Ask about this productRelated genes to: RABGGTB Blocking Peptide
- Gene:
- RABGGTB NIH gene
- Name:
- Rab geranylgeranyltransferase subunit beta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-14
- Date modifiied:
- 2018-04-23
Related products to: RABGGTB Blocking Peptide
Related articles to: RABGGTB Blocking Peptide
- Breast cancer (BC) is the most common malignancy among women worldwide. Although observational studies have linked carnitine-related metabolites (CRMs) to BC, causal inference has been limited by confounding and reverse causality. This study used Mendelian randomization (MR) analysis to investigate the potential causal link between CRMs and BC. - Source: PubMed
Publication date: 2026/04/03
Ran FeifengQue LilinLuo LanGan MeiWang RenshengLiang Leifeng - Statins (HMG-CoA reductase inhibitors) are associated with myopathy, yet the precise in vivo mechanisms underlying this association remain unclear. Emerging evidence implicates a deficiency of geranylgeranyl pyrophosphate (GGPP), a key downstream isoprenoid metabolite of the mevalonate pathway. We employed novel muscle-specific genetic mouse models to elucidate the roles of GGPP and Rab geranylgeranyl transferase β (RabGGT-β) in the development of myopathy. - Source: PubMed
Publication date: 2026/06/20
Osaki YoshinoriMizunoe YuheiNakagawa YoshimiMiyamoto TakafumiFujita RyoHan Song-IeeAraki MasayaTomoda MasatakaKainoh KentaOhno HiroshiIwasaki HitoshiMatsuzaka TakashiSone HirohitoOhashi KenIshibashi ShunSekiya MotohiroShimano Hitoshi - Bisphosphonates (BPs) are the most widely used anti-resorptive agents and first-line drugs for managing bone-related diseases, such as osteoporosis, Paget disease of bone, and bone metastatic cancer. BPs are known to inhibit osteoclasts' functions, and recent studies have highlighted the importance of macroautophagy/autophagy in osteoclasts. However, the involvement of autophagy in BP-mediated inhibition of osteoclast functions remains unclear. In this study, we showed that BPs inhibit the bone resorptive functions of osteoclasts by blocking autophagy. At the non-apoptotic doses, zoledronic acid (ZOL) inhibited autophagy by blocking autophagic flux and delaying the degradation of autophagy-related proteins. ZOL also prevented the cleavage and secretion of secretory proteins such as CTSK, ACP5/TRAP, and MMP9 essential for bone resorption. Mechanistically, ZOL inhibits the prenylation of the RAB7 small GTPase, a key protein that is required for autolysosome formation. studies showed that osteoclast-specific conditional knockout mice exhibited osteopetrotic phenotypes. These findings provide insights into how BPs disrupt osteoclast function by blocking autophagy and suggest that targeting autophagy in osteoclasts could be a potential therapeutic approach for bone-related diseases.: ACP5/TRAP: acid phosphatase 5, tartrate resistant, ATG: autophagy related, 54 BafA1: bafilomycin A1, BECN1: beclin 1, BMM: bone marrow-derived macrophage, CQ: 55 chloroquine, CSF1/M-CSF: colony stimulating factor 1, CTSK: cathepsin K, CTX-I: C-terminal 56 telopeptide of type I collagen, FPPS: farnesyl pyrophosphate synthase, GFP: green fluorescent 57 protein, GGTI: geranylgeranyltransferase I inhibitor, LAMP1: lysosome associated membrane 58 protein 1, MAP1LC3/LC3: microtubule associated protein 1 light chain 3, MMP9: matrix 59 metallopeptidase 9, N-BPs: nitrogen-containing bisphosphonates, P1NP: procollagen type I N- 60 terminal propeptide, PGGT1B: protein geranylgeranyl transferase type I subunit beta, RABGGTB: 61 Rab geranylgeranyltransferase subunit beta, RFP: red fluorescent protein, SQSTM1/p62: 62 sequestosome 1, TNFSF11/RANKL: TNF superfamily member 11, ZOL: zoledronic acid. - Source: PubMed
Publication date: 2026/06/28
Kim SolGoldshteyn VadimArai AtsushiBae Eun-BinWhitelegge JulianShin Ki-HyukPark No-HeeKim Reuben H - Protein prenylation is an important posttranslational modification being involved in several processes such as regulation of immune response. Here, we analyzed expression of four genes from this pathway, namely FNTA, RABGGTA, RABGGTB and PGGT1B in patients with neuromyelitis optica (NMO). Using the comparative ΔCt method (normalizing target gene expression to the housekeeping gene B2M), the study demonstrated that all four genes were significantly overexpressed in NMO patients compared to controls (p < 0.0001). When patients and controls were classified into high and low gene expression subgroups based on these cut-offs, an overwhelming majority of NMO patients fell into the high expression group for all four genes, whereas most healthy controls were categorized in the low expression group. All genes had appropriate performance in separation of NMO patients from controls with AUC values ranging from 0.89 to 0.97 for FNTA and RABGGTA, respectively. Altogether, the study demonstrates dysregulation of prenyltransferase-related genes in NMO and their possible application as peripheral markers. - Source: PubMed
Publication date: 2025/07/18
Taheri MohammadFeghahati Fatemeh SadatHussen Bashdar MahmudHesami OmidAbak AtefeGhafouri-Fard Soudeh - Post-translational prenylation of G proteins is implicated in physiological insulin secretion. It has been reported recently that GGTase-III participates in the functional regulation of Ykt6, a synaptobrevin homolog, geranylgeranylation. However, potential localization and putative regulatory roles of GGTase-III in insulin secretion remains unknown. The current study is aimed at determining the expression and contributory roles of GGTase-III in glucose- and KCl-induced insulin secretion from pancreatic β-cells. - Source: PubMed
Gleason Noah FHali MirabelaKowluru Anjaneyulu