Ask about this productRelated genes to: PODXL Blocking Peptide
- Gene:
- PODXL NIH gene
- Name:
- podocalyxin like
- Previous symbol:
- -
- Synonyms:
- PCLP, Gp200, PC
- Chromosome:
- 7q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-11
- Date modifiied:
- 2016-10-05
Related products to: PODXL Blocking Peptide
Related articles to: PODXL Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/21
Celik NiluferCelik OnderUlug UlunErsahin AynurGurkan NaziyeGungor KaganYardim MeltemDalkilic SemihTektemur AhmetCelik SudenazGungor Nur DokuzeylulDuran Cevdet - To investigate whether ovarian endometrioma is associated with disruption of the endocrine-regulated transition between the anti-adhesive modulator podocalyxin (PCX) and the adhesive modulator leukemia inhibitory factor (LIF) in the endometrium. - Source: PubMed
Publication date: 2026/04/21
Karakelleoğlu GökçenurKaradağ Cihan - Neurochondrin (NCDN) has been recently identified as overexpressed in liver metastatic colorectal cancer (CRC) cells compared to poorly metastatic isogenic counterparts. While its cellular function and role in cancer and CRC remain unknown, patient survival data indicate that elevated NCDN levels are associated with poor prognosis. After validating these observations in an independent patient cohort, we sought to investigate the role of NCDN in CRC progression using isogenic CRC cell models comprising poorly metastatic KM12C and liver-metastatic KM12SM cells, and poorly metastatic SW480 and lymph node-metastatic SW620 cells. Stable silencing of NCDN expression in these cell lines resulted in a significant reduction in their tumorigenic and metastatic properties in vitro. Furthermore, in vivo assays using nude mice and the KM12 cell model demonstrated that NCDN is essential for tumor initiation, growth, and liver metastasis of CRC cells. Proteomic profiling of NCDN-silenced cells uncovered a set of dysregulated proteins associated with cell adhesion, invasion, cell death, and differentiation, and mitochondrial dysfunction, emerging NCDN-PODXL-EZR axis as a critical mediator of CRC progression and involved in liver metastasis. Our findings position NCDN and their associated dysregulated proteins as drivers of CRC progression and promising targets for further investigation. - Source: PubMed
Publication date: 2026/04/17
Garranzo-Asensio MaríaCarral-Ibarra ElisaMontero-Calle AnaGómez de Cedrón MartaVelázquez-Gutiérrez JavierMolina SusanaDziakova JanaSanz-López RodrigoPovès CarmenRamírez de Molina AnaMartínez-Useros JavierFernández-Aceñero María JesúsBartolomé Rubén ABarderas Rodrigo - Copper and levonorgestrel-releasing intrauterine devices (IUDs) primarily prevent pregnancy through pre-fertilization mechanisms; however, their potential effects on endometrial receptivity remain incompletely understood. This study aimed to compare the regulation of selected adhesive and anti-adhesive endometrial receptivity markers in women using copper and levonorgestrel-releasing IUDs. - Source: PubMed
Publication date: 2026/03/30
Karakelleoğlu Gökçenur - Podocyte injury is an early hallmark of chronic kidney disease (CKD) and can be influenced by SGLT2 inhibitors (SGLT2i). Early effects of SGLT2i include transient estimated glomerular filtration rate (eGFR) dip and reduced proteinuria; however, the latter may be subtle in patients with normal or moderately increased albuminuria. In such cases, urinary podocyte-derived biomarkers may provide sensitive early indicators of SGLT2i effect. This study prospectively assessed short-term changes in urinary podocyte biomarkers (nephrin, podocin, podocalyxin) following SGLT2i initiation in diabetic and non-diabetic CKD patients. Our cohort had a low urinary albumin to creatinine ratio (UACR) of 19.09 mg/g (6.28; 164.93) and preserved eGFR 45 mL/min/1.73 m (36.85; 53.15). At baseline, podocyte biomarkers were mutually correlated, whereas only podocalyxin was associated with UACR. Baseline podocalyxin independently predicted transient eGFR dip and UACR reduction. Early decreases in both podocin and podocalyxin were associated with eGFR decline and lower UACR at 3 months. ROC analyses identified cutoff values for all three biomarkers that predicted short-term eGFR decline, with baseline podocalyxin demonstrating the highest discriminative accuracy. These findings support pleiotropic nephroprotective effects of SGLT2 inhibitors and identify urinary podocyte biomarkers-particularly podocalyxin, and to a lesser extent podocin-as a sensitive indicator of early renal response. - Source: PubMed
Publication date: 2026/03/23
Urs AlexandraMoldovan DianaRusu Crina ClaudiaBondor Cosmina IoanaPotra Alina RamonaTirinescu DacianȚicală MariaMaslyennikov YuriyBărar Andrada AlinaDînșoreanu IoanaKacso Ina Maria