Ask about this productRelated genes to: ECH1 Blocking Peptide
- Gene:
- ECH1 NIH gene
- Name:
- enoyl-CoA hydratase 1
- Previous symbol:
- -
- Synonyms:
- HPXEL
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-04-26
- Date modifiied:
- 2016-10-05
Related products to: ECH1 Blocking Peptide
Related articles to: ECH1 Blocking Peptide
- Chromophobe renal cell carcinoma (ChRCC) is characterized by the accumulation of abnormal mitochondria, a high rate of mitochondrial DNA (mtDNA) mutations, and altered oxidative metabolism. There are no existing circulating biomarkers to distinguish metastatic ChRCC from clear cell renal cell carcinoma (ccRCC). - Source: PubMed
Publication date: 2026/03/23
Steiner ClaraHan TiegangSafi StevenBzeih WafaaMansour HadiSaad EddyWilliams Jessica FHirsch Michelle SGiri Vinay KAscione LilianaElon YehonatanDicker Adam PTang YanChoueiri Toni KHenske Elizabeth PXu Wenxin - Zearalenone, a mycotoxin commonly detected in food and the environment, is an underestimated global public health concern, especially as climate change may worsen its prevalence and effects. Although zearalenone has been associated with various adverse health outcomes, the exact mechanistic links to obesogenic effects, mitochondrial dysfunction, and related molecular pathways remain unclear. This research explored the impact of early-life zearalenone exposure on lipid accumulation and its potential relationship to mitochondrial dysfunction in the nematode Caenorhabditis elegans. Multiple lipid indicators, including Nile Red, Oil Red O, lipid droplet-associated fluorescent protein DHS-3, and triglyceride assays, showed that zearalenone exposure (0.3-50 μM) significantly increased worm lipid content. At 50 μM, zearalenone significantly upregulated lipogenesis genes (fasn-1, fat-6, fat-7, pod-2), β-oxidation genes (acs-2, ech-1), and transcription factors (nhr-49, sbp-1). Oil Red O assays using nhr-49 and sbp-1 mutant backgrounds revealed their essential roles in zearalenone-induced obesogenic effects. Exposure to 50 μM zearalenone significantly decreased mitochondrial content, potentially linked to upregulation of the mitochondrial fission gene drp-1. Oil Red O assays using drp-1 RNAi worms suggested that zearalenone's obesogenic effects depended on drp-1. Molecular docking analysis indicated possible spontaneous binding of zearalenone to DRP-1 and its homologues across species. This study offers mechanistic insights into the obesogenic effects of early-life zearalenone exposure, involving interconnected lipid metabolism (sbp-1 and nhr-49) and mitochondrial fission (drp-1), both of which are evolutionarily conserved. - Source: PubMed
Publication date: 2026/03/05
How Chun MingChan Ya-ChinWei Chia-Cheng - Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, ultimately progressing to heart failure and increased mortality. Its pathogenesis involves multifactorial mechanisms, and the key causative genes remain to be fully elucidated. - Source: PubMed
Publication date: 2026/02/17
Wei AoyunZhang HaozhiHe OudieZhang NaWang MinPang AimingCui YujieXi Pengjiao - Regulatory T cells (Tregs) exhibit compromised immunosuppressive functions in psoriasis, yet understanding of their dysregulated perturbations remains limited. - Source: PubMed
Publication date: 2026/01/12
Huang ZhihaoSui YuanLiu Shengxiu - Nudix hydrolase 19 (NUDT19) is a peroxisomal enzyme that hydrolyzes CoA species at the phosphodiester bond and has been linked to peroxisomal dysfunction in the context of diabetic kidney disease. Despite its predominant expression in mouse kidneys, the physiological role of NUDT19 remains poorly understood. To investigate its function under metabolic stress, we fed Nudt19 mice a high fat diet (HFD) for 15 weeks. Nudt19 deletion exacerbated HFD-induced albuminuria, suggesting a previously unrecognized role in kidney function. This phenotype was associated with altered lipid metabolism in the kidneys, including reduced levels of non-esterified fatty acids and specific mono-acyl lipids, as well as differential expression of proteins involved in lipid metabolism. These included ECH1, THIKB, and ECHD2, enzymes involved in peroxisomal and mitochondrial β-oxidation; C19orf12, a lipid droplet-associated protein; and the lipolysis-stimulated lipoprotein receptor (LSR). These findings support the conclusion that NUDT19 contributes to the regulation of renal lipid homeostasis and that its loss exacerbates kidney dysfunction under conditions of dietary lipid overload. - Source: PubMed
Publication date: 2026/01/20
Saporito Dominique CKing Rachel DVickers Schuyler DWyda Emily ABalaji SruthiKolandaivelu SaravananBillington NeilKing Judy ALeonardi Roberta