Ask about this productRelated genes to: RCAN3 Blocking Peptide
- Gene:
- RCAN3 NIH gene
- Name:
- RCAN family member 3
- Previous symbol:
- DSCR1L2
- Synonyms:
- -
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-26
- Date modifiied:
- 2015-02-02
Related products to: RCAN3 Blocking Peptide
Related articles to: RCAN3 Blocking Peptide
- Plasma circular RNAs (circRNAs) are stable RNA molecules found in blood, which makes them potential noninvasive biomarkers for acute myocardial infarction (MI). The aim of this study was to describe the plasma circRNA profile in patients with acute MI and to identify circRNA markers that may help detect heart injury and reflect the biological processes involved. We compared plasma samples from patients with acute MI and healthy controls using total RNA sequencing with unique molecular identifiers (UMIs). After sequencing, reads were processed through quality control, alignment, duplicate removal, and circRNA detection. Differential expression was analyzed after adjusting for age, sex, smoking, and technical factors. Several circRNAs were significantly different between MI cases and controls and were able to separate the two groups in principal component and receiver operating characteristic analyses. Among the most increased circRNAs were hsa-PASK_0004, hsa-STXBP3_0002, hsa-RCAN3_0002, and hsa-RANBP9_0044, while hsa-HIF1A_0002, hsa-SUZ12_0049, hsa-PNRC1_0001, and hsa-RAB2A_0002 were decreased. Several candidates showed AUC values above 0.7. Pathway analysis linked the host genes of these circRNAs to inflammation, platelet activation, coagulation, and cardiomyocyte stress responses. Overall, these findings suggest that circulating circRNAs may serve as useful blood-based markers of MI and provide insight into the molecular changes that accompany acute MI. - Source: PubMed
Publication date: 2026/04/14
Alali RudaynahAlqannas Naif KhalidHabara Alawi HAlmansori MohammedAlsaeed AliVatte ChittibabuCyrus CyrilAlqatari Safi GAlbisher HassanAl-Ajwad Mustafa HAlshahrani Faisal SAlmuslim Moyad MVenø Morten TKeating Brendan JAl-Ali Amein K - Pancreatic cancer remains highly lethal, largely due to late diagnosis and limited efficacy of treatments. Improving first-line treatment selection and patient monitoring requires novel, non-invasive biomarkers beyond carbohydrate antigen 19-9 (CA19-9) and imaging. This study investigates epigenetic biomarkers from liquid biopsy with prognostic and predictive potential in metastatic pancreatic ductal adenocarcinoma (PDAC; mPDAC). Genome-wide methylation profiling of cell-free DNA (cfDNA) from healthy individuals and stage IV mPDAC patients identified 13 gene-associated CpG sites with significantly altered methylation patterns. ddPCR validation confirmed consistent methylation differences in lymphocyte transmembrane adaptor 1 (), nuclear receptor subfamily 3 group C member 1 (), and between healthy and patient groups. Elevated and methylation and reduced methylation at diagnosis were associated with poor prognosis and correlated with high-risk circulating biomarker profiles, including CA19-9 levels, MAF (mutant allele fraction), cfDNA concentration, and cfDNA fragmentation. Notably, baseline methylation levels predicted response to first-line FOLFIRINOX-based treatment with an acceptable 75% sensitivity and a high specificity of 92.86%. These findings highlight the clinical significance of cfDNA methylation as a minimally invasive biomarker source, emphasizing , , and as prognostic biomarkers in mPDAC. Specifically, baseline methylation emerges as a promising predictor of treatment response, supporting personalized therapeutic strategies in mPDAC. - Source: PubMed
Publication date: 2026/03/22
Cano-Ramírez PabloToledano-Fonseca MartaCano-Osuna María TeresaHerrera-Casanova NereaCarrillo-Pecero EmilioRodríguez-Ariza AntonioAranda EnriqueGarcía-Ortiz María Victoria - Domestic chickens primarily descended from the wild red junglefowl, play a crucial role in global egg and meat production. China hosts diverse indigenous chicken populations that have adapted to various environmental conditions, including high-altitude with hypoxic and ultraviolet radiation stress. - Source: PubMed
Publication date: 2025/12/22
Bello Semiu FolaniyiTerefe EndashawYe HaoqiangAdeola Adeniyi CharlesZhou ZhenJebessa EndashawQi LinAhmed Ridwan OlawaleAloryi Kelvin DodziOsitanwosu Obiajulu EmenikeEludodun Sunday JamesZhang ZhaofengTiamiyu Bashir BolajiLadejobi Afusat KikelomoAhbara Abulgasim MSalim BashirRothenberg Dylan O'NeillAdigun Oludoyin AdeseunZhang XiquanCai BolinHanotte OlivierNie Qinghua - Sepsis, a life-threatening dysregulated immune response to infection, has a high global mortality rate. Tregs play dual roles in sepsis pathogenesis, with their expansion linked to immunosuppression. This study explores Treg dynamics and the novel role of CD82 in sepsis. - Source: PubMed
Publication date: 2025/08/27
Zhu GuangyanLiao YanlinLiu SiminLiu PingYang KaiTan MingheYi LishaZhang DingyuXia Haifa - Giant cell arteritis (GCA) is an autoimmune disease affecting medium and large arteries. It varies in presentation and often recurs, potentially leading to blindness and aneurysms. The pathogenesis of GCA is not well understood. This study aimed to identify key genes linked to GCA and explore potential pathogenic mechanisms. - Source: PubMed
Publication date: 2025/05/09
Cheng TaoChen JiafanShan XinjueJia BochaoSang SulinWang YunkaiWei YiHu Yuanhui