Ask about this productRelated genes to: HNMT Blocking Peptide
- Gene:
- HNMT NIH gene
- Name:
- histamine N-methyltransferase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-04-18
- Date modifiied:
- 2015-08-25
Related products to: HNMT Blocking Peptide
Related articles to: HNMT Blocking Peptide
- Multisite chronic pain (MCP) frequently co-occurs with immune and depressive disorders, yet whether it reflects coordinated cross-domain multi-omic dysregulation remains unknown. Using UK Biobank data (19,484 baseline participants; 32,870 to 399,476 for 15.9-year follow-up), we identified MCP-related multi-omic signatures spanning 59 biochemical measures, 168 metabolites, and 2,920 proteins. Notably, these signatures showed graded dysregulation [controls < depression < rheumatoid arthritis (RA) < comorbidity] with increasing disease burden, were associated with increased risk of incident RA and depression, and partially mediated their bidirectional association. We further identified HNMT as a depression risk factor, FGF21 as an RA risk factor, MME as a depression protective factor, and platelet count/FGF21/HNMT as shared factors using Mendelian randomization. Beyond disease outcomes, the signatures were associated with brain structural impairment and health-related behaviors (smoking/fish intake/physical activity), and aligned with polygenic liability for immune-metabolic-psychiatric traits. Together, these findings demonstrate that MCP reflects coordinated neuro-immune-metabolic dysregulation underlying RA-depression comorbidity and functions as a systems-level phenotype linking immune processes and depression. - Source: PubMed
Publication date: 2026/06/17
Wang QianTian Ye EllaZalesky AndrewWang PengFu ZeningFeng GuozhengZhi DongmeiXu MingWang ChunyangWang XiaoliWang XizhenQin PeiwuCalhoun Vince DJiang RongtaoSui Jing - Epithelial barrier disruption is a hallmark of allergic skin diseases. Sodium dodecyl sulfate (SDS), a surfactant in household cleaning products, is known to impair the barrier. - Source: PubMed
Publication date: 2026/05/17
Li ManruBabayev HuseynD'Avino PaoloZeyneloğlu CanBicer CerenYazici DuyguPat YagizSvedenhag PerGaudenzio NicolasAkdis Cezmi AMitamura Yasutaka - The histaminergic pathway has been implicated in Parkinson's disease (PD). Histamine is metabolized by histamine N-methyltransferase (HNMT), and the gene encoding this enzyme has a C314T polymorphism, in which cytosine is replaced by thymine. This results in reduced enzymatic activity. To analyze the C314T polymorphism of the HNMT gene in Mexican patients with idiopathic PD. In this study, peripheral blood samples were collected from patients with PD and healthy controls for genomic DNA extraction. HNMT genotyping was performed using the restriction fragment length polymorphism (RFLP) technique. Quantitative variables were compared using Student's test, and categorical variables were compared using Pearson's χ test. The risk of PD was estimated using odds ratios (ORs) and 95% confidence intervals (CIs). According to the results of the bivariate analysis, compared with the controls, the patients were significantly older ( = 0.001) and had a higher incidence of hypertension ( = 0.020). HNMT RFLP analysis suggested an association between the C allele and PD development, with an OR (95% CI) of 7.424 (0.866-63.646). In contrast, the T allele appeared to confer a protective effect, with an OR of 0.134. In the age-adjusted Mantel-Haenszel stratified analysis of the HNMT C314T polymorphism, the C allele was identified as a risk factor for PD development in this small cohort, with an OR (95% CI) of 12.0 (0.8-160.4; = 0.041). Advanced age, hypertension, and the C allele of the HNMT gene were associated with an increased risk of PD, whereas the T allele appeared to be associated with a protective role. - Source: PubMed
Publication date: 2026/04/09
Bueno-Nava AntonioDíaz-Hernández Diana-KarinaPaniagua-Pérez RogelioCarrillo-Mora PaulMartínez-Cortez José-AntonioHernández-Arenas ClaudiaLeón-Hernández Saúl-RenánOlmos-Hernández AdrianaVerduzco-Mendoza AntonioAvila-Luna AlbertoGálvez-Rosas Arturo - - Source: PubMed
Publication date: 2026/05/03
Chen HangChen YifuZang ShihuiChen XueruiXiao Junjie - Chickens are a primary source of protein in the human diet, with demand increasing annually. However, research on genes that promote chicken meat development remains relatively limited. Therefore, in this study, breast muscle samples (pectoralis major, = 10 per group) from chickens at five developmental stages (D1, D35, D70, D105, and D140) were selected to investigate genetic-level changes and identify additional genes influencing chicken meat development. Differential expression analysis between adjacent stages (|FC| > 1.5, < 0.05) revealed 42 differentially expressed genes (DEGs) shared across four comparisons, primarily enriched in muscle development pathways such as focal adhesion, the regulation of the actin cytoskeleton, and Wnt signaling. Weighted gene coexpression network analysis (WGCNA) revealed that four modules were significantly correlated with body weight and breast muscle weight phenotypes. By integrating the hub genes of the four modules and the DEGs, we identified key genes, including , , , , , and . Furthermore, we conducted a comparative analysis of key gene expression trends across commercial broilers (CBs) and Beijing You (BJY) chickens. and exhibited distinct expression patterns during the early developmental stage of Xianju (XJ) chickens, suggesting that these genes may be critical factors distinguishing XJ chicken breast muscle development from that of other breeds. In all three chicken breeds analyzed, the expression levels of and gradually decreased with increasing age, indicating that their functions are universal in poultry muscle development. In summary, our findings revealed key regulatory genes that influence breast muscle development, offering candidate targets for marker-assisted selection in poultry breeding programs. - Source: PubMed
Publication date: 2026/04/01
Jin YutingTan XiaodongLiu LuLi JiahuaDong JieHuang MinjieZhao AyongWang Deqian