Ask about this productRelated genes to: GATM Blocking Peptide
- Gene:
- GATM NIH gene
- Name:
- glycine amidinotransferase
- Previous symbol:
- -
- Synonyms:
- AGAT
- Chromosome:
- 15q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-20
- Date modifiied:
- 2016-10-05
Related products to: GATM Blocking Peptide
Related articles to: GATM Blocking Peptide
- This study aimed to identify a key target gene in proximal tubule cells (PTCs) of sepsis-induced acute kidney injury (S-AKI) and elucidate the underlying mechanisms. - Source: PubMed
Publication date: 2026/05/09
Yang RuhaoHu NiandanChen HairuiLi WenqiangZheng Ting - In chronic kidney disease (CKD), there is evidence of loss of function and fibrosis in the progression of tubular epithelial cells; however, the cellular heterogeneity and underlying molecular mechanisms are not well defined. Knowledge of the diversity among tubular cells is essential for precision medicine therapy. - Source: PubMed
Publication date: 2026/04/17
Mao XinhuiWei MinggangLi YilinXia Ping - Chronic kidney disease (CKD) is increasing globally, presenting a critical health challenge. Renal fibrosis, the main pathological feature of CKD, is poorly understood and lacks targeted therapies. Here, we reveal that 5-methylcytosine (m5C) RNA methylation, primarily mediated by methyltransferase NSUN2, is significantly upregulated in renal fibrosis. Reduction of m5C RNA methylation levels upon NSUN2 loss attenuates fibrosis responses in cells, and specific knockout of NSUN2 in renal tubular epithelial cells alleviates renal fibrosis in several disease models. Mechanistically, NSUN2 methylates and stabilizes glycine amidinetransferase (GATM) mRNA. GATM exacerbates mitochondrial fission not only by directly binding to Drp1 but also through its product creatine, collectively driving the progression of renal fibrosis. We subsequently identify an inhibitor of NSUN2 that mitigates the progression of renal fibrosis. Collectively, our study demonstrates that targeting NSUN2-mediated m5C methylation of GATM mRNA therapeutically offers a promising strategy to slow the progression of CKD. - Source: PubMed
Publication date: 2026/04/16
Suo XiaoguoZhang MengmengZhu QiLuo QichaoWang FangGe QinglinPeng LijinYu JutaoWei JieHou ChaoJi MingluZhang DanfengWu LinhuiWang ZhijuanLi ChaoChen XinZhu SaiXie ShuaishuaiDong Yu-HangChen PengYang ChenJin JuanChen FeiXavierWang JiananMeng Xiaoming - Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified several candidate genes, a comprehensive understanding of the local and systemic regulatory networks is lacking. This study aims to dissect the complex molecular basis of high prolificacy in goats through an integrated multi-omics approach. - Source: PubMed
Publication date: 2026/04/06
Jiang FanTao HuChen MengjieShangguan AishaoLv HaimiaoHua ZaidongZhang NianZhang FengXu TianWang WenMa ChengtaoXiong Qi - Defining how proteins change over developmental time is amenable to studies deciphering regulatory genetic networks in vertebrate development, biology, and pharmacology. In an approach toward such quantitative studies of dynamic network behavior, we produced an atlas using the mass spectrometry-based method to investigate protein expression changes across 16 time points from the zygote to the early pharyngula stage zebrafish embryos. We systematically summarize 8 clusters for interrogating changes in protein expression associated with the development of zebrafish embryos. Specifically, we identified a class of zinc finger-related transcription factors primarily located on the long arm of chromosome 4, which are highly expressed during zygotic genome activation. Furthermore, we highlight the power of this analysis to assign developmental stage-specific expression information to chromosomes and tissues. Time-resolved analyses reveal significant discordance between differential transcript and protein expression, whereas no time lag is observed for proteins involved in stable and fundamental biological processes, such as metabolism (e.g., Ppt2a and Gatm), cytoskeletal organization (e.g., Col18a1), and the translation machinery (e.g., Eif4enif1). This atlas offers high-resolution and in-depth molecular insights into zebrafish development, providing a resource for developmental biologists to generate hypotheses for functional analysis of proteins during early vertebrate embryogenesis. - Source: PubMed
Publication date: 2026/03/26
Fang FeiPoulos WilliamYue YifanLi KunCibelli Jose BLiu XiaowenSun Liangliang