profound and sexually dimorphic alterations in the neonatal cardiac proteome. There was extensive mitochondrial and metabolic dysregulation in the developing heart following prenatal e-cig exposure. In male offspring, enriched pathways included oxidative phosphorylation, tricarboxylic acid (TCA) cycle activity, and respiratory chain assembly, indicating disruption of mitochondrial energy metabolism. In contrast, female offspring exhibited prominent dysregulation of mitochondrial chaperones (Hspa9, Hspa4) and ribosomal proteins (Rps11, Rpl11, Rps3), suggesting impaired proteostasis and translational capacity. PPI and KEGG analyses further revealed sex-dependent perturbations of signaling and structural protein networks critical for cardiac contractility, cardiomyopathy progression, and myocardial stress resilience. Males primarily showed alterations in sarcomeric, structural, and metabolic proteins, whereas females exhibited widespread disruption of GPCR/cAMP/PKA-mediated regulatory pathways. These early-life proteomic alterations translated into functional deficits in adulthood, with males displaying impaired baseline cardiac function and exacerbated ischemia/reperfusion (I/R) injury, while females showed preserved baseline function but heightened susceptibility to I/R stress. Collectively, these findings demonstrate that prenatal e-cig exposure programs long-lasting, sex-specific cardiac vulnerability through early-life proteomic reorganization, providing mechanistic insight into developmental cardiotoxicity and informing risk assessment during pregnancy. - Source: PubMed
Publication date: 2026/06/16
Tu JiazichaoJian JieLi YongChavez JacobZhang QuanqingYu RongjunYu WansuZhang LuboXiao Daliao - Platelets, a crucial source of liquid biopsy samples, play a significant role in the progression of various malignancies, including non-small cell lung cancer (NSCLC). However, specific biomarkers for early-stage NSCLC have not yet been identified. In this study, we employed bioinformatics approaches to identify differentially expressed genes (DEGs) in tumor-educated platelets (TEPs) from NSCLC. Subsequently, we validated these genes using specimens from patients with early-stage lung cancer, highlighting their potential as biomarkers for NSCLC. - Source: PubMed
Publication date: 2026/06/08
Xu ZhenLi WenxinYu YuenengWu HuifangZhang Lin