Ask about this productRelated genes to: CHRNA5 Blocking Peptide
- Gene:
- CHRNA5 NIH gene
- Name:
- cholinergic receptor nicotinic alpha 5 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-11
- Date modifiied:
- 2016-10-05
Related products to: CHRNA5 Blocking Peptide
Related articles to: CHRNA5 Blocking Peptide
- Tobacco smoking is a leading cause of global mortality, with cessation being the primary prevention strategy. Nicotine addiction has a genetic component; the rs503464 single nucleotide polymorphism (SNP) in the gene is associated with smoking cessation therapy success. However, the impact of communicating genetic risk to patients remains unclear. This study evaluated whether knowledge of the rs503464 genotype influences smoking cessation rates. - Source: PubMed
Publication date: 2026/03/10
Colombo FrancescaVeronese ChiaraMunarini ElenaPaolino CinziaMaspero DavideMangano NunziaEsposito MartinaMinnai FrancescaNoci SaraGiussani MartaMorelli DanieleCardani ElisaEsposito AlessandroSacco Gaia Giulia AngelaSpitaleri DeboraBoffi Roberto - Addiction to nicotine and alcohol continues to be a leading cause of death and loss of productivity. Polymorphisms in have been identified as risk factors in human genetic studies. Whether the function is independently relevant to phenotypes associated with substance abuse and if genetic factors influence subsequent outcomes when exposure to psychoactive substances happens at an early age, are questions of interest. We generated a stable mutant line in zebrafish using the CRISPR-Cas9 technique. We found the -mutant fish exhibited an increased acute preference to both nicotine and alcohol in the self-administration zebrafish assay (SAZA). When subjected to multi-day exposures to either drug, mutants exhibited greater behavioral changes, but reduced transcriptomic changes compared with wild-type siblings, suggesting an impaired homeostatic regulation following drug exposure. mutants also exhibited drug-independent changes in appetite and circadian rhythms. We expect these results to give new insights into genetic predisposition that modulates vulnerability to nicotine and alcohol abuse. - Source: PubMed
Publication date: 2026/01/19
Goel TanishaRaine JoshuaKibat CarolineCollado Jeff WinxinBanerjee Tirtha DasMathuru Ajay S - Patients with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) tend to have more severe respiratory symptoms than those with asthma or COPD only. In this study, we sought to identify genetic variants associated with ACO. - Source: PubMed
Li HuashiNadkarni Girish NPowell Charles AKraft MonicaLi Xingnan - Pneumonia risk is influenced by demographics, chronic disease burden, lifestyle, and environmental factors. Despite previous genetic studies, the impact of host genetics on pneumonia, particularly within specific patient groups, remains unclear. - Source: PubMed
Publication date: 2026/01/23
Heikkilä AnniSliz EevaVäyrynen SaraReis KadriElnahas Abdelrahman GReigo AnuEsko Tõnu Kettunen JohannesHautala Timo - Lung cancer (LC) and heart failure (HF) frequently co-occur with substantial clinical consequences, yet their shared genetic architecture remains poorly characterized. Emerging evidence suggests common pathophysiological pathways may underlie this comorbidity, particularly involving neural signaling and inflammatory processes. - Source: PubMed
Publication date: 2026/01/12
Mu LinquanZhou YiLi SongpuLiu Feng