Ask about this productRelated genes to: NDST3 Blocking Peptide
- Gene:
- NDST3 NIH gene
- Name:
- N-deacetylase and N-sulfotransferase 3
- Previous symbol:
- -
- Synonyms:
- HSST3
- Chromosome:
- 4q26
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-22
- Date modifiied:
- 2016-07-05
Related products to: NDST3 Blocking Peptide
Related articles to: NDST3 Blocking Peptide
- Impairment of lysosomal acidification has recently been identified as a critical driver of amyloid-β and MAPT/tau pathology in Alzheimer's disease (AD). Restoring lysosomal acidification is a promising strategy for AD treatment. N-deacetylase and N-sulfotransferase 3 (NDST3) is a newly discovered tubulin deacetylase that regulates lysosomal acidification by influencing the recruitment of V-ATPase V1 subunits to lysosomes. Nevertheless, the role of NDST3 in AD remains entirely unexplored. - Source: PubMed
Publication date: 2026/04/21
Ge ChuanhuaWang KunTang HuiyuanKe YilingWang HuaiFu QiangXiu YunGuo YongzhengJia Yun-FangLong ZhiminHe GuiqiongTang Qing - Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis. Abnormal energy metabolism is a well-recognized cancer hallmark, yet the role of energy metabolism-related genes (EMRGs) in AML remains unclear. Thus, this study aims to identify such hub genes in AML and explore their prognostic significance, related pathways, and therapeutic targeting potential. - Source: PubMed
Publication date: 2026/03/02
Chen YiJi YueruQin WeiweiYan Xueqian - Acute myeloid leukemia (AML), a biologically heterogeneous malignancy, requires improved prognostic models, particularly for patients with intermediate-risk profiles and lacking definitive genetic markers. Therefore, this study aims to identify biologically coherent and clinically informative gene signatures using a novel prognostic modeling approach integrating gene expression profiles with protein–protein interaction networks. - Source: PubMed
Publication date: 2025/12/03
Song Jong KeonKim HyeryHwang Sang-Hyun - Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disruption of cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor function in an animal model of PD. Following NDST3 administration, the DN and its associated circuits in the substantia nigra and striatum showed marked revitalization, accompanied by a considerable alleviation of PD-like motor deficits. Integrative single-cell and spatial RNA sequencing with CUT&RUN revealed that NDST3-driven reactivation of pathways is linked to neuronal survival, synaptic integrity, and steering of compromised cells toward a resilient phenotype. By recalibrating the epigenetic landscape, NDST3 promotes cellular maintenance and functional recovery in key motor circuits. These findings highlight NDST3's therapeutic potential as an epigenetic modulator of PD. These findings provide insights into the mechanisms underlying neuronal revitalization and highlight the potential of NDST3 as a novel agent for restoring brain function in neurodegenerative conditions. - Source: PubMed
Publication date: 2025/11/21
Chang YujungNa YongwooIm HyeonjooYang GaramYang SeungseonShim Hyun SooKim ChunggooKim GyeungYunPark Hyeok JuKim Hee YoungLee Seung EunLee WonwoongHa YoonPark SunghoKim JieunCho Won-YoungSun WoongKim Jong-SeoYoo Junsang - As a leading cause of cancer-related mortality, liver cancer was associated with metabolic dysregulation. We aimed to identify metabolism-related prognostic biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2025/09/24
Wang TaoruiLai ZijunTang ShengjunLin LehangZhang Mingjiao