Ask about this productRelated genes to: RORA Blocking Peptide
- Gene:
- RORA NIH gene
- Name:
- RAR related orphan receptor A
- Previous symbol:
- -
- Synonyms:
- RZRA, ROR1, ROR2, ROR3, NR1F1
- Chromosome:
- 15q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-04-13
- Date modifiied:
- 2016-10-05
Related products to: RORA Blocking Peptide
Related articles to: RORA Blocking Peptide
- Osteoarthritis (OA) is the most common degenerative joint disease. Recent evidence has shown that retinoic acid-related orphan nuclear receptor alpha (RORα) plays an important role in OA pathogenesis. However, its downstream regulatory mechanisms remain to be elucidated. Alterations in chondrocyte extracellular matrix (ECM) metabolism were observed by overexpressing or knocking down RORα in OA chondrocyte models. The OA mouse model was induced by unstable medial meniscus surgery (DMM), and the RORα inhibitor SR3335 or AAV virus was injected intra-articularly into the mice. Furthermore, Col2a1-creERT2: RORα (RORα-KO) inducible conditional knockout mice were generated to elucidate the role of RORα in OA. Moreover, mRNA sequencing was conducted to identify potential downstream regulatory mechanisms of RORα. The overexpression of RORα in chondrocytes induced ECM degradation in mouse chondrocytes and accelerated cartilage degeneration in mice. In contrast, treatment with SR3335 or knockdown of RORα in chondrocytes alleviated ECM degradation. Similarly, less cartilage degeneration was observed in intra-articular injections of SR3335 and in the RORα-KO mice. Mechanistically, cartilage degeneration was promoted by RORα through the activation of the Wnt/β-catenin pathway and the facilitation of the nuclear translocation of β-catenin. Notably, the Wnt/β-catenin pathway inhibitor XAV-939 ameliorated RORα-induced ECM degradation in chondrocytes. The expression of RORα is increased in OA, triggering an imbalance in cartilage ECM metabolism, which leads to cartilage degeneration. Notably, the Wnt/β-catenin signaling pathway plays a critical role in RORα-mediated regulation of ECM degradation in chondrocytes. In summary, the RORα-Wnt/β-catenin pathway axis is pivotal in the pathogenesis of OA. - Source: PubMed
Zhu RuijueHe TianweiDi JiaweiMai LangWu DepengHuang MudanLiu YankuiLiu ZhongyuZhang LiangmingHe Lei - Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal neuronal electrical activity. Increasing evidence suggests that circadian clock dysfunction contributes to seizure susceptibility and neuronal excitability. Melatonin, a major regulator of circadian rhythm, possesses antioxidant and neuroprotective properties that may influence seizure regulation. Cucurbitacin E (CuE), a triterpenoid compound with potent antioxidant and anti-inflammatory activities, has emerged as a potential therapeutic agent targeting circadian and oxidative pathways. This study investigated the effects of CuE on seizure activity, oxidative balance, melatonin levels, and circadian clock gene expression in a pentylenetetrazol (PTZ)-induced epilepsy model. - Source: PubMed
Publication date: 2026/05/27
Sarıcı Sinem BebekOvayolu ÖzlemYılmaz Şenay Görücü - Retinoic acid receptor-related orphan receptor-α (RORα), a nuclear receptor transcription factor, is essential for maintaining organismal homeostasis and regulating diverse physio-pathological processes. However, its emerging role as a molecular nexus that integrates cholesterol metabolism with macrophage polarization to promote metabolic inflammation has not been systematically summarized. Cholesterol synthesis, transport, and efflux are critical for macrophage polarization. RORα regulates key components of these metabolic pathways and the associated transcriptional mechanisms driving polarization. Moreover, RORα regulates various other immune cells, such as T cells and microglia. This review aims to elucidate the core mechanisms of RORα in the crosstalk between cholesterol metabolism and inflammation, providing a novel method for therapeutic strategies. - Source: PubMed
Publication date: 2026/05/08
Li DengjuLiu GuangxianWen XiangdongZhang GuojiangLiu KaixuanYuan LinYu BingbingAn Senbo - Age-related cataract (ARC) is a severe vision-impairing disorder primarily caused by oxidative stress-induced senescence and apoptosis of lens epithelial cells (LECs). In this study, a sodium selenite-induced oxidative stress cataract model in neonatal rats was established to simulate the pathological progression of ARC. We found that retinoic acid receptor-related orphan receptor α (RORA) exacerbates cellular senescence and oxidative damage by targeting prion protein (PRNP), and its small-molecule inhibitor SR3335 exhibits therapeutic potential in regulating ARC progression. In vitro experiments showed that inhibiting RORA significantly alleviated cellular senescence, enhanced the anti-apoptotic capacity of LECs, and improved their resistance to oxidative stress, whereas activating RORA exerted opposite effects. In vivo, intravitreal injection of recombinant PRNP protein was demonstrated to abrogate the protective effect of RORA silencing, thereby exacerbating the progression of ARC. Mechanistically, RNA sequencing and dual-luciferase reporter assay revealed that RORA binds to its downstream target PRNP. RORA targets PRNP to regulate the p53/p21/Bax signaling pathway, thereby suppressing both cellular senescence and apoptosis. These findings highlight the critical role of the transcription factor RORA in ARC development by modulating oxidative stress injury, apoptosis, and senescence in LECs. The identification of PRNP as a downstream target of RORA may provide a novel dual-target strategy for ARC treatment. - Source: PubMed
Zou YueLi WanqianZhang JiaojiaoCen ChaoZheng WanqiuLi RuonanCheng HongLiang LiangKang JuanWan WenjuanHu KeZheng Shijie - Sepsis-induced immunosuppression is a key factor contributing to high mortality rates. However, suitable biomarkers for routine clinical monitoring of immune function are currently lacking. Serum cholinesterase levels are markedly diminished in sepsis and are associated with unfavorable prognoses, its role in the immunosuppression pathology and the mechanisms involved remain inadequately understood. - Source: PubMed
Publication date: 2026/05/07
He QianHuang Xu