Ask about this productRelated genes to: RORA Blocking Peptide
- Gene:
- RORA NIH gene
- Name:
- RAR related orphan receptor A
- Previous symbol:
- -
- Synonyms:
- RZRA, ROR1, ROR2, ROR3, NR1F1
- Chromosome:
- 15q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-04-13
- Date modifiied:
- 2016-10-05
Related products to: RORA Blocking Peptide
Related articles to: RORA Blocking Peptide
- Retinal pigment epithelial and outer retinal atrophy (RORA) and complete RORA (cRORA) are major determinants of long-term vision in neovascular age-related macular degeneration (nAMD), but their development across subtypes is poorly defined, especially in Asian populations, in whom pachychoroid-driven disease is common. We compared long-term visual outcomes and atrophy burden between the conventional and novel nAMD classifications. - Source: PubMed
Publication date: 2026/08/24
Hazra DebabrataTomita YoheiUchida AtsuroKato SoshiNagai NorihiroSuzuki MisaMinami SakikoKunimi HiromitsuBan NorimitsuKurihara ToshihideShinoda HajimeOzawa YokoNegishi Kazuno - To characterize and quantify optical coherence tomography (OCT) hyperreflective choroidal foci (HCF) in geographic atrophy (GA) of age-related macular degeneration (AMD) and to assess their distribution across different GA phenotypes. - Source: PubMed
Pilotto ElisabettaParolini FedericoEdwards Malia MMidena EdoardoMidena Giulia - Periodontitis is a chronic inflammatory condition linked to systemic diseases, yet the neuroendocrine mechanisms underlying its pathogenesis remain unclear. This study aimed to elucidate neuroendocrine-related molecular pathways involved in periodontitis. Transcriptomic data and neuroendocrine-related genes (NRGs) were integrated to identify candidate genes from the overlap between differentially expressed genes (DEGs) and NRGs. Machine learning, ROC analysis and expression validation were used to screen key genes and construct a diagnostic nomogram. Functional enrichment, immune infiltration, drug prediction, molecular docking and single-cell analyses were performed. Key gene expression was further validated using clinical samples. Nine candidate genes were obtained from the intersection of 210 DEGs and 1441 NRGs. Five key genes-FOXN1, XBP1, HCLS1, IRF4 and RORA-were identified and used to develop an effective diagnostic model. These genes showed distinct tissue and cellular distributions and were enriched in pathways such as Ribosome and Protein processing in the ER. Sixteen immune cell types differed between groups, and 24 potential drugs, including melatonin, were predicted. Single-cell analysis highlighted T cells and Endothelial cells as central cell populations. PCR results aligned with bioinformatic findings. Five neuroendocrine-related genes were identified as potential diagnostic biomarkers and therapeutic targets, offering new insights into the neuroendocrine mechanisms of periodontitis. - Source: PubMed
Zhang JiaguanLiu ZiyanDeng JianqingHuang PeishanLiu Huijuan - DNA methylation (DNAm) may link environmental exposures to pain susceptibility. We examined preoperative DNAm patterns (using next-generation enzymatic-methylation sequencing) associated with chronic postsurgical pain (CPSP), a major biopsychosocial problem in adolescents undergoing musculoskeletal surgeries, recruited across six sites ( = 166; 15.5 (IQR 14.3-16.8) years; 51% male). Pain and functional measures were followed longitudinally. CPSP was defined as pain>3/10 beyond two months post-surgery. We identified 289 differentially methylated loci (DML; HB < 0.1) that satisfied robustness criteria after bootstrapping, and 20 regions (DMR) (FDR < 0.05) associated with CPSP. Using CPSP-specific background, DMLs, annotated to 57 genes, were enriched for biological processes (Cellular response to cAMP ( = 0.001), neuronal action potential ( = 0.01), sodium ion transmembrane transport ( = 0.03), potassium ion transmembrane transport ( = 0.035) and regulation of postsynaptic membrane potential ( = 0.041)), molecular functions (Intracellular camp-activated cation channel activity ( = 0.001), cAMP binding ( = 0.003), voltage-gated sodium channel activity ( = 0.01), and voltage-gated potassium channel activity ( = 0.02)), and cellular components (HCN channel complex ( = 0.002), presynaptic active zone membrane ( = 0.006), and postsynaptic membrane ( = 0.049)). DMRs did not enrich gene pathways but showed transcription factor motif enrichment for stress response (TGF-β/SMAD), neuronal differentiation/plasticity (NR4A/TEAD), inflammation/immunity (STATs), and circadian signaling (RORA/RORB/NPAS2). Study findings suggest potential DNAm signatures associated with CPSP and generate hypotheses regarding their possible role in CPSP development. - Source: PubMed
Publication date: 2026/08/01
Vijayarajan Siva Athitya LakshamanaKrolick Kristen NZhang XueMartin Lisa JGlynn SusanCole KristiGarcia VictorJi HongRamamurthi R JEinhorn L MMonitto C LGanesh AChidambaran Vidya - Sleep disturbance is prevalent in aging populations, yet its association with ambient PM remains insufficiently characterized due to the lack of reliable molecular biomarkers. We leveraged 2350 middle-aged and older adults from the Guangxi Eco-Environmental Health and Aging Study to examine the association between PM exposure and sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) and to identify relevant DNA methylation signatures of circadian rhythm genes. Higher PM was significantly associated with worse sleep outcomes, with the strongest associations for the 2-month exposure window. Particularly, per 10 μg/m increase in the 2-month average PM was associated with a 1.33-point increase in PSQI score (95% CI: 0.95, 1.71), a 0.79-hour reduction in sleep duration (95% CI: -0.99, -0.59), and higher odds of poor sleep quality (odds ratio [OR] =2.17, 95% CI: 1.69, 2.80) and abnormal sleep duration (OR =1.59, 95% CI: 1.24, 2.03). A two-stage analysis of DNA methylation signatures identified 47 sleep-related CpG sites, of which 11 were selected using LASSO penalization to construct the sleep-quality-related methylation risk score (MRS). Mediation analyses further identified five CpGs annotated to NPAS2, PRKAG2, RORA, and CSNK2A2 that partially mediated the association between PM exposure and sleep quality (mediation proportions: 9.08%-15.98%), whereas the sleep MRS accounted for a higher mediation proportion than individual CpGs (25.03%). Our findings underscore ambient PM exposure as a relevant environmental factor linked to impaired sleep quality and highlight that circadian epigenetic signatures could serve as molecular markers of vulnerability to pollution-related sleep disturbances. - Source: PubMed
Publication date: 2026/07/28
Wang YutingLiu ShuzhenRong JiahuiLuo YaxinNiu SiyuanGuo PeifengTang XuLiang YujianMo XiaotingZhao LinhaiJiang ShiwenGu TiantianLi YouPang WeiyiYeung Shiu Lun AuQin JianZhang ZhiyongCai JianshengGao Xu