Ask about this productRelated genes to: FBXO7 Blocking Peptide
- Gene:
- FBXO7 NIH gene
- Name:
- F-box protein 7
- Previous symbol:
- -
- Synonyms:
- FBX7, Fbx, PARK15
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-27
- Date modifiied:
- 2015-08-25
Related products to: FBXO7 Blocking Peptide
Related articles to: FBXO7 Blocking Peptide
- FBXO7 and PI31 variants are linked to rare Parkinsonian syndromes, implicating their dysfunction in neurodegeneration. We define how both engage each other and regulate the proteasome 20S core particle (CP). In cells, each can associate independently with the proteasome, with multiple domains in FBXO7 contributing. Utilizing cryo-EM we visualized how FBXO7's C-terminal domain engages multiple subunits within the CP interior, blocking the β5 peptidase activity. In contrast, we visualized PI31 engagement of all three catalytic sites within the 20S CP, revealing the previously unknown structural basis for β1 inhibition. Furthermore, we establish how disease-associated variants impact both FBXO7 and PI31 function, including disruption of proteasome inhibition and SKP1-FBXO7-PI31 complex assembly. These results establish an unexpected function for FBXO7, providing a mechanistic basis for investigation of its role in proteasome regulation in Parkinson's disease. - Source: PubMed
Publication date: 2026/06/04
Adolf FrankGoodall Ellen ASingh Ekampreetvon Gronau SusannePerez Erignacio FerminFung DarleneMüller BenediktPaulo Joao AHanna JohnHarper J WadeSchulman Brenda A - - Source: PubMed
Publication date: 2026/06/05
Kesarwani SuchismitaMustafa FarsanaKaur RanjotAgarwal AyushTripathi MadhaviSrivastava Achal KumarGarg Divyani - Osteoarthritis (OA) is a chronic degenerative disease marked by cartilage destruction and subchondral bone remodeling, resulting in functional disability and pain. FBXO7 has been implicated in various inflammatory conditions; however, its functional and molecular participation in OA development and progression remains largely unexplored. This study investigated FBXO7's protective function in cartilage homeostasis and its underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/05/08
Huang ZhuSongGuo HuilingLin XuChaoLan JinFuZhao WenHanChen Min - - Source: PubMed
Publication date: 2026/04/16
Al Rawi SaraTyers PamelaBarker Roger ALaman Heike - Coexisting myocardial infarction (MI) and type 2 diabetes mellitus (T2DM) is a common condition. We aimed to investigate the association between MI and type 2 diabetes (T2D) with mitophagy-related differentially expressed genes (MRDEGs) and the impact thereof on disease progression. - Source: PubMed
Publication date: 2026/04/08
Yang YingWan FeiyanXu XuelianXu WeiJiang LingliPan Pei